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3.4.21.36: pancreatic elastase

This is an abbreviated version!
For detailed information about pancreatic elastase, go to the full flat file.

Word Map on EC 3.4.21.36

Reaction

Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-/- =

Synonyms

CELA1, CELA3A, CELA3B, chymotrypsin-like elastase, EC 3.4.21.11, EC 3.4.4.7, elastase, elastase 1, elastase-1, elaszym, ELT, FE1, pancreatic elastase, pancreatic elastase 3, pancreatic elastase 3B, pancreatic elastase I, pancreatic elastase-1, pancreatopeptidase E, PE 3B, PE-1, peptidase, pancreato-, E, PPE, PRT-201, serine elastase, type I pancreatic elastase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.36 pancreatic elastase

Reference

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Reference on EC 3.4.21.36 - pancreatic elastase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mallory, P.A.; Travis, J.
Human pancreatic enzymes: purification and characterization of a nonelastolytic enzyme, protease E. resembling elastase
Biochemistry
14
722-730
1975
Homo sapiens
Manually annotated by BRENDA team
Szilagyi, C.M.; Sarfati, P.; Pradayrol, L.; Morisset, J.
Purification, characterization and substrate specificity of rat pancreatic elastase II
Biochim. Biophys. Acta
1251
55-65
1995
Rattus norvegicus
Manually annotated by BRENDA team
Powers, J.C.; Gupton, B.F.; Harley, A.D.; Nishino, N.; Whitley, R.J.
Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones
Biochim. Biophys. Acta
485
156-166
1977
Sus scrofa
Manually annotated by BRENDA team
Largman, C.
Isolation and characterization of rat pancreatic elastase
Biochemistry
22
3763-3770
1983
Rattus norvegicus
Manually annotated by BRENDA team
Fujimoto, K.; Ogawa, M.; Saito, N.; Kosaki, G.; Minamiura, N.; Yamamoto, T.
A novel method of isolation and some characteristic properties of human pancreatic elastases
Biochim. Biophys. Acta
612
262-267
1980
Homo sapiens
Manually annotated by BRENDA team
Katagiri, K.; Takeuchi, T.; Taniguchi, K.; Sasaki, M.
One step purification procedure of elastase from pancreatic powder by affinity chromatography
Anal. Biochem.
86
159-165
1978
Sus scrofa
Manually annotated by BRENDA team
Ohlsson, K.; Olsson, A.S.
Purification and partial characterization of human pancreatic elastase
Hoppe-Seyler's Z. Physiol. Chem.
357
1153-1161
1976
Homo sapiens
Manually annotated by BRENDA team
Largman, C.; Brodrick, J.W.; Geokas, M.C.
Purification and characterization of two human pancreatic elastases
Biochemistry
15
2491-2500
1976
Homo sapiens
Manually annotated by BRENDA team
Ardelt, W.
Partial purification and properties of porcine pancreatic elastase II
Biochim. Biophys. Acta
341
318-326
1974
Sus scrofa
Manually annotated by BRENDA team
Tsunemi, M.; Matsuura, Y.; Sakakibara, S.; Katsube, Y.
Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution
Biochemistry
35
11570-11576
1996
Sus scrofa (P00772), Sus scrofa
Manually annotated by BRENDA team
Tsunemi, M.; Matsuura, Y.; Sakakibara, S.; Katsube, Y.
Crystallization of a complex between an elastase-specific inhibitor elafin and porcine pancreatic elastase
J. Mol. Biol.
232
310-311
1993
Sus scrofa
Manually annotated by BRENDA team
Erlendsson, L.S.; Filippsusson, H.
Purification and characterization of ovine pancreatic elastase
Comp. Biochem. Physiol. B
120
549-557
1998
Ovis aries
Manually annotated by BRENDA team
Berglund, G.I.; Smalas, A.O.; Outzen, H.; Willassen, N.P.
