3.4.21.108: HtrA2 peptidase

This is an abbreviated version!
For detailed information about HtrA2 peptidase, go to the full flat file.

Reaction

cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues =

Synonyms

DegP, dOmi/HtrA2, high temperature requirement A serine protease, high temperature requirement A2, high temperature requirement A2 protease, high temperature requirement A2 serine protease, high temperature requirement protein A2, high-temperature requirement factor A2, HtrA protease, HtrA/DegP, HtrA2, HtrA2 protease, HtrA2 serine protease, HtrA2(Omi), HtrA2/Omi, HtrA2/Omi serine protease, Nma11p, Omi, Omi protease, Omi/HtrA2, Omi/HtrA2 protease, Omi/HtrA2 serine protease, pro-apoptotic serine protease, S01.278, serine protease, serine protease HtrA2, serine protease HtrA2/Omi, serine protease Omi/HtrA2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.108 HtrA2 peptidase

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Results	in table
43	Activating Compound
714	AA Sequence
37	Application
1	CAS Registry Number
48	Cloned(Commentary)
6	Crystallization (Commentary)
418	Disease/ Diagnostics
7	Expression
30	General Information
2	General Stability
1	IC50 Value
45	Inhibitors
34	kcat/KM [mM/s]
34	KM Value [mM]
118	Localization
43	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
136	Organism
16	PDB ID
5	pH Optimum
2	pI Value
8	Posttranslational Modification
115	Protein Variants
28	Purification (Commentary)
1	Reaction
51	Reaction Type
128	Reference
121	Source Tissue
1	Specific Activity [micromol/min/mg]
5	Storage Stability
153	Substrates and Products (Substrate)
6	Subunits
203	Synonyms
6	Temperature Optimum [°C]
3	Temperature Range [°C]
3	Temperature Stability [°C]
23	Turnover Number [1/s]

Expression

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Expression on EC 3.4.21.108 - HtrA2 peptidase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

124 endometrial tissue specimens including 88 cancers and 36 normal endometria are analyzed. HtrA2 protein levels are significantly lower in endometrial cancer cells compared to normal cells

Homo sapiens

-

710167

ablation of HtrA2 activity using RNAi in the human osteosarcoma U2OS cells prevents the cleavage of Wilms'tumor suppressor protein WT1 under apoptotic conditions

Homo sapiens

-

709955

after specific HtrA2 downregulation using RNAi, increased cell viability is measured in H2O2-treated ARPE-19 cells

Mus musculus

-

708821

Omi/HtrA2 siRNA decreases the cleavage of annexin A2 lung epithelial adenocarcinoma cell A549 under both serum withdrawal and cisplatin treatment

Homo sapiens

-

709872

S-nitrosoglutathione treatment significantly decreases mitochondrial Omi/HtrA2 content after 8 h of exposure in endothelial cells

Homo sapiens

-

713539

S-nitrosoglutathione treatment significantly increases cytosolic Omi/HtrA2 content after 8 h of exposure in endothelial cells

Homo sapiens

-

713539

the expression level of HtrA2/Omi decreases with endoplasmic reticulum stress induction in 6-hydroxydopamine-treated SH-SY5Y cells

Homo sapiens

O43464

732357