Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.21.42: complement subcomponent C1s

This is an abbreviated version!
For detailed information about complement subcomponent C1s, go to the full flat file.

Word Map on EC 3.4.21.42

Reaction

Cleavage of Arg-/-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-/-Lys bond in complement component C2 to form C2a and C2b: the "classical" pathway C3 convertase =

Synonyms

activated complement C1s, C1 esterase, C1-esterase, C1g, C1s, C1s protease, C1s serine protease, complement 1s, complement C.hivin. 1s, complement C1s, complement C1s, activated, complement component 1 s, complement component 1 subcomponent s, complement component C1s, complement protease, complement protease C1s, complement subcomponent 1s, complement subcomponent C1sbar, esterase, C1, mannan-binding lectin-associated serine protease-2, MASP-2, MBL-associated serine protease-2, multiprotein complex C1, protease C1s, serine protease C1s

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.42 complement subcomponent C1s

Application

Application on EC 3.4.21.42 - complement subcomponent C1s

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
-
further probing for cooperativity may be of great value in the development of a peptide inhibitor for the C1s protease in the treatment of inflammatory disease
medicine
pharmacology
inhibition of the complement pathway is of great therapeutic interest. The C1 complex is a very attractive target for selective inhibition of the classical complement pathway because it is the only member of the classical pathway that does not participate in the other complement pathways