3.4.21.39: chymase

This is an abbreviated version!
For detailed information about chymase, go to the full flat file.

Word Map on EC 3.4.21.39

3.4.21.39

tryptase

granule

degranulation

histamine

allergic

chemokines

ige

cathepsin

cardiac

artery

fibrosis

neutrophil

angiotensin-converting

eosinophil

cardiovascular

monocyte

asthma

heparin

airway

renin-angiotensin

rantes

chemoattractant

carboxypeptidase

c-kit

eotaxin

renin

elastase

chemotactic

basophil

angiotensinogen

endothelins

anaphylaxis

anaphylactic

toluidine

granzyme

mastocytosis

tryptase-positive

atopic

exocytosed

fcepsilonri

cromolyn

anti-ige

nippostrongylus

mip-1alpha

cell-deficient

mip-1beta

medicine

3clpro

enzyme-histochemical

non-ace

ige-mediated

Reaction

preferential cleavage: Phe-/- > Tyr-/- > Trp-/- > Leu-/- =

Synonyms

alpha-chymase, beta-chymase, CAGE, Chy, chymase, chymase 1, chymostatin sensitive angiotensin generating enzyme, chymotrypsin-like protease, chymotryptic mast cell peptidase, CLP, CMA, CMA1, HAM1, mast cell chymase, mast cell chymases 4, mast cell protease, mast cell protease 1, mast cell protease 4, mast cell protease I, mast cell protease-2, mast cell protease-4, mast cell specific chymase, mast cell-derived chymase, mast-cell-derived chymase, MC chymase, MC protease 4, MC-chymase, MC-derived chymase, MC-specific chymase, MCC, MCP-1, MCP-2, MCP-4, MCP-5, MCP-8, MCP2, MCP4, Mcpt, MCPT-4, MCPT4, MMCP-1, mucosal mast cell protease, mucosal mast cell protease-1, proteinase, mast cell serine, chymase, RMCP I, skeletal muscle protease, skin chymotryptic proteinase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.39 chymase

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Results	in table
8	Activating Compound
15	AA Sequence
14	Application
1	CAS Registry Number
18	Cloned(Commentary)
4	Crystallization (Commentary)
2692	Disease/ Diagnostics
11	Expression
26	General Information
1	General Stability
127	IC50 Value
396	Inhibitors
16	kcat/KM [mM/s]
98	Ki Value [mM]
107	KM Value [mM]
13	Localization
32	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
149	Organism
22	PDB ID
8	pH Optimum
2	pH Range
3	pH Stability
11	Posttranslational Modification
10	Protein Variants
30	Purification (Commentary)
1	Reaction
1	Reaction Type
148	Reference
150	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
342	Substrates and Products (Substrate)
23	Subunits
133	Synonyms
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
107	Turnover Number [1/s]

Localization

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Localization on EC 3.4.21.39 - chymase

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cytoplasm

2 entries

cytoplasmic granule

Canis lupus familiaris

rat natural killer cell (RNK)-16 granules

42581

81385

additional information

Rattus norvegicus

the association of the enzyme with heparin proteoglycan may serve both to potentiate the catalytic activity of the enzyme and to increase the life-span of the chymase by preventing their inhibition after exocytosis

81376