3.4.21.108: HtrA2 peptidase
This is an abbreviated version!
For detailed information about HtrA2 peptidase, go to the full flat file.
Word Map on EC 3.4.21.108
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3.4.21.108
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xiap
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bcl-2
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parkinson
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proapoptotic
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caspases
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caspase-independent
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aif
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x-linked
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medicine
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apoptosis-inducing
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intermembrane
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htras
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pink1
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apoptogenic
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iap-binding
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apoptosome
- 3.4.21.108
- xiap
- bcl-2
- parkinson
-
proapoptotic
-
caspases
-
caspase-independent
- aif
-
x-linked
- medicine
-
apoptosis-inducing
-
intermembrane
-
htras
- pink1
-
apoptogenic
-
iap-binding
- apoptosome
Reaction
cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues =
Synonyms
DegP, dOmi/HtrA2, high temperature requirement A serine protease, high temperature requirement A2, high temperature requirement A2 protease, high temperature requirement A2 serine protease, high temperature requirement protein A2, high-temperature requirement factor A2, HtrA protease, HtrA/DegP, HtrA2, HtrA2 protease, HtrA2 serine protease, HtrA2(Omi), HtrA2/Omi, HtrA2/Omi serine protease, Nma11p, Omi, Omi protease, Omi/HtrA2, Omi/HtrA2 protease, Omi/HtrA2 serine protease, pro-apoptotic serine protease, S01.278, serine protease, serine protease HtrA2, serine protease HtrA2/Omi, serine protease Omi/HtrA2
ECTree
3.4.21.108 HtrA2 peptidaseAdvanced search results
results (
results (KCat KM Value
KCat KM Value on EC 3.4.21.108 - HtrA2 peptidase
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kcat/KM VALUE [1/mMs-1] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
31.13
(7-methoxycoumarin-4-yl)AIRRVSYSF-(5-amino-2-nitro)benzamide
pH 8.0, 45°C
5.623
2-aminobenzoic acid-Ile-Met-Thr-Abu-Tyr-Met-His-Tyr(3-NO2)-NH2
pH 8.0, 37°C
14.53
2-aminobenzoic acid-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
pH 8.0, 37°C
1.588
2-aminobenzoic acid-Ile-Met-Thr-Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2
pH 8.0, 37°C
0.028
2-aminobenzoic acid-Ile-Met-Thr-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2
pH 8.0, 37°C
4.17
2-aminobenzoic acid-Ile-Met-Val-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
pH 8.0, 37°C
0.681
2-aminobenzoic acid-Ile-Met-Val-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2
pH 8.0, 37°C
5.62
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-His-Tyr(3-NO2)-NH2
pH 8.0, temperature not specified in the publication
14.53
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2)
pH 8.0, temperature not specified in the publication
1.58
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2
pH 8.0, temperature not specified in the publication
4.117
2-aminobenzoyl-Ile-Met-Val-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
pH 8.0, temperature not specified in the publication
0.68
2-aminobenzoyl-Ile-Met-Val-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2
pH 8.0, temperature not specified in the publication
30.27
Ala(7-methoxycoumarin-4-acetic acid)-IRRVSYSF-(5-amido-2-nitrobenzamide)
variant lacking the N-terminal domain, pH 7.5, temperature not specified in the publication
33.03
Ala(7-methoxycoumarin-4-acetic acid)-IRRVSYSF-(5-amido-2-nitrobenzamide)
protease domain, pH 7.5, temperature not specified in the publication
40.5
Ala(7-methoxycoumarin-4-acetic acid)-IRRVSYSF-(5-amido-2-nitrobenzamide)
short natural isoform lacking the N-terminal domain, pH 7.5, temperature not specified in the publication
0.26
beta-casein
mutant G230A, presence of inhibitor of apoptosis domain BIR3, 37°C, pH 7.8
-
0.29
beta-casein
PDZ domain deletion mutant, Hill constant 1.7, 37°C, pH 7.8
-
0.44
beta-casein
mutant G230A, presence of inhibitor of apoptosis domain BIR2, 37°C, pH 7.8
-
0.51
beta-casein
mutant G230A, presence of inhibitor of apoptosis protein, 37°C, pH 7.8
-
0.51
beta-casein
PDZ domain deletion mutant, Hill constant 1.5, presence of inhibitor of apoptosis domain BIR3, 37°C, pH 7.8
-
0.62
beta-casein
PDZ domain deletion mutant, Hill constant 1.4, presence of inhibitor of apoptosis domain BIR2, 37°C, pH 7.8
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0.8
beta-casein
PDZ domain deletion mutant, Hill constant 1.5, presence of inhibitor of apoptosis protein, 37°C, pH 7.8
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1.29
beta-casein
mutant comprising N-terminal and serine protease domains, pH 8.0, 37°C
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3.1
beta-casein
wild-type, Hill constant 1.8, presence of inhibitor of apoptosis domain BIR3, 37°C, pH 7.8
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3.8
beta-casein
wild-type, Hill constant 1.6, presence of inhibitor of apoptosis domain BIR2, 37°C, pH 7.8
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4.7
beta-casein
wild-type, Hill constant 1.5, presence of inhibitor of apoptosis protein, 37°C, pH 7.8
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