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3.4.21.111: aqualysin 1

This is an abbreviated version!
For detailed information about aqualysin 1, go to the full flat file.

Word Map on EC 3.4.21.111

Reaction

exhibits low specificity towards esters of amino acids with small hydrophobic or aromatic residues at the P1 position =

Synonyms

Aq1, AQN, aqualysin I, S08.051

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.111 aqualysin 1

Reference

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Reference on EC 3.4.21.111 - aqualysin 1

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Green, P.R.; Oliver, J.D.; Strickland, L.C.; Toerner, D.R.; Matsuzawa, H.; Ohta, T.
Purification, crystallization and preliminary X-ray investigation of aqualysin I, a heat-stable serine protease
Acta Crystallogr. Sect. D
D49
349-352
1993
Thermus aquaticus, Thermus aquaticus YT-1
Manually annotated by BRENDA team
Kim, D.W.; Lin, S.J.; Morita, S.; Terada, I.; Matsuzawa, H.
A carboxy-terminal pro-sequence of aqualysin I prevents proper folding of the protease domain on its secretion by Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
231
535-539
1997
Thermus aquaticus
Manually annotated by BRENDA team
Kim, D.W.; Matsuzawa, H.
Requirement for the COOH-terminal pro-sequence in the translocation of aqualysin I across the cytoplasmic membrane in Escherichia coli
Biochem. Biophys. Res. Commun.
277
216-220
2000
Thermus aquaticus, Thermus aquaticus YT-1
Manually annotated by BRENDA team
Tanaka, T.; Matsuzawa, H.; Ohta, T.
Engineering of S2 site of aqualysin I; alteration of P2 specificity by excluding P2 side chain
Biochemistry
37
17402-17407
1998
Thermus aquaticus
Manually annotated by BRENDA team
Lin, S.J.; Yoshimura, E.; Sakai, H.; Wakagi, T.; Matsuzawa, H.
Weakly bound calcium ions involved in the thermostability of aqualysin I, a heat-stable subtilisin-type protease of Thermus aquaticus YT-1
Biochim. Biophys. Acta
1433
132-138
1999
Thermus aquaticus, Thermus aquaticus YT-1
Manually annotated by BRENDA team
Lin, S.J.; Kim, D.W.; Ryugo, Y.; Wakagi, T.; Matsuzawa, H.
Increase of the protease activity of aqualysin I, a thermostable serine protease, by replacing Asn219 near the catalytic residue Ser222
Biosci. Biotechnol. Biochem.
61
718-719
1997
Thermus aquaticus
Manually annotated by BRENDA team
Tanaka, T.; Matsuzawa, H.; Ohta, T.
Stability of thermostable enzyme, aqualysin I; a subtilisin-type serine protease from Thermus aquaticus YT-1
Biosci. Biotechnol. Biochem.
62
1806-1808
1998
Thermus aquaticus
Manually annotated by BRENDA team
Tanaka, T.; Matsuzawa, H.; Kojima, S.; Kumagai, I.; Miura, K.; Ohta, T.
P1 specificity of aqualysin I (a subtilisin-type serine protease) from Thermus aquaticus YT-1, using P1-substituted derivatives of Streptomyces subtilisin inhibitor
Biosci. Biotechnol. Biochem.
62
2035-2038
1998
Thermus aquaticus, Thermus aquaticus YT-1
Manually annotated by BRENDA team
Tanaka, T.; Matsuzawa, H.; Ohta, T.
Substrate specificity of aqualysin I, a bacterial thermophilic alkaline serine protease from Thermus aquaticus YT-1: comparison with proteinase K, subtilisin BPN' and subtilisin Carlsberg
Biosci. Biotechnol. Biochem.
62
2161-2165
1998
Thermus aquaticus, Thermus aquaticus YT-1
Manually annotated by BRENDA team
Tanaka, T.; Matsuzawa, H.; Ohta, T.
Substrate specificity of aqualysin I altered by an organic solvent, DMSO
Biosci. Biotechnol. Biochem.
63
446-448
1999
Thermus aquaticus, Thermus aquaticus YT-1
Manually annotated by BRENDA team
Tanaka, T.; Kikuchi, Y.; Matsuzawa, H.; Ohta, T.
Application of a metal switch to aqualysin I, a subtilisin-type bacterial serine protease, to the S3 site residues, Ser102 and Gly131
Biosci. Biotechnol. Biochem.
64
2008-2011
2000
Thermus aquaticus
Manually annotated by BRENDA team
Matsuzawa, H.; Tokugawa, K.; Hamaoki, M.; Mizoguchi, M.; Taguchi, H.; Terada, I.; Kwon, S.T.; Ohta, T.
