3.4.21.42: complement subcomponent C1s

This is an abbreviated version!
For detailed information about complement subcomponent C1s, go to the full flat file.

Word Map on EC 3.4.21.42

3.4.21.42

angioedema

hereditary

lectin

c1-inh

edema

swell

mannose-binding

masp-1

mannan-binding

coagulation

kallikrein

airway

prophylaxis

abdominal

bradykinin

life-threatening

laryngeal

angioneurotic

lectin-associated

c1-inhibitor

danazol

prophylactic

ficolins

plasma-derived

urticaria

icatibant

antithrombin

submucosal

kinin

fibrinolysis

larynx

kallikrein-kinin

asphyxiation

antifibrinolytic

prekallikrein

2-antiplasmin

ecallantide

2-macroglobulin

tranexamic

kininogens

antihistamine

pharmacology

bradykinin-mediated

serping1

collectins

behring

c4d

medicine

collagen-like

drug development

tracheotomy

fibrinogen-like

stanozolol

Reaction

Cleavage of Arg-/-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-/-Lys bond in complement component C2 to form C2a and C2b: the "classical" pathway C3 convertase =

Synonyms

activated complement C1s, C1 esterase, C1-esterase, C1g, C1s, C1s protease, C1s serine protease, complement 1s, complement C.hivin. 1s, complement C1s, complement C1s, activated, complement component 1 s, complement component 1 subcomponent s, complement component C1s, complement protease, complement protease C1s, complement subcomponent 1s, complement subcomponent C1sbar, esterase, C1, mannan-binding lectin-associated serine protease-2, MASP-2, MBL-associated serine protease-2, multiprotein complex C1, protease C1s, serine protease C1s

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.42 complement subcomponent C1s

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Results	in table
3	Activating Compound
12	AA Sequence
9	Application
1	CAS Registry Number
15	Cloned(Commentary)
6	Crystallization (Commentary)
2775	Disease/ Diagnostics
2	Expression
14	General Information
2	General Stability
8	IC50 Value
80	Inhibitors
9	kcat/KM [mM/s]
35	Ki Value [mM]
35	KM Value [mM]
4	Localization
4	Metals/Ions
17	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
61	Organism
18	PDB ID
9	pH Optimum
1	pH Range
2	pH Stability
2	pI Value
16	Posttranslational Modification
27	Protein Variants
16	Purification (Commentary)
1	Reaction
60	Reference
45	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
166	Substrates and Products (Substrate)
14	Subunits
65	Synonyms
6	Temperature Optimum [°C]
2	Temperature Stability [°C]
67	Turnover Number [1/s]

Subunits

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Subunits on EC 3.4.21.42 - complement subcomponent C1s

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6 entries

dimer

Homo sapiens

P09871

recombinant CUB1-EGF-CUB2 region of enzyme C1s, monomers associate to form an X-shaped dimer through lateral association of the CUB1 and EGF-like domains about the crystallographic symmetry axis. The interface features a number of hydrophobic side chains

732820

heteropentamer

Homo sapiens

C1q, 2 * C1s, 2 * C1r

717805

homodimer

2 entries

monomer

Homo sapiens

1 * 88000 ,immunoblotting, both joint fluid and purified material, 1 * 90000, SDS-PAGE and 1 * 86000, SDS-PAGE

700551

tetramer

Homo sapiens

P09871

in the absence of collagen peptide, C1s crystallizes to form a tetramer, similar to the native C1r-C1s-C1r-C1s complex. The tetramer is a flat ring with an outer diameter of about 120 A

732820

additional information

2 entries