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3.4.21.19: glutamyl endopeptidase

This is an abbreviated version!
For detailed information about glutamyl endopeptidase, go to the full flat file.

Word Map on EC 3.4.21.19

Reaction

Preferential cleavage: Glu-/-, Asp-/- =

Synonyms

Alcalase, BIEP, BIGEP, BL-GSE, BLase, BS-GSE, endoproteinase Glu-C, endoproteinase V8, Glu C, Glu-C, Glu-endopeptidase, Glu-specific endopeptidase, GluScoh, GluScpr, GluSE, GluSsap, GluSW, glutamate specific endopeptidase, glutamate-specific proteinase, glutamate-specific serine endopeptidase, glutamic acid-specific endopeptidase, glutamic acid-specific proteinase, glutamic-acid-specific endopeptidase, glutamyl endopeptidase, glutamyl endopeptidase 2, glutamyl endopeptidase I, glutamyl specific endopeptidase, GluV8, GSE, gseBi gene product, protease V8, proteinase, glutamate-specific, proteinase, staphylococcal serine, SG-GSE, SGPE, Sspa, staphylococcal serine proteinase, V8 protease, V8 proteinase, V8-GSE, V8-protease, VSPase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.19 glutamyl endopeptidase

Inhibitors

Inhibitors on EC 3.4.21.19 - glutamyl endopeptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3,4-dichloroisocoumarin
0.3 mM, 62% inhibition of isoform -1S-SprE
4-(2-aminoethyl)benzenesulfonyl fluoride
4-chloromercuribenzoate
-
slight inhibition
antipain
-
87% inhibition
Cu2+
-
gradual inhibition of enzyme expression in recombinant Bacillus subtilis strain at 1-10 mM
diisopropyl fluorophosphate
diisopropylfluorophosphate
-
complete, irreversible inhibition
E-64
-
50% inhibition
Fe2+
-
gradual inhibition of enzyme expression in recombinant Bacillus subtilis strain at 1-10 mM
light
-
the activity of V8 protease is inhibited in a dose-dependent manner by exposure to laser light in the presence of light-activated antimicrobial agent methylene blue leading to degradation of the V8 protease that cannot be inhibited by the addition of a protease inhibitor
-
methylene blue
-
the activity of V8 protease is inhibited in a dose-dependent manner by exposure to laser light in the presence of light-activated antimicrobial agent methylene blue leaidng to degradation of the V8 protease that cannot be inhibited by the addition of a protease inhibitor
NaCl
1 mM, 80% inhibition of isoform -1S-SprE
Pefabloc SC
-
complete inhibition
phenylmethylsulfonyl fluoride
-
partial inhibition
PMSF
-
slight inhibition
SDS
-
partial inhibition. The enzyme is resistant to the SDS treatment in the presence of 10 mM CaCl2
tagged peptide GKH17
-
i.e. GKHKNKGKKNGKHNGWK,an antimicrobial peptide, derived from kininogen boosted through end tagging with hydrophobic oligopeptide stretches. Tagging results in enhanced killing of Gram-positive Staphylococcus aureus. Microbicidal potency increases with tag length, also in plasma, and is larger for Trp and Phe stretches than for aliphatic ones, overview
-
tagged peptide HKH17
-
i.e. HKHGHGHGKHKNKGKKN,an antimicrobial peptide, derived from kininogen boosted through end tagging with hydrophobic oligopeptide stretches. Tagging results in enhanced killing of Gram-positive Staphylococcus aureus. Microbicidal potency increases with tag length, also in plasma, and is larger for Trp and Phe stretches than for aliphatic ones, overview
-
Zn2+
-
gradual inhibition of enzyme expression in recombinant Bacillus subtilis strain at 1-10 mM
additional information
-