Purification and characterization of aqualysin I (a thermophilic alkaline serine protease) produced by Thermus aquaticus YT-1
Eur. J. Biochem.
171
441-447
1988
Thermus aquaticus, Thermus aquaticus YT-1
Manually annotated by BRENDA team
Lee, Y.C.; Koike, H.; Taguchi, H.; Ohta, T.; Matsuzawa, H.
Requirement of a COOH-terminal pro-sequence for the extracellular secretion of aqualysin I (a thermophilic subtilisin-type protease) in Thermus thermophilus
FEMS Microbiol. Lett.
120
69-74
1994
Thermus thermophilus
Manually annotated by BRENDA team
Kwon, S.T.; Matsuzawa, H.; Ohta, T.
Determination of the positions of the disulfide bonds in aqualysin I (a thermophilic alkaline serine protease) of Thermus aquaticus YT-1
J. Biochem.
104
557-559
1988
Thermus aquaticus, Thermus aquaticus YT-1
Manually annotated by BRENDA team
Tanaka, T.; Matsuzawa, H.; Ohta, T.
Identification and designing of the S3 site of aqualysin I, a thermophilic subtilisin-related serine protease
J. Biochem.
125
1016-1021
1999
Thermus aquaticus
Manually annotated by BRENDA team
Marie-Claire, C.; Yabuta, Y.; Suefuji, K.; Matsuzawa, H.; Shinde, U.
Folding pathway mediated by an intramolecular chaperone: the structural and functional characterization of the aqualysin I propeptide
J. Mol. Biol.
305
151-165
2001
Thermus aquaticus
Manually annotated by BRENDA team
Kurosaka, K.; Ohta, T.; Matsuzawa, H.
A 38 kDa precursor protein of aqualysin I (a thermophilic subtilisin-type protease) with a C-terminal extended sequence: its purification and in vitro processing
Mol. Microbiol.
20
385-389
1996
Thermus aquaticus
Manually annotated by BRENDA team
Matsuzawa, H.
Aqualysin I
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
2
1799-1800
2004
Thermus aquaticus, Thermus aquaticus YT-1
-
Manually annotated by BRENDA team
Sakaguchi, M.; Matsuzaki, M.; Niimiya, K.; Seino, J.; Sugahara, Y.; Kawakita, M.
Role of proline residues in conferring thermostability on aqualysin I
J. Biochem.
141
213-220
2007
Thermus aquaticus, Thermus aquaticus YT-1
Manually annotated by BRENDA team
Sakaguchi, M.; Takezawa, M.; Nakazawa, R.; Nozawa, K.; Kusakawa, T.; Nagasawa, T.; Sugahara, Y.; Kawakita, M.
Role of disulfide bonds in a thermophilic serine protease aqualysin I from Thermus aquaticus YT-1
J. Biochem.
143
625-632
2008
Thermus aquaticus, Thermus aquaticus YT-1
Manually annotated by BRENDA team
Sigurdardottir, A.G.; Arnorsdottir, J.; Thorbjarnardottir, S.H.; Eggertsson, G.; Suhre, K.; Kristjansson, M.M.
Characteristics of mutants designed to incorporate a new ion pair into the structure of a cold adapted subtilisin-like serine proteinase
Biochim. Biophys. Acta
1794
512-518
2009
Thermus aquaticus
Manually annotated by BRENDA team
Sakaguchi, M.; Niimiya, K.; Takezawa, M.; Toki, T.; Sugahara, Y.; Kawakita, M.
Construction of an expression system for aqualysin I in Escherichia coli that gives a markedly improved yield of the enzyme protein
Biosci. Biotechnol. Biochem.
72
2012-2018
2008
Thermus aquaticus
Manually annotated by BRENDA team
Sakaguchi, M.; Osaku, K.; Maejima, S.; Ohno, N.; Sugahara, Y.; Oyama, F.; Kawakita, M.
Highly conserved salt bridge stabilizes a proteinase K subfamily enzyme, Aqualysin I, from Thermus aquaticus YT-1
AMB Express
4
59
2014
Thermus aquaticus (P08594), Thermus aquaticus YT-1 (P08594), Thermus aquaticus YT-1
Manually annotated by BRENDA team
Verbauwhede, A.E.; Lambrecht, M.A.; Fierens, E.; Hermans, S.; Shegay, O.; Brijs, K.; Delcour, J.A.
Thermo-reversible inhibition makes aqualysin 1 from Thermus aquaticus a potent tool for studying the contribution of the wheat gluten network to the crumb texture of fresh bread
Food Chem.
264
118-125
2018
Thermus aquaticus
Manually annotated by BRENDA team
Verbauwhede, A.; Lambrecht, M.; Fierens, E.; Shegay, O.; Brijs, K.; Delcour, J.
Impact of aqualysin 1 peptidase from Thermus aquaticus on molecular scale changes in the wheat gluten network during bread baking
Food Chem.
295
599-606
2019
Thermus aquaticus
Manually annotated by BRENDA team