3.4.21.111: aqualysin 1
This is an abbreviated version!
For detailed information about aqualysin 1, go to the full flat file.
Word Map on EC 3.4.21.111
-
3.4.21.111
-
thermus
-
aquaticus
-
subtilisin-type
-
proteinase
-
vibrio
-
pro-sequence
-
subtilisin-like
-
subtilisins
-
vpr
-
cooh-terminal
-
heat-stable
-
psychrotrophic
-
psychrophilic
-
subtilase
-
p-nitroanilides
-
baking
-
bake
-
subtilisin-related
-
food industry
-
biotechnology
- 3.4.21.111
- thermus
- aquaticus
-
subtilisin-type
- proteinase
- vibrio
-
pro-sequence
-
subtilisin-like
- subtilisins
- vpr
-
cooh-terminal
-
heat-stable
-
psychrotrophic
-
psychrophilic
-
subtilase
- p-nitroanilides
-
baking
-
bake
-
subtilisin-related
- food industry
- biotechnology
Reaction
exhibits low specificity towards esters of amino acids with small hydrophobic or aromatic residues at the P1 position =
Synonyms
Aq1, AQN, aqualysin I, S08.051
ECTree
3.4.21.111 aqualysin 1Advanced search results
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Substrates Products on EC 3.4.21.111 - aqualysin 1
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
N-benzyloxycarbonyl-L-leucyl-4-nitrophenyl ester + H2O
N-benzyloxycarbonyl-L-leucine + 4-nitrophenol
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
N-succinyl-Ala-Ala-Val-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Val + 4-nitroaniline
-
-
-
-
?
N-succinyl-Ala-Ala-Val-Ala-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Val-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Pro-Ala-4-nitroanilide + H2O
N-succinyl-Ala-Pro-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Gly-betaAla-Ala-4-nitroanilide + H2O
N-succinyl-Gly-betaAla-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Ile-betaAla-Ala-4-nitroanilide + H2O
N-succinyl-Ile-betaAla-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Leu-betaAla-Ala-4-nitroanilide + H2O
N-succinyl-Leu-betaAla-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-betaAla-Ala-4-nitroanilide + H2O
N-succinyl-Phe-betaAla-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Val-Leu-4-nitroanilide + H2O
N-succinyl-Phe-Val-Leu + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Val-Phe-4-nitroanilide + H2O
N-succinyl-Phe-Val-Phe + 4-nitroaniline
-
-
-
?
N-tert-butyloxycarbonyl-Val-Leu-Gly-Arg-4-nitroanilide + H2O
?
-
-
-
?
N-benzyloxycarbonyl-L-leucyl-4-nitrophenyl ester + H2O
N-benzyloxycarbonyl-L-leucine + 4-nitrophenol
-
-
-
?
N-benzyloxycarbonyl-L-leucyl-4-nitrophenyl ester + H2O
N-benzyloxycarbonyl-L-leucine + 4-nitrophenol
-
-
-
?
N-succinyl-Ala-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
-
synthetic substrate for elastase
-
?
N-succinyl-Ala-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
-
synthetic substrate for elastase
-
?
N-succinyl-Ala-Ala-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Phe + 4-nitroaniline
-
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
synthetic substrate for subtilisin
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Gly-Gly-Phe-4-nitroanilide + H2O
N-succinyl-Gly-Gly-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Gly-Gly-Phe-4-nitroanilide + H2O
N-succinyl-Gly-Gly-Phe + 4-nitroaniline
-
-
-
?
N-succinyl-Ile-Val-Ala-4-nitroanilide + H2O
N-succinyl-Ile-Val-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Ile-Val-Ala-4-nitroanilide + H2O
N-succinyl-Ile-Val-Ala + 4-nitroaniline
-
-
-
-
?
N-succinyl-Ile-Val-Ala-4-nitroanilide + H2O
N-succinyl-Ile-Val-Ala + 4-nitroaniline
-
-
-
-
?
N-succinyl-Phe-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Ala-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Ala-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Leu-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Leu-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Leu-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Leu-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Nle-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Nle-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Nle-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Nle-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Nle-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Nle-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Nle-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Nle-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Nle-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Nle-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Nle-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Nle-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Val-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Val-Ala + 4-nitroaniline
-
-
-
?
N-succinyl-Phe-Val-Ala-4-nitroanilide + H2O
N-succinyl-Phe-Val-Ala + 4-nitroaniline
-
-
-
?
oxidized insulin chain B + H2O
?
-
cleavage sites are not specific
-
?
oxidized insulin chain B + H2O
?
-
cleavage sites are not specific
-
?
Suc-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
Suc-Ala-Ala-Pro-Phe + p-nitroaniline
-
at 40°C, pH 7.5
-
-
?
Suc-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
Suc-Ala-Ala-Pro-Phe + p-nitroaniline
-
at 40°C, pH 7.5
-
-
?
additional information
?
-
-
enzyme has 3 subsites S1, S2 and S3 in its substrate binding site. S1 site prefers alanine and phenylalanine, S2 site prefers alanine and norleucine, S3 site prefers phenylalanine and isoleucine
-
?
additional information
?
-
-
preferentially hydrolyzes the ester bond of an alanine ester, but also shows relatively strong activity toward Gly, Trp, Phe and Tyr esters
-
?
additional information
?
-
-
requires its propeptide ProA to function as an intramolecular chaperone, N-terminal IMC can inhibit aqualysin activity and form a stable complex with subtilisin BPN'
-
?
additional information
?
-
-
exhibits specificity toward ester of amino acids with small haydrophobic or aromatic residues in P1
-
-
?
additional information
?
-
-
exhibits specificity toward ester of amino acids with small haydrophobic or aromatic residues in P1
-
-
?
additional information
?
-
-
enzyme has 3 subsites S1, S2 and S3 in its substrate binding site. S1 site prefers alanine and phenylalanine, S2 site prefers alanine and norleucine, S3 site prefers phenylalanine and isoleucine
-
?
additional information
?
-
-
preferentially hydrolyzes the ester bond of an alanine ester, but also shows relatively strong activity toward Gly, Trp, Phe and Tyr esters
-
?