Purification and characterization of pancreatic elastase from North Atlantic salmon (Salmo salar)
Mol. Mar. Biol. Biotechnol.
7
105-114
1998
Salmo salar
Manually annotated by BRENDA team
Wendorf, P.; Linder, D.; Sziegoleit, A.; Geyer, R.
Carbohydrate structure of human pancreatic elastase 1
Biochem. J.
278
505-514
1991
Homo sapiens
Manually annotated by BRENDA team
Smine, A.; Gal, Y.L.
Purification and characterization of two pancreatic elastase isoforms from dogfish (Scyliorhinus canicula)
Mol. Mar. Biol. Biotechnol.
4
295-303
1995
Scyliorhinus canicula
Manually annotated by BRENDA team
Smine, A.; Guerard, F.; Gal, Y.L.
Purification and characterization of pancreatic elastase from tuna (Thunnus albacora)
J. Mar. Biotechnol.
1
41-46
1993
Thunnus albacora
-
Manually annotated by BRENDA team
Berglund, G.I.; Willassen, N.P.; Hordvik, A.; Smalas, A.O.
Structure of native pancreatic elastase from north atlantic salmon at 1.6 A resolution
Acta Crystallogr. Sect. D
51
925-937
1995
Salmo salar
Manually annotated by BRENDA team
Mattos, C.; Gianmmona, D.A.; Petsko, G.A.; Ringe, D.
Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors
Biochemistry
34
3193-3203
1995
Sus scrofa
Manually annotated by BRENDA team
Bode, W.; Meyer Jr., E.; Powers, J.C.
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors
Biochemistry
28
1951-1963
1989
Sus scrofa
Manually annotated by BRENDA team
Wendorf, P.; Geyer, R.; Sziegoleit, A.; Linder, D.
Localization and characterization of the glycosylation site of human pancreatic elastase 1
FEBS Lett.
249
275-278
1989
Homo sapiens
Manually annotated by BRENDA team
Gildberg, A.; Overbo, K.
Purification and characterization of pancreatic elastase from Atlantic cod (Gadus morhua)
Comp. Biochem. Physiol. B
97
775-782
1990
Gadus morhua
Manually annotated by BRENDA team
Plaskon, R.R.; Kam, C.M.; Burgess, E.M.; Powers, J.C.; Suddath, F.L.
Michaelis complexes of porcine pancreatic elastase with 7-[(alkylcarbamoyl)amino]-4-chloro-3-ethoxyisocoumarins: translational sampling of inhibitor position and kinetic measurements
Proteins
13
141-151
1992
Sus scrofa
Manually annotated by BRENDA team
Wurtele, M.; Hahn, M.; Hilpert, K.; Hohne, W.
Atomic resolution structure of native porcine pancreatic elastase at 1.1 A
Acta Crystallogr. Sect. D
56
520-523
2000
Sus scrofa
-
Manually annotated by BRENDA team
Hilpert, K.; Schneider-Mergener, J.; Ay, J.
Crystallization and preliminary X-ray analysis of the complex of porcine pancreatic elastase and a hybrid squash inhibitor
Acta Crystallogr. Sect. D
58
672-674
2002
Sus scrofa (P00772), Sus scrofa
Manually annotated by BRENDA team
Ay, J.; Hilpert, K.; Krauss, N.; Schneider-Mergener, J.; Hohne, W.
Structure of a hybrid squash inhibitor in complex with porcine pancreatic elastase at 1.8 A resolution
Acta Crystallogr. Sect. D
59
247-254
2003
Sus scrofa
Manually annotated by BRENDA team
Jaspard, E.
Role of protein-solvent interactions in refolding. Effects of cosolvent additives on the renaturation of porcine pancreatic elastase at various pHs
Arch. Biochem. Biophys.
375
220-228
2000
Sus scrofa
Manually annotated by BRENDA team
Wright, P.A.; Wilmouth, R.C.; Clifton, I.J.; Schofield, C.J.
'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes
Biochem. J.
