3.4.21.2: chymotrypsin C

This is an abbreviated version!
For detailed information about chymotrypsin C, go to the full flat file.

Word Map on EC 3.4.21.2

3.4.21.2

pancreatitis

pancreas

spink1

zymogen

cftr

kazal

procarboxypeptidase

autoactivation

elastases

intra-pancreatic

chymotrypsin-type

rankl-stimulated

proproteinase

pancreatitis-associated

medicine

Reaction

Preferential cleavage: Leu-/-, Tyr-/-, Phe-/-, Met-/-, Trp-/-, Gln-/-, Asn-/- =

Synonyms

caldecrin, chymotrypsin C, chymotrypsinogen C, CTRC, elastase-associated acidic endopeptidase, elastase-like chymotrypsin, enzyme Y, Granzyme M, GrzM, Serum calcium-decreasing factor

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.2 chymotrypsin C

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Results	in table
7	AA Sequence
1	Application
1	CAS Registry Number
5	Cloned(Commentary)
1	Crystallization (Commentary)
182	Disease/ Diagnostics
1	Expression
5	General Information
1	General Stability
4	Inhibitors
34	kcat/KM [mM/s]
48	KM Value [mM]
3	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
20	Organism
2	PDB ID
4	Posttranslational Modification
34	Protein Variants
3	Purification (Commentary)
1	Reaction
3	Reaction Type
20	Reference
1	Renatured (Commentary)
8	Source Tissue
48	Substrates and Products (Substrate)
2	Subunits
18	Synonyms
47	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.21.2 - chymotrypsin C

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10

acetyl-L-Leu methyl ester

-

-

2.1

acetyl-L-Trp ethyl ester

-

-

13

Acetyl-Tyr ethyl ester

-

-

28

benzoyl-L-Leu ethyl ester

-

-

0.4

benzoyl-L-Leu methyl ester

-

-

10 - 17

benzoyl-L-Met ethyl ester

show

0.85

benzoyl-L-Phe ethyl ester

-

-

2

benzoyl-L-Tyr ethyl ester

-

-

15

benzyloxycarbonyl-L-Leu-Gly-amide

-

-

20

N-Acetyl-Tyr ethyl ester

-

-

0.0105 - 0.0134

N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

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0.000168

N-succinyl-L-Ala-Ala-Pro-Leu-p-nitroanilide

Conogethes punctiferalis

-

in 50 mM Tris-HCl (pH 8.0), with 20 mM CaCl2, at 37°C

0.392

succinyl-Ala-Ala-Pro-Ala 4-nitroanilide

pH 8.0, temperature not specified in the publication

3.452

succinyl-Ala-Ala-Pro-Asn 4-nitroanilide

pH 8.0, temperature not specified in the publication

0.738

succinyl-Ala-Ala-Pro-Gln 4-nitroanilide

pH 8.0, temperature not specified in the publication

0.0605

succinyl-Ala-Ala-Pro-Ile 4-nitroanilide

pH 8.0, temperature not specified in the publication

0.0118

succinyl-Ala-Ala-Pro-Leu 4-nitroanilide

pH 8.0, temperature not specified in the publication

0.0304

succinyl-Ala-Ala-Pro-Met 4-nitroanilide

pH 8.0, temperature not specified in the publication

0.013 - 1.539

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide

show

0.0153 - 0.0472

succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

show

0.0277

succinyl-Ala-Ala-Pro-Trp 4-nitroanilide

pH 8.0, temperature not specified in the publication

0.0196

succinyl-Ala-Ala-Pro-Tyr 4-nitroanilide

pH 8.0, temperature not specified in the publication

0.1504

succinyl-Ala-Ala-Pro-Val 4-nitroanilide

pH 8.0, temperature not specified in the publication

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Release 2023.1 (January 2023)