3.4.21.38: coagulation factor XIIa

This is an abbreviated version!
For detailed information about coagulation factor XIIa, go to the full flat file.

Word Map on EC 3.4.21.38

3.4.21.38

kininogen

clot

platelet

thrombin

thrombosis

plasminogen

bradykinin

anticoagulant

bleeding

thromboplastin

fibrinolysis

fibrinogen

prothrombin

hereditary

heparin

fibrin

antithrombin

plasmin

kinin

procoagulant

angioedema

hemostasis

viii

kallikrein-kinin

amidolytic

autoactivation

zymogen

willebrand

kaolin

thromboembolic

antithrombotic

c1-inhibitor

fxia

d-dimers

c1-inh

hypercoagulability

antiphospholipid

thrombin-antithrombin

c1s

fletcher

2-antiplasmin

fibrinopeptide

euglobulins

c1-esterase

thrombophilia

synthesis

drug development

medicine

recalcification

recalcified

blood-contacting

bradykinin-mediated

icatibant

Reaction

selective cleavage of Arg-/-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa =

Synonyms

activated coagulation factor XII, activated factor XII, alpha-FXIIa, alphaFXIIa, beta-factor XIIa, beta-FXIIa, blood coagulation factor XII, blood-coagulation factor XII, activated beta, blood-coagulation factor XIIabeta, blood-coagulation factor XIIf, coagulation beta-factor XIIa, coagulation factor XII, coagulation factor XIIa, F12, factor XII, factor XII Osaka, factor XIIa, FXII, FXIIa, HAF, Hageman factor, Hageman factor beta-fragment, Hageman factor fragment HFf, Hagemann factor, kallikreinogen, activator, prealbumin activator, prekallikrein activator, single-chain FXII

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.38 coagulation factor XIIa

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Results	in table
27	Activating Compound
8	AA Sequence
14	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
3644	Disease/ Diagnostics
2	Expression
26	General Information
2	IC50 Value
44	Inhibitors
4	kcat/KM [mM/s]
31	KM Value [mM]
11	Localization
13	Molecular Weight [Da]
34	Natural Substrates/ Products (Substrates)
225	Organism
22	PDB ID
13	Posttranslational Modification
22	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
85	Reference
49	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
121	Substrates and Products (Substrate)
9	Subunits
118	Synonyms
1	Temperature Optimum [°C]
31	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.21.38 - coagulation factor XIIa

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0.012

benzyloxycarbonyl-Ala-Arg-SCH2C6H5