351
335-340
2000
Sus scrofa
-
Manually annotated by BRENDA team
Kinoshita, T.; Nakanishi, I.; Sato, A.; Tada, T.
True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor
Bioorg. Med. Chem. Lett.
13
21-24
2003
Sus scrofa (P00772), Sus scrofa
Manually annotated by BRENDA team
Matern, U.; Schleberger, C.; Jelakovic, S.; Weckesser, J.; Schulz, G.E.
Binding structure of elastase inhibitor scyptolin A
Chem. Biol.
10
997-1001
2003
Sus scrofa (P00772), Sus scrofa
Manually annotated by BRENDA team
Hilpert, K.; Wessner, H.; Schneider-Mergener, J.; Welfle, K.; Misselwitz, R.; Welfle, H.; Hocke, A.C.; Hippenstiel, S.; Hohne, W.
Design and characterization of a hybrid miniprotein that specifically inhibits porcine pancreatic elastase
J. Biol. Chem.
278
24986-24993
2003
Sus scrofa (P00772), Sus scrofa
Manually annotated by BRENDA team
Zani, M.L.; Nobar, S.M.; Lacour, S.A.; Lemoine, S.; Boudier, C.; Bieth, J.G.; Moreau, T.
Kinetics of the inhibition of neutrophil proteinases by recombinant elafin and pre-elafin (trappin-2) expressed in Pichia pastoris
Eur. J. Biochem.
271
2370-2378
2004
Homo sapiens
Manually annotated by BRENDA team
Ito, N.; Iwamori, Y.; Hanaoka, K.; Iwamori, M.
Inhibition of pancreatic elastase by sulfated lipids in the intestinal mucosa
J. Biochem.
123
107-114
1998
Sus scrofa
Manually annotated by BRENDA team
Kinoshita, T.; Yamaguchi, A.; Tada, T.
Tris(hydroxymethyl)aminomethane induces conformational change and crystal-packing contraction of porcine pancreatic elastase
Acta Crystallogr. Sect. F
62
623-626
2006
Sus scrofa, Sus scrofa (P00772)
Manually annotated by BRENDA team
Dementiev, A.; Dobo, J.; Gettins, P.G.
Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase
J. Biol. Chem.
281
3452-3457
2006
Sus scrofa, Sus scrofa (P00772)
Manually annotated by BRENDA team
Hilpert, K.; Wessner, H.; Scholz, C.; Scheerer, P.; Volkmer-Engert, R.; Kraubeta, N.
Crystallization and preliminary X-ray analysis of complexes of porcine pancreatic elastase with two natural inhibitors
Protein Pept. Lett.
11
393-399
2004
Sus scrofa
Manually annotated by BRENDA team
Tesch, L.D.; Raghavendra, M.P.; Bedsted-Faarvang, T.; Gettins, P.G.; Olson, S.T.
Specificity and reactive loop length requirements for crmA inhibition of serine proteases
Protein Sci.
14
533-542
2005
Sus scrofa
Manually annotated by BRENDA team
Kinoshita, T.; Tamada, T.; Imai, K.; Kurihara, K.; Ohhara, T.; Tada, T.; Kuroki, R.
Crystallization of porcine pancreatic elastase and a preliminary neutron diffraction experiment
Acta Crystallogr. Sect. F
63
315-317
2007
Sus scrofa (P00772), Sus scrofa
Manually annotated by BRENDA team
Walkowiak, J.; Wadolowska, L.; Szaflarska-Poplawska, A.; Lisowska, A.; Bugajewska, A.; Przyslawski, J.
The elimination of meat from the diet selectively decreases pancreatic elastase secretion
Br. J. Nutr.
98
154-158
2007
Homo sapiens
Manually annotated by BRENDA team
Chen, C.Y.; Tsai, W.L.; Wu, H.C.; Syu, M.J.; Wu, C.C.; Shiesh, S.C.
