3.4.21.12: alpha-lytic endopeptidase

This is an abbreviated version, for detailed information about alpha-lytic endopeptidase, go to the full flat file.

Reaction

preferential cleavage: Ala-/-, Val-/- in bacterial cell walls, elastin and other proteins =

Synonyms

ALP, Alpha-lytic endopeptidase, alpha-lytic protease, alpha-lytic proteinase, alphaLP, Mycobacterium sorangium alpha-lytic proteinase, Myxobacter 495 alpha-lytic proteinase, Myxobacter alpha-lytic proteinase, proteinase, Mycobacterium sorangium alpha-lytic, proteinase, Myxobacter alpha-lytic

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.12 alpha-lytic endopeptidase

Cloned

Cloned on EC 3.4.21.12 - alpha-lytic endopeptidase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression of recombinant enzymes in Escherichia coli
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mutant enzyme precursor with a pro region lacking its last three amino acids: the turnover number of folding of the mutant enzyme is 1000fold lower that for the folding of the wild type enzyme. Mutant enzyme precursor with a pro region lacking its last three amino acids and two additional mutations, R102H and G134S: turnover number of folding of the mutant enzyme is 2fold higher than that of the wild-type enzyme
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