3.4.21.2: chymotrypsin C
This is an abbreviated version!
For detailed information about chymotrypsin C, go to the full flat file.
Word Map on EC 3.4.21.2
Reaction
Preferential cleavage: Leu-/-, Tyr-/-, Phe-/-, Met-/-, Trp-/-, Gln-/-, Asn-/- =
Synonyms
caldecrin, chymotrypsin C, chymotrypsinogen C, CTRC, elastase-associated acidic endopeptidase, elastase-like chymotrypsin, enzyme Y, Granzyme M, GrzM, Serum calcium-decreasing factor
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Reference on EC 3.4.21.2 - chymotrypsin C
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sangild, P.T.; Weström, B.R.; Fowden, A.L.; Silver, M.
Developmental regulation of the porcine exocrine pancreas by glucocorticoids
J. Pediatr. Gastroenterol. Nutr.
19
204-212
1994
Sus scrofa
Thomson, A.; Denniss, I.S.
The identity of the elastase-associated acidic endopeptidase and chymotrypsin C from porcine pancreas
Biochim. Biophys. Acta
429
581-590
1976
Sus scrofa
Keil-Dlouha, V.; Puigserver, A.; Marie, A.; Keil, B.
On subunit II of bovine procarboxypeptidase A. Enzymatic specificity after tryptic activation
Biochim. Biophys. Acta
276
531-535
1972
Sus scrofa
Folk, J.E.; Schirmer, E.W.
Chymotrypsin C. I. Isolation of the zymogen and the active enzyme: preliminary structure and specificity studies
J. Biol. Chem.
240
181-192
1965
Sus scrofa
Folk, J.E.; Cole, P.W.
Chymotrypsin C. II. Enzymatic specificity toward several polypeptides
J. Biol. Chem.
240
193-197
1965
Sus scrofa
Peanasky, R.J.; Gratecos, D.; Baratti, J.; Rovery, M.
Mode of activation of N-terminal sequence of subunit II in bovine procarboxypeptidase A and of porcine chymotrypsinogen C
Biochim. Biophys. Acta
181
82-92
1969
Bos taurus, Sus scrofa
Gabert, V.M.; Jensen, M.S.; Weström, B.R.; Pierzynowski, S.G.
Electrophoretic separation of proteolytic enzymes in pancreatic juice collected with the pouch or catheter method
Int. J. Pancreatol.
22
39-43
1997
Sus scrofa
Nemoda, Z.; Sahin-Toth, M.
Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen
J. Biol. Chem.
281
11879-11886
2006
Homo sapiens
Pao L.I.; Sumaria N.; Kelly J.M.; van Dommelen S.; Cretney E.; Wallace M.E.; Anthony D.A.; Uldrich A.P.; Godfrey D.I.; Papadimitriou J.M.; Mullbacher A.; Degli-Esposti M.A.; Smyth M.J.
Functional analysis of granzyme M and its role in immunity to infection
J. Immunol.
175
3235-3243
2005
Mus musculus
Josephrajkumar, A.; Chakrabarty, R.; Thomas, G.
Purification of elastase-like chymotrypsin from cardamom shoot and capsule bore
Indian J. Exp. Biol.
45
998-1002
2007
Conogethes punctiferalis
Rosendahl, J.; Witt, H.; Szmola, R.; Bhatia, E.; Ozsvari, B.; Landt, O.; Schulz, H.U.; Gress, T.M.; Pfuetzer, R.; Loehr, M.; Kovacs, P.; Blueher, M.; Stumvoll, M.; Choudhuri, G.; Hegyi, P.; te Morsche, R.H.; Drenth, J.P.; Truninger, K.; Macek, M.; Puhl, G.; Witt, U.; Schmidt, H.; Buening, C.; Ockenga, J.
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
Nat. Genet.
40
78-82
2008
Homo sapiens
Szmola, R.; Sahin-Toth, M.
Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknechts enzyme Y
Proc. Natl. Acad. Sci. USA
104
11227-11232
2007
Homo sapiens (Q99895), Homo sapiens
Szmola, R.; Sahin-Toth, M.
Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells
Gut
59
365-372
2010
Homo sapiens
Szabo, A.; Sahin-Toth, M.
Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen
FEBS J.
279
4283-4292
2012
Homo sapiens (Q99895), Homo sapiens
Beer, S.; Zhou, J.; Szabo, A.; Keiles, S.; Chandak, G.R.; Witt, H.; Sahin-Toth, M.
Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk
Gut
62
1616-1624
2013
Homo sapiens (Q99895), Homo sapiens
Batra, J.; Szabo, A.; Caulfield, T.R.; Soares, A.S.; Sahin-Toth, M.; Radisky, E.S.
Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation
J. Biol. Chem.
288
9848-9859
2013
Homo sapiens (Q99895), Homo sapiens
Szabo, A.; Ludwig, M.; Hegyi, E.; Szepeova, R.; Witt, H.; Sahin-Toth, M.
Mesotrypsin signature mutation in a chymotrypsin C (CTRC) variant associated with chronic pancreatitis
J. Biol. Chem.
290
17282-17292
2015
Homo sapiens (Q99895), Homo sapiens
Jancso, Z.; Sahin-Toth, M.
Tighter control by chymotrypsin C (CTRC) explains lack of association between human anionic trypsinogen and hereditary pancreatitis
J. Biol. Chem.
291
12897-12905
2016
Homo sapiens (Q99895), Homo sapiens
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