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3.4.21.46: complement factor D

This is an abbreviated version!
For detailed information about complement factor D, go to the full flat file.

Word Map on EC 3.4.21.46

Reaction

selective cleavage of Arg-/-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor =

Synonyms

28 kDa protein, adipocyte, Adipsin, alternative complement pathway component Factor D, C3 convertase activator, C3 proactivator convertase, CFD, complement factor D/adipsin and kallikrein-like serine protease, convertase, C3 proactivator, Df, Df protein, endogenous vascular elastase, esterase, properdin factor D, factor D, factor D (complement), fD, PDGF-D, platelet-derived growth factor D, PoDAK, vascular endothelial growth factor, vascular endothelial growth factor D, VEGF-D

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.46 complement factor D

Sequence

topprint

Sequence on EC 3.4.21.46 - complement factor D

Please use the AA Sequence and Transmembrane Helices Search for a specific query.
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CFAD_HUMAN
253
0
27033
Swiss-Prot
Secretory Pathway (Reliability: 2)
CFAD_MOUSE
259
0
28057
Swiss-Prot
Secretory Pathway (Reliability: 2)
CFAD_PIG
259
0
27764
Swiss-Prot
Secretory Pathway (Reliability: 1)
CFAD_RAT
263
0
28442
Swiss-Prot
Secretory Pathway (Reliability: 1)
CFAD_BOVIN
259
0
27878
Swiss-Prot
Secretory Pathway (Reliability: 2)
H0V7F3_CAVPO
216
0
23285
TrEMBL
other Location (Reliability: 3)
A0A3Q7PLZ0_CALUR
258
0
27517
TrEMBL
Secretory Pathway (Reliability: 2)
A0A3Q2LBP6_HORSE
419
0
43932
TrEMBL
other Location (Reliability: 2)
S9YFG2_CAMFR
373
0
38896
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2F0BF12_ESCRO
183
0
18962
TrEMBL
other Location (Reliability: 3)
A0A6J0AMK7_VICPA
258
0
27575
TrEMBL
Secretory Pathway (Reliability: 2)
G9K370_ICTPU
250
0
26899
TrEMBL
Secretory Pathway (Reliability: 1)
A0A480UQ82_PIG
259
0
27764
TrEMBL
Secretory Pathway (Reliability: 1)
Q6DBS8_DANRE
249
0
27261
TrEMBL
Secretory Pathway (Reliability: 2)
A0A671FH17_RHIFE
259
0
28037
TrEMBL
Secretory Pathway (Reliability: 2)
W5PJ66_SHEEP
259
0
27892
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8B7VJF4_CASCN
219
0
23647
TrEMBL
other Location (Reliability: 3)
A0A2Y9IF68_NEOSC
259
0
27633
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8C0S7R6_CANLF
420
0
44025
TrEMBL
Secretory Pathway (Reliability: 4)
A0A8I3NTV7_CANLF
257
0
27737
TrEMBL
Secretory Pathway (Reliability: 2)
Q9GMD8_ORNAN
159
0
17549
TrEMBL
other Location (Reliability: 1)
A0A8C4PUF6_EQUAS
437
0
45950
TrEMBL
other Location (Reliability: 4)
A0A7J8BPL4_ROUAE
260
0
27940
TrEMBL
Secretory Pathway (Reliability: 4)
Q6FHW3_HUMAN
228
0
24423
TrEMBL
other Location (Reliability: 3)
A0A8B9WTG6_BOSMU
302
0
32397
TrEMBL
other Location (Reliability: 3)
A0A8B8RVU2_CAMFR
258
0
27574
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8C2S3H8_CAPHI
265
0
28987
TrEMBL
Mitochondrion (Reliability: 4)
A0A341AZD3_NEOAA
216
0
22963
TrEMBL
Secretory Pathway (Reliability: 2)
G1L891_AILME
259
0
27539
TrEMBL
Secretory Pathway (Reliability: 3)
G1NZU9_MYOLU
268
0
28857
TrEMBL
other Location (Reliability: 5)
G3V7H3_RAT
263
0
28542
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I3W1B0_CALJA
268
0
29177