Diagnostic role of biliary pancreatic elastase for cholangiocarcinoma in patients with cholestasis
Clin. Chim. Acta
390
82-89
2008
Homo sapiens (Q9UNI1), Homo sapiens
Manually annotated by BRENDA team
Naruse, S.; Ishiguro, H.; Ko, S.B.; Yoshikawa, T.; Yamamoto, T.; Yamamoto, A.; Futakuchi, S.; Goto, H.; Saito, Y.; Takahashi, S.
Fecal pancreatic elastase: a reproducible marker for severe exocrine pancreatic insufficiency
J. Gastroenterol.
41
901-908
2006
Homo sapiens
Manually annotated by BRENDA team
Oliveira, T.F.; Mulchande, J.; Moreira, R.; Iley, J.; Archer, M.
Crystallization and preliminary diffraction studies of porcine pancreatic elastase in complex with a novel inhibitor
Protein Pept. Lett.
14
93-95
2007
Sus scrofa
Manually annotated by BRENDA team
Benahmed, N.A.; Manene, D.; Barbot, L.; Kapel, N.
Fecal pancreatic elastase in infants under 2 years of age
Ann. Biol. Clin. (Paris)
66
549-552
2008
Homo sapiens
Manually annotated by BRENDA team
Erickson, J.A.; Aldeen, W.E.; Grenache, D.G.; Ashwood, E.R.
Evaluation of a fecal pancreatic elastase-1 enzyme-linked immunosorbent assay: Assessment versus an established assay and implication in classifying pancreatic function
Clin. Chim. Acta
397
87-91
2008
Homo sapiens
Manually annotated by BRENDA team
Nadarajah, D.; Atkinson, M.A.; Huebner, P.; Starcher, B.
Enzyme kinetics and characterization of mouse pancreatic elastase
Connect. Tissue Res.
49
409-415
2008
Mus musculus
Manually annotated by BRENDA team
Suzuki, M.; Betsuyaku, T.; Ito, Y.; Nagai, K.; Odajima, N.; Moriyama, C.; Nasuhara, Y.; Nishimura, M.
Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice
Am. J. Physiol. Lung Cell Mol. Physiol.
296
L614-L623
2009
Sus scrofa
Manually annotated by BRENDA team
Conlon, J.M.; Raza, H.; Coquet, L.; Jouenne, T.; Leprince, J.; Vaudry, H.; King, J.D.
Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)
Comp. Biochem. Physiol. C
150
150-154
2009
Sus scrofa
Manually annotated by BRENDA team
Tamada, T.; Kinoshita, T.; Kurihara, K.; Adachi, M.; Ohhara, T.; Imai, K.; Kuroki, R.; Tada, T.
Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond
J. Am. Chem. Soc.
131
11033-11040
2009
Sus scrofa (P00772), Sus scrofa
Manually annotated by BRENDA team
Inoue, K.; Koike, E.; Yanagisawa, R.; Takano, H.
Extensive analysis of elastase-induced pulmonary emphysema in rats: ALP in the lung, a new biomarker for disease progression?
J. Clin. Biochem. Nutr.
46
168-176
2010
Sus scrofa
Manually annotated by BRENDA team
Kwan, J.C.; Taori, K.; Paul, V.J.; Luesch, H.
Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena
Mar. Drugs
7
528-538
2009
Sus scrofa
Manually annotated by BRENDA team
Rietschel, B.; Arrey, T.; Meyer, B.; Bornemann, S.; Schuerken, M.; Karas, M.; Poetsch, A.
Elastase digests: New ammunition for shotgun membrane proteomics
Mol. Cell. Proteomics
8
1029-1043
2009
Sus scrofa (P00772), Sus scrofa
Manually annotated by BRENDA team
Matthew, S.; Paul, V.J.; Luesch, H.
Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides
Phytochemistry
70
2058-2063
2009
Sus scrofa
Manually annotated by BRENDA team
Bras, N.F.; Goncalves, R.; Fernandes, P.A.; Mateus, N.; Ramos, M.J.; de Freitas, V.
