3.4.21.107: peptidase Do

This is an abbreviated version!
For detailed information about peptidase Do, go to the full flat file.

Reaction

acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-/-Val =

Synonyms

bacterial PQC factor, BB_0104, BCAL2829, CD630_32840, Deg1, DEG2, DEG5, DEG7, DEG8, Deg9, DegP, DegP protease, DegP/HtrA, DegQ, DegS, DepP9, Do, Do protease, HhoA, HhoB, high temperature requirement A, high temperature requirement A protease, high temperature requirement A1, high temperature requirement factor A, high-temperature requirement A, high-temperature requirement A protease, high-temperature requirement A-1, high-temperature requirement A1, high-temperature requirement A1 protease, high-temperature requirement factor A, HtrA, HtrA (DegP) protease, HtrA heat shock protease, HtrA protease, HTRA serine peptidase 1, HtrA-like protease, HtrA/DegP, HtrA1, HtrA2, HtrA3, HTRA4, MAL8P1.126, More, MucD, Nma111p, Omi/HtrA protease orthologue Ynm3p, protease do, protease Do-like 5, protease Do-like 8, PRSS11, S01.273, serine protease, serine protease HtrA, serine protease HtrA1, YNL123w

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.107 peptidase Do

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Results	in table
32	Activating Compound
31490	AA Sequence
17	Application
1	CAS Registry Number
46	Cloned(Commentary)
2	Cofactor
11	Crystallization (Commentary)
1880	Disease/ Diagnostics
17	Expression
58	General Information
2	General Stability
1	IC50 Value
36	Inhibitors
1	kcat/KM [mM/s]
2	KM Value [mM]
52	Localization
16	Metals/Ions
38	Molecular Weight [Da]
123	Natural Substrates/ Products (Substrates)
228	Organism
99	PDB ID
16	pH Optimum
5	pH Range
1	pI Value
2	Posttranslational Modification
141	Protein Variants
31	Purification (Commentary)
2	Reaction
56	Reaction Type
144	Reference
64	Source Tissue
7	Specific Activity [micromol/min/mg]
248	Substrates and Products (Substrate)
47	Subunits
204	Synonyms
17	Temperature Optimum [°C]
11	Temperature Range [°C]
13	Temperature Stability [°C]

Temperature Range

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Temperature Range on EC 3.4.21.107 - peptidase Do

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TEMPERATURE RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

20 - 30

Escherichia coli

-

almost no activity below 20°C, activity rapidly increases above 30°C

653189

20 - 85

Bacillus subtilis

-

at least 50% of maximum activity

732347

30 - 40

Streptococcus pyogenes

-

-

668906

30 - 42

Escherichia coli

-

enzyme activity is constant within this temperature range

651342

34 - 55

Chlamydia trachomatis

-

low activity below 34°C, rapid loss of activity at 55°C

683471

37 - 44

Campylobacter jejuni

-

the HtrA mutant forms colonies with the same frequency as the wild type at 37°C and 42°C, the ability of the mutant to form colonies at 44°C was greatly reduced as compared to the wild type

667253

37 - 45

2 entries

37 - 55

Escherichia coli

-

activity rapidly increases with temperature

651849

40 - 50

Edwardsiella tarda

D6BU29

-

712048

44

Escherichia coli

-

at 44 °C function of DegP in mutant strain CLC198 can be complemented by HtrA2

667757

37 - 45

Escherichia coli

-

enzyme is more efficient at 45°C than at 37°C

653253

37 - 45

Escherichia coli

-

no change of cell density of wild type, cell density of the mutant rapidly falls, protease Do essential for the cell's survival at high temperatures

667371