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3.4.21.112: site-1 protease

This is an abbreviated version!
For detailed information about site-1 protease, go to the full flat file.

Word Map on EC 3.4.21.112

Reaction

processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3 =

Synonyms

convertase site 1 protease, dS1P, hSKI-1, kexin, membrane-bound transcription factor protease, site-1, MEROPS S08.8063, PCSK8, prohormone convertase subtilisin-kexin isoenzyme-1, protease responsible for activating sigmaW, PrsW, S08.063, S1P, site 1 protease, site-1 protease, SK-1, SKI-1, SKI-1/S1P, SREBP site 1 protease, subtilisin kexin isoenzyme-1, subtilisin kexin isozyme 1/site 1 protease, subtilisin kexin isozyme-1, subtilisin kexin isozyme-1(SK-1)/site 1 protease (S1P), subtilisin kexin isozyme-1/site-1 protease, subtilisin kexin-isozyme-1, subtilisin-kexin isoenzyme-1, subtilisin-kexin-isozyme, subtilisin/kexin isozyme 1, YPDC

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.112 site-1 protease

Disease

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Disease on EC 3.4.21.112 - site-1 protease

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alkalosis
Alkalosis monitored by 31P NMR in a human glioma cell line exposed to the anti-tumor drug 1,3-bis(2-chloroethyl)-1-nitrosourea.
Carcinogenesis
Inhibition of the Prohormone Convertase Subtilisin-Kexin Isoenzyme-1 Induces Apoptosis in Human Melanoma Cells.
Carcinoma
SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth.
Carcinoma, Hepatocellular
Baicalin promoted site-2 protease and not site-1 protease in endoplasmic reticulum stress-induced apoptosis of human hepatocellular carcinoma cells.
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents.
Human Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance: A potential target for indirect-acting anti-dengue virus agents.
Carcinoma, Renal Cell
SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth.
Choriocarcinoma
The (pro)renin receptor and soluble (pro)renin receptor in choriocarcinoma.
Congenital Abnormalities
Patient with an autosomal-recessive MBTPS1-linked phenotype and clinical features of Silver-Russell syndrome.
Dengue
Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation.
Fatty Liver
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents.
Glioblastoma
Site-1 protease, a novel metabolic target for glioblastoma.
Glioma
Alkalosis monitored by 31P NMR in a human glioma cell line exposed to the anti-tumor drug 1,3-bis(2-chloroethyl)-1-nitrosourea.
Altered cytotoxicity of (2-chloroethyl)-3-sarcosinamide-1-nitrosourea in human glioma cell lines SK-MG-1 and SKI-1 correlates with differential transport kinetics.
Characterization of the catecholamine extraneuronal uptake2 carrier in human glioma cell lines SK-MG-1 and SKI-1 in relation to (2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarCNU) selective cytotoxicity.
Identification of a 116 kDa protein able to bind 1,3-bis(2-chloroethyl)-1-nitrosourea-damaged DNA as poly(ADP-ribose) polymerase.
Mechanisms of resistance to (2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarCNU) in sensitive and resistant human glioma cells.
Hemorrhagic Fever, American
Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito.
Hemorrhagic Fever, Crimean
Crimean-congo hemorrhagic fever virus glycoprotein precursor is cleaved by Furin-like and SKI-1 proteases to generate a novel 38-kilodalton glycoprotein.
Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity.
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.
Hepatitis C
SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replication.
Infections
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents.
Human Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance: A potential target for indirect-acting anti-dengue virus agents.
Novel circular, cyclic and acyclic ?(CH(2)O) containing peptide inhibitors of SKI-1/S1P: synthesis, kinetic and biochemical evaluations.
SKI-1/S1P inhibitor PF-429242 impairs the onset of HCV infection.
Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel anti-viral strategy against arenaviruses.
Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection.
Lymphocytic Choriomeningitis
Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P.
Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease.
The role of proteolytic processing and the stable signal peptide in expression of the Old World arenavirus envelope glycoprotein ectodomain.
Tropism of CPMV to Professional Antigen Presenting Cells Enables a Platform to Eliminate Chronic Infections.
Melanoma
Inhibition of the Prohormone Convertase Subtilisin-Kexin Isoenzyme-1 Induces Apoptosis in Human Melanoma Cells.
Neoplasm Metastasis
Inhibition of the Prohormone Convertase Subtilisin-Kexin Isoenzyme-1 Induces Apoptosis in Human Melanoma Cells.
Neoplasms
Inhibition of the Prohormone Convertase Subtilisin-Kexin Isoenzyme-1 Induces Apoptosis in Human Melanoma Cells.
SRC promotes survival and invasion of lung cancers with epidermal growth factor receptor abnormalities and is a potential candidate for molecular-targeted therapy.
Non-alcoholic Fatty Liver Disease
Regulation of SREBP-2 intracellular trafficking improves impaired autophagic flux and alleviates endoplasmic reticulum stress in NAFLD.
Prostatic Neoplasms
Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer.
Severe Fever with Thrombocytopenia Syndrome
The cholesterol, fatty acid and triglyceride synthesis pathways regulated by site 1 protease (S1P) are required for efficient replication of severe fever with thrombocytopenia syndrome virus.
Silver-Russell Syndrome
Patient with an autosomal-recessive MBTPS1-linked phenotype and clinical features of Silver-Russell syndrome.
site-1 protease deficiency
Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking.
Thrombocytopenia
The cholesterol, fatty acid and triglyceride synthesis pathways regulated by site 1 protease (S1P) are required for efficient replication of severe fever with thrombocytopenia syndrome virus.
Vaccinia
Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1.
Virus Diseases
C(2)-Symmetric azobenzene-amino acid conjugates and their inhibition of Subtilisin Kexin Isozyme-1.
Hypomorphic mutation in the site-1 protease mbtps1 endows resistance to persistent viral infection in a cell-specific manner.
Tropism of CPMV to Professional Antigen Presenting Cells Enables a Platform to Eliminate Chronic Infections.