3.4.21.108: HtrA2 peptidase

This is an abbreviated version!
For detailed information about HtrA2 peptidase, go to the full flat file.

Reaction

cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues =

Synonyms

DegP, dOmi/HtrA2, high temperature requirement A serine protease, high temperature requirement A2, high temperature requirement A2 protease, high temperature requirement A2 serine protease, high temperature requirement protein A2, high-temperature requirement factor A2, HtrA protease, HtrA/DegP, HtrA2, HtrA2 protease, HtrA2 serine protease, HtrA2(Omi), HtrA2/Omi, HtrA2/Omi serine protease, Nma11p, Omi, Omi protease, Omi/HtrA2, Omi/HtrA2 protease, Omi/HtrA2 serine protease, pro-apoptotic serine protease, S01.278, serine protease, serine protease HtrA2, serine protease HtrA2/Omi, serine protease Omi/HtrA2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.108 HtrA2 peptidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
43	Activating Compound
714	AA Sequence
37	Application
1	CAS Registry Number
48	Cloned(Commentary)
6	Crystallization (Commentary)
418	Disease/ Diagnostics
7	Expression
30	General Information
2	General Stability
1	IC50 Value
45	Inhibitors
34	kcat/KM [mM/s]
34	KM Value [mM]
118	Localization
43	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
136	Organism
16	PDB ID
5	pH Optimum
2	pI Value
8	Posttranslational Modification
115	Protein Variants
28	Purification (Commentary)
1	Reaction
51	Reaction Type
128	Reference
121	Source Tissue
1	Specific Activity [micromol/min/mg]
5	Storage Stability
153	Substrates and Products (Substrate)
6	Subunits
203	Synonyms
6	Temperature Optimum [°C]
3	Temperature Range [°C]
3	Temperature Stability [°C]
23	Turnover Number [1/s]

Temperature Range

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Temperature Range on EC 3.4.21.108 - HtrA2 peptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Temperature Range Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

TEMPERATURE RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

20

Homo sapiens

O43464

activity is practically negligible at 20 °C

731620

25 - 55

Homo sapiens

-

enzyme activity rapidly increases with temperature and it drastically decreases at and above 60°C, no significant change in secondary structure from 25-70 °C or in the oligomeric size between 25-55 °C, but significant change in tertiary level from 25-60 °C

667757

additional information

Escherichia coli

-

functions as a chaperonin at normal temperatures, but relies on its proteolytic activity to prevent the accumulation of misfolded proteins in the periplasmic space at higher temperatures

686002