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3.4.21.38: coagulation factor XIIa

This is an abbreviated version!
For detailed information about coagulation factor XIIa, go to the full flat file.

Word Map on EC 3.4.21.38

Reaction

selective cleavage of Arg-/-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa =

Synonyms

activated coagulation factor XII, activated factor XII, alpha-FXIIa, alphaFXIIa, beta-factor XIIa, beta-FXIIa, blood coagulation factor XII, blood-coagulation factor XII, activated beta, blood-coagulation factor XIIabeta, blood-coagulation factor XIIf, coagulation beta-factor XIIa, coagulation factor XII, coagulation factor XIIa, F12, factor XII, factor XII Osaka, factor XIIa, FXII, FXIIa, HAF, Hageman factor, Hageman factor beta-fragment, Hageman factor fragment HFf, Hagemann factor, kallikreinogen, activator, prealbumin activator, prekallikrein activator, single-chain FXII

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.38 coagulation factor XIIa

Purification

Purification on EC 3.4.21.38 - coagulation factor XIIa

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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
the cDNA of the zymogen domain of FXII is cloned into the pET-28a(+) vector and the plasmid is transformed into Escherichia coli strain BL21 (DE3) and overexpressed. The multi-disulfide, recombinant zymogen domain His(6)-beta-FXII is expressed as an inclusion body and purified by Ni2+-charged resin
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