3.4.21.39: chymase

This is an abbreviated version!
For detailed information about chymase, go to the full flat file.

Word Map on EC 3.4.21.39

3.4.21.39

tryptase

granule

degranulation

histamine

allergic

chemokines

ige

cathepsin

cardiac

artery

fibrosis

neutrophil

angiotensin-converting

eosinophil

cardiovascular

monocyte

asthma

heparin

airway

renin-angiotensin

rantes

chemoattractant

carboxypeptidase

c-kit

eotaxin

renin

elastase

chemotactic

basophil

angiotensinogen

endothelins

anaphylaxis

anaphylactic

toluidine

granzyme

mastocytosis

tryptase-positive

atopic

exocytosed

fcepsilonri

cromolyn

anti-ige

nippostrongylus

mip-1alpha

cell-deficient

mip-1beta

medicine

3clpro

enzyme-histochemical

non-ace

ige-mediated

Reaction

preferential cleavage: Phe-/- > Tyr-/- > Trp-/- > Leu-/- =

Synonyms

alpha-chymase, beta-chymase, CAGE, Chy, chymase, chymase 1, chymostatin sensitive angiotensin generating enzyme, chymotrypsin-like protease, chymotryptic mast cell peptidase, CLP, CMA, CMA1, HAM1, mast cell chymase, mast cell chymases 4, mast cell protease, mast cell protease 1, mast cell protease 4, mast cell protease I, mast cell protease-2, mast cell protease-4, mast cell specific chymase, mast cell-derived chymase, mast-cell-derived chymase, MC chymase, MC protease 4, MC-chymase, MC-derived chymase, MC-specific chymase, MCC, MCP-1, MCP-2, MCP-4, MCP-5, MCP-8, MCP2, MCP4, Mcpt, MCPT-4, MCPT4, MMCP-1, mucosal mast cell protease, mucosal mast cell protease-1, proteinase, mast cell serine, chymase, RMCP I, skeletal muscle protease, skin chymotryptic proteinase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.39 chymase

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Results	in table
8	Activating Compound
15	AA Sequence
14	Application
1	CAS Registry Number
18	Cloned(Commentary)
4	Crystallization (Commentary)
2692	Disease/ Diagnostics
11	Expression
26	General Information
1	General Stability
127	IC50 Value
396	Inhibitors
16	kcat/KM [mM/s]
98	Ki Value [mM]
107	KM Value [mM]
13	Localization
32	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
149	Organism
22	PDB ID
8	pH Optimum
2	pH Range
3	pH Stability
11	Posttranslational Modification
10	Protein Variants
30	Purification (Commentary)
1	Reaction
1	Reaction Type
148	Reference
150	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
342	Substrates and Products (Substrate)
23	Subunits
133	Synonyms
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
107	Turnover Number [1/s]

Purification

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Purification on EC 3.4.21.39 - chymase

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3 entries

aprotinin-Sepharose affinity column chromatography

Homo sapiens

698854

heparin Hyper M column chromatography and heparin affinity chromatography

Homo sapiens

732860

heparin-Sepharose column chromatography

Mesocricetus auratus

755179

heparin-Sepharose column chromatography and phenyl HP column chromatography

Ovis aries

P79204

753380

immobilized metal ion affinity chromatography (Ni2+), activation by His6-tag removal by cleavage with enterokinase, heparin-Sepharose chromatography

2 entries

Ni-NAT agarose bead chromatography, heparin affinity chromatography, and gel filtration

Mus musculus

681972

Ni-NTA agarose bead chromatography

Homo sapiens

P23946

732148

Ni-NTA agarose bead chromatography and heparin-agarose column chromatography

Monodelphis domestica

681970

Ni-NTA agarose bead chromatography and heparin-Sepharose column chromatograohy

2 entries

Ni-NTA agarose bead chromatography and heparin-Sepharose column chromatography

Mus musculus

680107

Ni-NTA agarose beads chromatography

Homo sapiens

P23946

732730

Ni-NTA column chromatography and Superdex 75 gel filtration

Cavia porcellus

A7WPL7

680901

recombinant enzyme, procedure for expression and purification from culture media

Homo sapiens

668033

reversed-phase high-performance liquid chromatography

Rattus norvegicus

681903