3.4.21.43: classical-complement-pathway C3/C5 convertase

This is an abbreviated version, for detailed information about classical-complement-pathway C3/C5 convertase, go to the full flat file.

Reaction

Selective cleavage of Arg-/-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-/- bond in complement component C5 alpha-chain to form C5a and C5b =

Synonyms

C3 convertase, C3/C5 convertase, C3b 2 Bb, C3b2Bb, C3bBb, C3bBbP, C4, C423, C4b,2a, C4b,2a,3b, C4b,C2a, C4b2a, C4b2a3b, C4b2aC3b, C4bC2a, C5 convertase, classical C3 convertase, classical C5 convertase, classical pathway C3 convertase, classical pathway C3/C5 convertase, classical pathway C5 convertase, complement C3 convertase, CP C5 convertase, EAC1,C4b,C2a, high affinity C5 convertase, soluble C3 convertase, surface-bound C3 convertase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.43 classical-complement-pathway C3/C5 convertase