Understanding the binding of procyanidins to pancreatic elastase by experimental and computational methods
Biochemistry
49
5097-5108
2010
Sus scrofa
Manually annotated by BRENDA team
Herzig, K.; Purhonen, A.; Räsänen, K.; Idziak, J.; Juvonen, P.; Phillps, R.; Walkowiak, J.
Fecal pancreatic elastase-1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus
BMC Geriatr.
11
4-4
2011
Homo sapiens
Manually annotated by BRENDA team
Bras, N.F.; Goncalves, R.; Mateus, N.; Fernandes, P.A.; Ramos, M.J.; de Freitas, V.
Inhibition of pancreatic elastase by polyphenolic compounds
J. Agric. Food Chem.
58
10668-10676
2010
Sus scrofa
Manually annotated by BRENDA team
Qamar, A.A.; Burke, S.K.; Lafleur, J.D.; Ding, B.C.; Bland, K.S.; Wong, M.D.; Gustafson, P.N.; Blair, A.T.; Franano, F.N.
The ability of serum from alpha 1-antitrypsin-deficient patients to inhibit PRT-201, a recombinant human type I pancreatic elastase
Biotechnol. Appl. Biochem.
59
22-28
2012
Homo sapiens
Manually annotated by BRENDA team
Qasim, M.A.; Wang, L.; Qasim, S.; Lu, S.; Lu, W.; Wynn, R.; Yi, Z.P.; Laskowski, M.
Additivity-based design of the strongest possible turkey ovomucoid third domain inhibitors for porcine pancreatic elastase (PPE) and Streptomyces griseus protease B (SGPB)
FEBS Lett.
587
3021-3026
2013
Sus scrofa
Manually annotated by BRENDA team
Burke, S.K.; Macdonald, K.; Moss, E.; Bunton, D.; Starcher, B.; Wong, M.D.; Bland, K.S.; Franano, F.N.
Effects of recombinant human type I pancreatic elastase on human atherosclerotic arteries
J. Cardiovasc. Pharmacol.
64
530-535
2014
Homo sapiens
Manually annotated by BRENDA team
Hofbauer, S.; Brito, J.A.; Mulchande, J.; Nogly, P.; Pessanha, M.; Moreira, R.; Archer, M.
Stabilization of porcine pancreatic elastase crystals by glutaraldehyde cross-linking
Acta Crystallogr. Sect. F
71
1346-1351
2015
Sus scrofa
Manually annotated by BRENDA team
Sadeghi-Kaji, S.; Shareghi, B.; Saboury, A.A.; Farhadian, S.
Spectroscopic and molecular docking studies on the interaction between spermidine and pancreatic elastase
Int. J. Biol. Macromol.
131
473-483
2019
Sus scrofa
Manually annotated by BRENDA team
Boros, E.; Szabo, A.; Zboray, K.; Heja, D.; Pal, G.; Sahin-Toth, M.
Overlapping specificity of duplicated human pancreatic elastase 3 isoforms and archetypal porcine elastase 1 provides clues to evolution of digestive enzymes
J. Biol. Chem.
292
2690-2702
2017
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Stergiou, P.Y.; Foukis, A.; Gkini, O.A.; Bieth, J.G.; Papamichael, E.M.
Kinetic and computational analysis of the reversible inhibition of porcine pancreatic elastase a structural and mechanistic approach
J. Enzyme Inhib. Med. Chem.
31
131-139
2016
Sus scrofa
Manually annotated by BRENDA team
Hernandez Gonzalez, J.E.; Garcia-Fernandez, R.; Valiente, P.A.
Polar desolvation and position 226 of pancreatic and neutrophil elastases are crucial to their affinity for the Kunitz-Type inhibitors ShPI-1 and ShPI-1/K13L
PLoS ONE
10
e0137787
2015
Sus scrofa (P00772), Sus scrofa
Manually annotated by BRENDA team