3.4.21.45: complement factor I

This is an abbreviated version!
For detailed information about complement factor I, go to the full flat file.

Word Map on EC 3.4.21.45

3.4.21.45

hemolytic

convertase

macular

properdin

uremic

cell-bound

c3d

fluid-phase

glomerulonephritis

complement-mediated

opsonization

medicine

i-mediated

eculizumab

alpha\'-chain

c4-binding

c4bp

microangiopathic

opsonin

Reaction

Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage =

Synonyms

C3b inactivator, C3b/C4b inactivator, C3bINA, CFI, complement C3b inactivator, complement C3b/C4b inactivator, complement C4b inactivator, complement C4bi, complement compoment C3b inactivator, complement factor I, complement inhibitor factor I, complement regulator factor I, conglutinogen-activating factor C, factor I, factor I-like activity, fI, GcIf-1, GcIf-2, GcIf-3, GcIf-4, IF, plasma protease factor I, serine protease Factor I

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.45 complement factor I

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Results	in table
24	Activating Compound
30	AA Sequence
17	Application
1	CAS Registry Number
16	Cloned(Commentary)
13	Cofactor
1	Crystallization (Commentary)
357	Disease/ Diagnostics
1	Expression
10	General Information
1	General Stability
39	Inhibitors
20	KM Value [mM]
7	Localization
2	Metals/Ions
61	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
56	Organism
8	PDB ID
5	pH Optimum
1	pH Range
1	pH Stability
1	pI Value
12	Posttranslational Modification
79	Protein Variants
20	Purification (Commentary)
1	Reaction
1	Reaction Type
53	Reference
1	Renatured (Commentary)
74	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
95	Substrates and Products (Substrate)
13	Subunits
53	Synonyms
12	Temperature Optimum [°C]
1	Temperature Stability [°C]

Localization

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Localization on EC 3.4.21.45 - complement factor I

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endoplasmic reticulum

Homo sapiens

upon EndoH digestion, a large fraction of wild-type complement factor I is EndoH sensitive and displays faster mobility upon electrophoresis representing protein in endoplasmic reticulum still undergoing processing, but significant amount of wild-type complement factor I is resistant to EndoH indicates transport to late secretory compartments and beyond