TrEMBL
other Location (Reliability: 4)
A0A8B6D772_MYTGA
312
0
34865
TrEMBL
other Location (Reliability: 2)
A0A5E4BHG7_MARMO
257
0
27323
TrEMBL
Secretory Pathway (Reliability: 2)
L8HP71_9CETA
256
0
27599
TrEMBL
Secretory Pathway (Reliability: 3)
A0A3Q7UAT0_VULVU
173
0
17962
TrEMBL
Secretory Pathway (Reliability: 3)
A0A8I3RY54_CANLF
335
0
35560
TrEMBL
Secretory Pathway (Reliability: 4)
D2HMC9_AILME
180
0
19617
TrEMBL
Mitochondrion (Reliability: 2)
A0A6P5QJL8_MUSCR
259
0
28149
TrEMBL
Secretory Pathway (Reliability: 1)
A0A7J7X9B1_PIPKU
274
0
29496
TrEMBL
Secretory Pathway (Reliability: 2)
A0A452F6V7_CAPHI
259
0
27911
TrEMBL
Secretory Pathway (Reliability: 2)
A0A6P3HWG7_BISBI
259
0
27878
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8C5VQT3_MICMU
258
0
27805
TrEMBL
Secretory Pathway (Reliability: 2)
A0A6J1YJQ3_ACIJB
219
0
23535
TrEMBL
other Location (Reliability: 2)
A0A8B6HT38_MYTGA
289
1
32520
TrEMBL
Secretory Pathway (Reliability: 1)
A0A5E4BGM6_MARMO
258
0
27410
TrEMBL
Secretory Pathway (Reliability: 2)
A0A7N5K1N5_AILME
75
0
8173
TrEMBL
Secretory Pathway (Reliability: 1)
A0A834DU45_9CHIR
274
0
29512
TrEMBL
Secretory Pathway (Reliability: 1)
A0A3Q7VFF5_URSAR
259
0
27509
TrEMBL
Secretory Pathway (Reliability: 3)
A0A6P3EVT2_OCTDE
254
0
26966
TrEMBL
Secretory Pathway (Reliability: 2)
F6W0D1_ORNAN
238
0
26143
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2K6QT24_RHIRO
216
1
22651
TrEMBL
Secretory Pathway (Reliability: 1)
F6YBP7_MACMU
260
1
28020
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6J3R7Y9_TURTR
259
0
27779
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8B9WSN4_BOSMU
306
0
32985
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2K5I6U5_COLAP
272
0
30356
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8C0NV83_CANLF
257
0
27737
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2Y9DPT5_TRIMA
256
0
27376
TrEMBL
Secretory Pathway (Reliability: 2)
A0A673TBK5_SURSU
341
0
35939
TrEMBL
other Location (Reliability: 4)
B4F449_PIG
130
0
14401
TrEMBL
other Location (Reliability: 1)
A0A2I2Z4B4_GORGO
279
0
29962
TrEMBL
Secretory Pathway (Reliability: 2)
A0A7N9D443_MACFA
203
0
21505
TrEMBL
other Location (Reliability: 4)
A0A2K6BTQ1_MACNE
253
0
27281
TrEMBL
Secretory Pathway (Reliability: 2)
S7MUM7_MYOBR
97
0
10340
TrEMBL
other Location (Reliability: 2)
A0A2Y9FWE7_PHYMC
260
0
27877
TrEMBL
Secretory Pathway (Reliability: 2)
A0A7J7XEB0_MYOMY
255
0
27267
TrEMBL
Secretory Pathway (Reliability: 2)
A0A7J7XEW7_MYOMY
273
0
29329
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8I3NIC8_CANLF
420
0
44025
TrEMBL
Secretory Pathway (Reliability: 4)
A0A8C9BRC2_PHOSS
261
0
28171
TrEMBL
Secretory Pathway (Reliability: 1)
A0A5J5N5L5_MUNRE
259
0
27908
TrEMBL
Secretory Pathway (Reliability: 2)
A0A452CCX1_BALAS
208
0
21974
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8C5K8N7_JACJA
258
0
27688
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8D2EVE8_THEGE
253
0
27262
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8C6AI81_MONMO
259
0
27731
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2K5DNE6_AOTNA
174
0
18408
TrEMBL
Secretory Pathway (Reliability: 2)
A0A3Q7N9X9_CALUR
259
0
27588
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8C9GR29_9PRIM
253
0
27257
TrEMBL
Secretory Pathway (Reliability: 2)
