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3.4.21.39: chymase

This is an abbreviated version!
For detailed information about chymase, go to the full flat file.

Word Map on EC 3.4.21.39

Reaction

preferential cleavage: Phe-/- > Tyr-/- > Trp-/- > Leu-/- =

Synonyms

alpha-chymase, beta-chymase, CAGE, Chy, chymase, chymase 1, chymostatin sensitive angiotensin generating enzyme, chymotrypsin-like protease, chymotryptic mast cell peptidase, CLP, CMA, CMA1, HAM1, mast cell chymase, mast cell chymases 4, mast cell protease, mast cell protease 1, mast cell protease 4, mast cell protease I, mast cell protease-2, mast cell protease-4, mast cell specific chymase, mast cell-derived chymase, mast-cell-derived chymase, MC chymase, MC protease 4, MC-chymase, MC-derived chymase, MC-specific chymase, MCC, MCP-1, MCP-2, MCP-4, MCP-5, MCP-8, MCP2, MCP4, Mcpt, MCPT-4, MCPT4, MMCP-1, mucosal mast cell protease, mucosal mast cell protease-1, proteinase, mast cell serine, chymase, RMCP I, skeletal muscle protease, skin chymotryptic proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.39 chymase

Natural Substrates Products

Natural Substrates Products on EC 3.4.21.39 - chymase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
angiotensin I + H2O
angiotensin II + ?
show the reaction diagram
-
-
-
-
?
angiotensin I + H2O
angiotensin II + His-Leu
show the reaction diagram
Big endothelin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
big-endothelin-1 (1-38) + H2O
endothelin-1 (1-31) + ?
show the reaction diagram
big-endothelin-1 + H2O
?
show the reaction diagram
Big-endothelin-1 + H2O
endothelin-1 (1-31) + ?
show the reaction diagram
-
-
-
?
big-endothelin-2 + H2O
?
show the reaction diagram
biglycan + H2O
?
show the reaction diagram
complement component C3 + H2O
?
show the reaction diagram
-
-
-
-
?
complement component C3a + H2O
?
show the reaction diagram
-
-
-
-
?
endothelin-1 + H2O
31 amino-acid fragment of ET-1 + ?
show the reaction diagram
-
-
-
-
?
Fibrin + H2O
?
show the reaction diagram
-
-
-
-
?
fibrinogen + H2O
fibrin + ?
show the reaction diagram
-
chymase degrades the alpha-, beta- and gamma-chains of fibrinogen, while heparin enhances the degradation of the beta-chain
-
-
?
Fibronectin + H2O
?
show the reaction diagram
heat shock protein 70 + H2O
?
show the reaction diagram
HMGB1 + H2O
?
show the reaction diagram
interleukin-18 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-1beta + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-33 + H2O
?
show the reaction diagram
plasmin + H2O
?
show the reaction diagram
pro-collagen + H2O
collagen + ?
show the reaction diagram
-
-
-
?
pro-interleukin-1beta + H2O
interleukin-1beta + ?
show the reaction diagram
-
-
-
?
pro-matrix metalloprotease 2 + H2O
matrix metalloprotease 2 + propeptide
show the reaction diagram
-
-
-
-
?
pro-matrix metalloprotease 9 + H2O
matrix metalloprotease 9 + propeptide
show the reaction diagram
-
-
-
-
?
pro-matrix metalloproteinase-1 + H2O
matrix metalloproteinase-1 + ?
show the reaction diagram
-
-
-
?
pro-matrix metalloproteinase-3 + H2O
matrix metalloproteinase-3 + ?
show the reaction diagram
-
-
-
?
pro-matrix metalloproteinase-9 + H2O
matrix metalloproteinase-9 + ?
show the reaction diagram
pro-transforming growth factor-beta + H2O
transforming growth factor-beta + ?
show the reaction diagram
-
-
-
?
pro-transforming growth factor-beta1 + H2O
transforming growth factor-beta1 + ?
show the reaction diagram
-
-
-
?
procollagen + H2O
collagen + ?
show the reaction diagram
promatrix metalloproteinase-2 + H2O
matrix metalloproteinase-2
show the reaction diagram
promatrix metalloproteinase-9 + H2O
matrix metalloproteinase-9
show the reaction diagram
thrombin + H2O
?
show the reaction diagram
tissue inhibitor of metalloproteinase-1 + H2O
?
show the reaction diagram
tissue necrosis factor + H2O
?
show the reaction diagram
-
-
-
?
transforming growth factor beta-binding protein + H2O
transforming growth factor beta + protein
show the reaction diagram
-
-
-
-
?
transforming growth factor-beta1 + H2O
?
show the reaction diagram
Vitronectin + H2O
?
show the reaction diagram
-
-
-
?
additional information
?
-