3.4.21.2: chymotrypsin C

This is an abbreviated version!
For detailed information about chymotrypsin C, go to the full flat file.

Reaction

Preferential cleavage: Leu-/-, Tyr-/-, Phe-/-, Met-/-, Trp-/-, Gln-/-, Asn-/- =

Synonyms

caldecrin, chymotrypsin C, chymotrypsinogen C, CTRC, elastase-associated acidic endopeptidase, elastase-like chymotrypsin, enzyme Y, Granzyme M, GrzM, Serum calcium-decreasing factor

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.2 chymotrypsin C

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Results	in table
7	AA Sequence
1	Application
1	CAS Registry Number
5	Cloned(Commentary)
1	Crystallization (Commentary)
182	Disease/ Diagnostics
1	Expression
5	General Information
1	General Stability
4	Inhibitors
34	kcat/KM [mM/s]
48	KM Value [mM]
3	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
20	Organism
2	PDB ID
4	Posttranslational Modification
34	Protein Variants
3	Purification (Commentary)
1	Reaction
3	Reaction Type
20	Reference
1	Renatured (Commentary)
8	Source Tissue
48	Substrates and Products (Substrate)
2	Subunits
18	Synonyms
47	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

50

acetyl-L-Leu methyl ester

Sus scrofa

-

-

95319

0.32

acetyl-L-Trp ethyl ester

Sus scrofa

-

-

95320

92

Acetyl-Tyr ethyl ester

Sus scrofa

-

-

95318

25.4

benzoyl-L-Leu ethyl ester

Sus scrofa

-

-

95320

28

benzoyl-L-Leu methyl ester

Sus scrofa

-

-

95319

1.7

benzoyl-L-Met ethyl ester

Sus scrofa

-

-

95320

1.55

benzoyl-L-Phe ethyl ester

Sus scrofa

-

-

95320

46 - 80

benzoyl-L-Tyr ethyl ester

2 entries

0.013

benzyloxycarbonyl-L-Leu-Gly amide

Sus scrofa

-

-

95320

170

N-Acetyl-Tyr ethyl ester

Sus scrofa

-

-

95319

11.7 - 24

N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

2 entries

0.3

succinyl-Ala-Ala-Pro-Ala 4-nitroanilide

Homo sapiens

Q99895

pH 8.0, temperature not specified in the publication

731789

3.6

succinyl-Ala-Ala-Pro-Asn 4-nitroanilide

Homo sapiens

Q99895

pH 8.0, temperature not specified in the publication

731789

1.1

succinyl-Ala-Ala-Pro-Gln 4-nitroanilide

Homo sapiens

Q99895

pH 8.0, temperature not specified in the publication

731789

0.03

succinyl-Ala-Ala-Pro-Ile 4-nitroanilide

Homo sapiens

Q99895

pH 8.0, temperature not specified in the publication

731789

9.2

succinyl-Ala-Ala-Pro-Leu 4-nitroanilide

Homo sapiens

Q99895

pH 8.0, temperature not specified in the publication

731789

14.9

succinyl-Ala-Ala-Pro-Met 4-nitroanilide

Homo sapiens

Q99895

pH 8.0, temperature not specified in the publication

731789

0.6 - 16.6

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

15 entries

0.6 - 42.2

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

10 entries

0.1

succinyl-Ala-Ala-Pro-Trp 4-nitroanilide

Homo sapiens

Q99895

pH 8.0, temperature not specified in the publication

731789

16.6

succinyl-Ala-Ala-Pro-Tyr 4-nitroanilide

Homo sapiens

Q99895

pH 8.0, temperature not specified in the publication

731789

0.05

succinyl-Ala-Ala-Pro-Val 4-nitroanilide

Homo sapiens

Q99895

pH 8.0, temperature not specified in the publication

731789

46

benzoyl-L-Tyr ethyl ester

Sus scrofa

-

-

95320

80

benzoyl-L-Tyr ethyl ester

Sus scrofa

-

-

95319

11.7

N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

wild-type enzyme, pH and temperature not specified in the publication

754977

24

N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

mutant enzyme T58M, pH and temperature not specified in the publication

754977

0.6

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant P249L, pH 8.0, 22°C

731886

1.4

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant V250E, pH 8.0, 22°C

731886

2.7

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant G217S, pH 8.0, 22°C

731886

3.5

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant Q178R, pH 8.0, 22°C

731886

10

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant G32V, pH 8.0, 22°C

731886

11.7

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant D35Y, pH 8.0, 22°C

731886

12.6

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant V235I, pH 8.0, 22°C

731886

13.2

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

pH 8.0, temperature not specified in the publication

731789

14.4

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant R37Q, pH 8.0, 22°C

731886

15

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

wild-type, pH 8.0, 22°C

731886

15.1

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant Q48R, pH 8.0, 22°C

731886

15.5

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant R254Q, pH 8.0, 22°C

731886

15.7

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant G18R, pH 8.0, 22°C

731886

16.6

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant A73T, pH 8.0, 22°C

731886

16.6

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

Homo sapiens

Q99895

mutant R254W, pH 8.0, 22°C

731886

0.6

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

pH 8.0, 22°C, mutant enzyme S239C

754111

10.3

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

pH 8.0, 22°C, mutant enzyme I209M

754111

11.7

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

pH 8.0, 22°C, mutant enzyme S239A

754111

14.1

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

pH 8.0, 22°C, mutant enzyme G214A

754111

14.7

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

pH 8.0, 22°C, mutant enzyme K247E

754111

15.1

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

pH 8.0, 22°C, mutant enzyme R80W

754111

15.4

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

pH 8.0, 22°C, wild-type enzyme

754111

16.5

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

pH 8.0, 22°C, mutant enzyme R80Q

754111

23.6

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

pH 8.0, 22°C, mutant enzyme G214M

754111

42.2

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

Homo sapiens

Q99895

pH 8.0, 22°C, mutant enzyme G214R

754111