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angiotensin I + H2O
angiotensin II + ?
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
Big endothelin-1 + H2O
?
-
-
-
-
?
big-endothelin-1 (1-38) + H2O
endothelin-1 (1-31) + ?
Big-endothelin-1 + H2O
endothelin-1 (1-31) + ?
-
-
-
?
complement component C3 + H2O
?
-
-
-
-
?
complement component C3a + H2O
?
-
-
-
-
?
endothelin-1 + H2O
31 amino-acid fragment of ET-1 + ?
-
-
-
-
?
fibrinogen + H2O
fibrin + ?
-
chymase degrades the alpha-, beta- and gamma-chains of fibrinogen, while heparin enhances the degradation of the beta-chain
-
-
?
heat shock protein 70 + H2O
?
interleukin-18 + H2O
?
-
-
-
-
?
interleukin-1beta + H2O
?
-
-
-
-
?
pro-collagen + H2O
collagen + ?
-
-
-
?
pro-interleukin-1beta + H2O
interleukin-1beta + ?
-
-
-
?
pro-matrix metalloprotease 2 + H2O
matrix metalloprotease 2 + propeptide
-
-
-
-
?
pro-matrix metalloprotease 9 + H2O
matrix metalloprotease 9 + propeptide
-
-
-
-
?
pro-matrix metalloproteinase-1 + H2O
matrix metalloproteinase-1 + ?
-
-
-
?
pro-matrix metalloproteinase-3 + H2O
matrix metalloproteinase-3 + ?
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
pro-transforming growth factor-beta + H2O
transforming growth factor-beta + ?
-
-
-
?
pro-transforming growth factor-beta1 + H2O
transforming growth factor-beta1 + ?
-
-
-
?
procollagen + H2O
collagen + ?
promatrix metalloproteinase-2 + H2O
matrix metalloproteinase-2
promatrix metalloproteinase-9 + H2O
matrix metalloproteinase-9
tissue inhibitor of metalloproteinase-1 + H2O
?
tissue necrosis factor + H2O
?
-
-
-
?
transforming growth factor beta-binding protein + H2O
transforming growth factor beta + protein
-
-
-
-
?
transforming growth factor-beta1 + H2O
?
Vitronectin + H2O
?
-
-
-
?
additional information
?
-
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
selective hydrolysis at Phe8 to generate bioactive angiotensin II, which can promote cardiac hypertrophy, vascular stenosis, and hypertension
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
-
-
-
-
?
big-endothelin-1 (1-38) + H2O
endothelin-1 (1-31) + ?
-
chymase cleaves the tyrosine31-glycine32 peptide bond of big-endothelin-1 (1-38)
-
-
?
big-endothelin-1 (1-38) + H2O
endothelin-1 (1-31) + ?
-
chymase cleaves the tyrosine31-glycine32 peptide bond of big-endothelin-1 (1-38)
-
-
?
big-endothelin-1 + H2O
?
-
-
-
-
?
big-endothelin-1 + H2O
?
-
-
-
-
?
big-endothelin-2 + H2O
?
-
-
-
-
?
big-endothelin-2 + H2O
?
-
-
-
-
?
biglycan + H2O
?
-
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
Fibronectin + H2O
?
-
-
-
-
?
Fibronectin + H2O
?
-
-
-
?
heat shock protein 70 + H2O
?
-
-
-
?
heat shock protein 70 + H2O
?
-
-
-
?
HMGB1 + H2O
?
-
-
-
?
interleukin-33 + H2O
?
-
-
-
?
interleukin-33 + H2O
?
-
-
-
?
interleukin-33 + H2O
?
-
-
-
-
?
plasmin + H2O
?
-
-
-
-
?
plasmin + H2O
?
-
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
-
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
-
-
-
-
?
procollagen + H2O
collagen + ?
-
-
-
-
?
procollagen + H2O
collagen + ?
-
-
-
-
?
procollagen + H2O
collagen + ?
-
-
-
-
?
promatrix metalloproteinase-2 + H2O
matrix metalloproteinase-2
-
-
-
-
?
promatrix metalloproteinase-2 + H2O
matrix metalloproteinase-2
-
-
-
-
?
promatrix metalloproteinase-9 + H2O
matrix metalloproteinase-9
-
-
-
-
?
promatrix metalloproteinase-9 + H2O
matrix metalloproteinase-9
-
-
-
-
?
thrombin + H2O
?
-
-
-
-
?
thrombin + H2O
?
-
-
-
-
?
tissue inhibitor of metalloproteinase-1 + H2O
?
-
-
-
-
?
tissue inhibitor of metalloproteinase-1 + H2O
?
-
-
-
-
?
transforming growth factor-beta1 + H2O
?
-
-
-
-
?
transforming growth factor-beta1 + H2O
?
-
-
-
-
?
additional information
?
-
-
chymase mediates a major alternative way of angiotensin II production from angiotensin I beside angiotensin converting enzyme in the final step of the renin-angiotensin system. This enzyme is also involved in other physio-pathological processes such as angiogenesis, atherosclerosis and inflammation
-
-
?
additional information
?
-
-
chymase can activate eosinophils to markedly induce the release of chemokines CCL2 (monocyte chemotactic protein-1), CXCL1 (growth-regulated oncogene-alpha), CXCL8 (IL-8), and inflammatory cytokine IL-6, chymase activates ERK, p38 mitogen-activated protein kinase, Janus-activated kinase, Akt and nuclear factor-kappaB in eosinophils by induction of phosphorylation
-
-
?
additional information
?
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-
chymase only accepts aromatic amino acids in position P1, with a strong preference for Tyr and Phe over Trp. Aliphatic amino acids are preferred in positions P2 to P4 N-terminal of the cleaved bond. In the P1' position C-terminal of the cleaved bond, Ser is clearly over-represented and acidic amino acids Asp and Glu are strongly preferred in the P2' position. In P3', the small aliphatic amino acids Ala, Val and Gly are frequently observed.
-
-
?
additional information
?
-
interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation
-
-
?
additional information
?
-
-
interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation
-
-
?
additional information
?
-
interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation
-
-
?
additional information
?
-
-
interleukin-7, interleukin-22, GM-CSF, and CCL2 are resistant to chymase degradation
-
-
?
additional information
?
-
-
the enzyme plays a crucial or significant role in the process of degranulation
-
-
?
additional information
?
-
-
the enzyme plays a role in production of a chemotactic factor for neutrophil leukocytes after degranulation
-
-
?
additional information
?
-
-
proteolytic degradation of low density lipoproteins by mast cell granules results from coordinated action of the two granule-bound enzymes - chymase and carboxypeptidase A. The chymase first cleaves peptides from the apolipoprotein B of low density lipoproteins, and thereafter the carboxypeptidase A cleaves amino acids from the peptides formed
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?