3.4.21.45: complement factor I
This is an abbreviated version!
For detailed information about complement factor I, go to the full flat file.
Word Map on EC 3.4.21.45
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3.4.21.45
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hemolytic
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convertase
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macular
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properdin
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uremic
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cell-bound
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c3d
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fluid-phase
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glomerulonephritis
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complement-mediated
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opsonization
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medicine
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i-mediated
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eculizumab
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alpha\'-chain
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c4-binding
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c4bp
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microangiopathic
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opsonin
- 3.4.21.45
-
hemolytic
-
convertase
-
macular
- properdin
-
uremic
-
cell-bound
- c3d
-
fluid-phase
- glomerulonephritis
-
complement-mediated
-
opsonization
- medicine
-
i-mediated
- eculizumab
-
alpha\'-chain
-
c4-binding
- c4bp
-
microangiopathic
-
opsonin
Reaction
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage =
Synonyms
C3b inactivator, C3b/C4b inactivator, C3bINA, CFI, complement C3b inactivator, complement C3b/C4b inactivator, complement C4b inactivator, complement C4bi, complement compoment C3b inactivator, complement factor I, complement inhibitor factor I, complement regulator factor I, conglutinogen-activating factor C, factor I, factor I-like activity, fI, GcIf-1, GcIf-2, GcIf-3, GcIf-4, IF, plasma protease factor I, serine protease Factor I
ECTree
3.4.21.45 complement factor IAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.21.45 - complement factor I
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
no mRNA of complement factor I detected in carcinoid cells H720, H727
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RPE-Bruch's membrane-choriocapillaris complex from eyes of 12-month-old neprilysin gene-disrupted mice and age-matched wild-type mice
transfected with mutant and wild-type forms of complement factor I
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only isolated hepatocytes but neither Kupffer cells, hepatic stellate cells or sinusoidal endothelial cells express FI-specific mRNA
incubation of foreskin with thermolysin followed by trypsinization
LCC, no mRNA expression detected in LCC H661
AC, mRNA of complement factor I detected in H2087 and H358 but not in H1264 and A549
SCC, squamous cell carcinoma, mRNA of complement factor I detected in H226 but not in H157, H1385
SCLC, no mRNA of complement factor I detected in H69, H82, H187, H209, H345, N417, H510
additional information
additional information
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the enzyme is produced mainly in the liver but also by monocytes, fibroblasts, keratinocytes, and endothelial cells
additional information
complement factor I is expressed in various tissues
additional information
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complement factor I is expressed in various tissues
additional information
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Nipah virus-associated factor I-like activity that cleaves C3b can be derived from the infected HeLa cells
additional information
no expression detected in heart, kidney and spleen
additional information
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no expression detected in heart, kidney and spleen