A0A0D9RJT4_CHLSB
253
0
27274
TrEMBL
Secretory Pathway (Reliability: 2)
A0A4W2H7U7_BOBOX
259
0
27878
TrEMBL
Secretory Pathway (Reliability: 2)
H2R6K0_PANTR
253
0
27052
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8C0C3Z4_BALMU
259
0
27676
TrEMBL
Secretory Pathway (Reliability: 2)
Q3UP47_MOUSE
259
0
28057
TrEMBL
Secretory Pathway (Reliability: 2)
A0A6J0X7Z0_ODOVR
259
0
27939
TrEMBL
Secretory Pathway (Reliability: 2)
A0A340XMJ5_LIPVE
197
0
20885
TrEMBL
Secretory Pathway (Reliability: 2)
A6XNE2_HUMAN
260
0
27780
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8C0S8I7_CANLF
340
0
36112
TrEMBL
Secretory Pathway (Reliability: 4)
A0A4X2KTW3_VOMUR
258
0
28123
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8D2HNV0_UROPR
405
0
43414
TrEMBL
other Location (Reliability: 2)
A0A7J8I596_MOLMO
183
0
19719
TrEMBL
other Location (Reliability: 3)
I3MZR5_ICTTR
258
0
27503
TrEMBL
Secretory Pathway (Reliability: 2)
A0A6J2CGJ8_ZALCA
258
0
27588
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8C0KZD4_CANLU
261
0
28007
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8C5ZE11_MARMA
303
0
31856
TrEMBL
Mitochondrion (Reliability: 2)
K9IZF4_DESRO
274
0
29320
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8D2HW26_UROPR
258
0
27439
TrEMBL
Secretory Pathway (Reliability: 2)
A0A3L7HHY0_CRIGR
220
0
24032
TrEMBL
other Location (Reliability: 2)
A0A2U3YAS2_LEPWE
259
0
27649
TrEMBL
Secretory Pathway (Reliability: 2)
A0A7N4V4J2_SARHA
258
0
27915
TrEMBL
Secretory Pathway (Reliability: 2)
A0A7J8BQ81_ROUAE
266
0
28731
TrEMBL
Secretory Pathway (Reliability: 2)
A0A667G2P1_LYNCA
427
0
44302
TrEMBL
Mitochondrion (Reliability: 5)
A0A452QMJ5_URSAM
259
0
27509
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2K6UMN1_SAIBB
208
0
21784
TrEMBL
Secretory Pathway (Reliability: 2)
A0A485MP16_LYNPA
219
0
23546
TrEMBL
other Location (Reliability: 2)
A0A6I9LJQ9_PERMB
259
0
27603
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2K5SFP4_CEBIM
208
0
21754
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8B7AYX4_ORYAF
259
0
27773
TrEMBL
Secretory Pathway (Reliability: 1)
A0A5N4CJY1_CAMDR
259
0
27645
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R9C0X9_PANPA
225
0
24364
TrEMBL
Secretory Pathway (Reliability: 4)
A0A8C6E6J4_MOSMO
259
0
27826
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2K6FV79_PROCO
258
0
27640
TrEMBL
Secretory Pathway (Reliability: 1)
M1EJM8_MUSPF
244
0
26380
TrEMBL
Mitochondrion (Reliability: 3)
K7ERG9_HUMAN
260
0
27863
TrEMBL
Secretory Pathway (Reliability: 1)
A0A7J8I4H1_MOLMO
229
0
24937
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8I3X920_CALJA
310
0
33883
TrEMBL
other Location (Reliability: 5)
H9EXC1_MACMU
253
0
27262
TrEMBL
Secretory Pathway (Reliability: 2)
A0A337SQJ3_FELCA
259
0
27691
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8C3VXE3_9CETA
253
0
27131
TrEMBL
Secretory Pathway (Reliability: 2)
A0A834QBT8_MARMO
258
0
27380
TrEMBL
Secretory Pathway (Reliability: 2)
Q6JVS2_PIG
83
0
9161
TrEMBL
other Location (Reliability: 2)
A0A8B8RX14_CAMFR
259
0
27645
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6P3TSE6_SHEEP
259
0
27892
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2K5LFV9_CERAT
253
0
27290
TrEMBL
Secretory Pathway (Reliability: 2)
A0A6J2CEH0_ZALCA
