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3.4.21.45: complement factor I

This is an abbreviated version!
For detailed information about complement factor I, go to the full flat file.

Word Map on EC 3.4.21.45

Reaction

Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage =

Synonyms

C3b inactivator, C3b/C4b inactivator, C3bINA, CFI, complement C3b inactivator, complement C3b/C4b inactivator, complement C4b inactivator, complement C4bi, complement compoment C3b inactivator, complement factor I, complement inhibitor factor I, complement regulator factor I, conglutinogen-activating factor C, factor I, factor I-like activity, fI, GcIf-1, GcIf-2, GcIf-3, GcIf-4, IF, plasma protease factor I, serine protease Factor I

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.45 complement factor I

Inhibitors

Inhibitors on EC 3.4.21.45 - complement factor I

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
10 mM, strong
4-(2-aminoethyl)benzenesulfonyl fluoride
-
0.25 mM, inhibits SP domain form and fI
amyloid beta
-
antipain
Aprotinin
benzamidine
-
20 mM, 82% inhibition of amidolytic activity
benzenesulfonyl fluorides
-
inhibits amidolytic activity
benzyloxycarbonyl-D-Phe-Pro-methoxypropylboroglycinepinanediol ester
-
0.05 mM, 82% inhibition; inhibits amidolytic activity
Cr2+
-
inhibition of proteolytic and amidolytic activity, 54% inhibition of amidolytic activity at 1 mM, 43% inhibition of proteolytic activity at 0.1 mM
Cu2+
-
23% inhibition of amidolytic activity at 1 mM
diisopropylfluorophosphate
-
-
dithiothreitol
-
1 mM, strong
epsilon-aminocaproic acid
-
20 mM, 10% inhibition of amidolytic activity
factor H
-
inhibits SP domain form
-
Fe3+
-
inhibition of proteolytic and amidolytic activity, 59% inhibition of amidolytic activity at 1 mM, 23% inhibition of proteolytic activity at 0.1 mM
Hg2+
-
26% inhibition of amidolytic activity at 1 mM
Hirudin
-
-
-
K-76COOH
leupeptin
Lima bean trypsin inhibitor
-
0.05 mM, 20% inhibition of amidolytic activity
-
NEM
-
1 mM, partial inhibition
Pefabloc TH
-
0.25 mM, 58% inhibition of amidolytic activity
Pefabloc-SC
-
0.00025 mM, complete inhibition of amidolytic activity
Pefabloc-Xa
-
0.00025 mM, 93% inhibition of amidolytic activity
PMSF
-
1 mM, 42% inhibition of amidolytic activity
Soybean trypsin inhibitor
-
0.05 mM, 37% inhibition of amidolytic activity
-
suramin
Zn2+
-
0.1 mM, 59% inhibition of proteolytic activity
additional information
-