259
0
27659
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8B9WTW2_BOSMU
322
0
34556
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2Y9MGR1_DELLE
259
0
27732
TrEMBL
Secretory Pathway (Reliability: 2)
A0A3P4MAK7_GULGU
110
0
11666
TrEMBL
Mitochondrion (Reliability: 5)
A0A6B0RPW7_9CETA
262
0
28185
TrEMBL
Secretory Pathway (Reliability: 4)
A0A8B7SJG3_HIPAR
259
0
27728
TrEMBL
Secretory Pathway (Reliability: 2)
T1W3L7_PANTA
64
0
6571
TrEMBL
other Location (Reliability: 2)
A0A061I2Z8_CRIGR
259
0
28037
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8B6HSB2_MYTGA
275
0
30796
TrEMBL
other Location (Reliability: 2)
A0A8C6G8S6_MUSSI
258
0
28013
TrEMBL
Secretory Pathway (Reliability: 2)
A0A7N5P8R7_AILME
337
0
35841
TrEMBL
Secretory Pathway (Reliability: 3)
A0A1Z5KKB9_FISSO
362
0
40417
TrEMBL
other Location (Reliability: 2)
A0A6P5J2E8_PHACI
258
0
27987
TrEMBL
Secretory Pathway (Reliability: 3)
G5C5X5_HETGA
241
0
25388
TrEMBL
Secretory Pathway (Reliability: 3)
A0A6J3FSH1_SAPAP
253
0
26950
TrEMBL
Secretory Pathway (Reliability: 2)
A0A6P5QCT9_MUSCR
258
0
28078
TrEMBL
Secretory Pathway (Reliability: 1)
B7ZNS9_MOUSE
258
0
27986
TrEMBL
Secretory Pathway (Reliability: 2)
H0XZ59_OTOGA
259
0
27569
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8D2DY96_SCIVU
263
0
28097
TrEMBL
Secretory Pathway (Reliability: 1)
H2NWR7_PONAB
260
0
27976
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2J8RA50_PONAB
253
0
27146
TrEMBL
Secretory Pathway (Reliability: 2)
M3W7H5_FELCA
353
0
36647
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8B9WV13_BOSMU
259
0
27894
TrEMBL
Secretory Pathway (Reliability: 2)
A0A5N3WN38_MUNMU
259
0
27908
TrEMBL
Secretory Pathway (Reliability: 2)
A0A811ZB11_NYCPR
264
0
28397
TrEMBL
Secretory Pathway (Reliability: 3)
A0A6I9I8X8_VICPA
259
0
27646
TrEMBL
Secretory Pathway (Reliability: 2)
A0A250YDR4_CASCN
258
0
27779
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8C9AN09_PROSS
263
0
28382
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8B9WUY6_BOSMU
330
0
34784
TrEMBL
other Location (Reliability: 2)
G3QES0_GORGO
258
0
27615
TrEMBL
Secretory Pathway (Reliability: 2)
A0A485MKH9_LYNPA
259
0
27730
TrEMBL
Secretory Pathway (Reliability: 1)
A0A6I8N914_ORNAN
258
0
28370
TrEMBL
Secretory Pathway (Reliability: 1)
U3C211_CALJA
253
0
27242
TrEMBL
Secretory Pathway (Reliability: 2)
A0A7J8I5U3_MOLMO
259
0
27872
TrEMBL
Secretory Pathway (Reliability: 1)
G3HF50_CRIGR
235
0
25665
TrEMBL
other Location (Reliability: 3)
A0A2Y9LC89_ENHLU
259
0
27937
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2J8RA42_PONAB
260
0
27976
TrEMBL
Secretory Pathway (Reliability: 1)
L5LTR7_MYODS
203
0
21190
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2R9CB19_PANPA
243
0
26070
TrEMBL
Secretory Pathway (Reliability: 1)
A0A8C6QG65_NANGA
258
0
27648
TrEMBL
Secretory Pathway (Reliability: 1)
G1QJT7_NOMLE
207
0
22159
TrEMBL
Secretory Pathway (Reliability: 1)
A0A667GJ46_LYNCA
259
0
27747
TrEMBL
Secretory Pathway (Reliability: 1)
L5L6L9_PTEAL
260
0
27899
TrEMBL
Secretory Pathway (Reliability: 5)
A0A6P4UYI7_PANPR
245
0
26199
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2U3VKQ2_ODORO
259
0
27590
TrEMBL
Secretory Pathway (Reliability: 2)
C9D6Z6_PAROL
277
0
30008
TrEMBL
-
VEGFD_HUMAN
354
0
40444
Swiss-Prot
-