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3.4.21.107: peptidase Do

This is an abbreviated version!
For detailed information about peptidase Do, go to the full flat file.

Word Map on EC 3.4.21.107

Reaction

acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-/-Val =

Synonyms

bacterial PQC factor, BB_0104, BCAL2829, CD630_32840, Deg1, DEG2, DEG5, DEG7, DEG8, Deg9, DegP, DegP protease, DegP/HtrA, DegQ, DegS, DepP9, Do, Do protease, HhoA, HhoB, high temperature requirement A, high temperature requirement A protease, high temperature requirement A1, high temperature requirement factor A, high-temperature requirement A, high-temperature requirement A protease, high-temperature requirement A-1, high-temperature requirement A1, high-temperature requirement A1 protease, high-temperature requirement factor A, HtrA, HtrA (DegP) protease, HtrA heat shock protease, HtrA protease, HTRA serine peptidase 1, HtrA-like protease, HtrA/DegP, HtrA1, HtrA2, HtrA3, HTRA4, MAL8P1.126, More, MucD, Nma111p, Omi/HtrA protease orthologue Ynm3p, protease do, protease Do-like 5, protease Do-like 8, PRSS11, S01.273, serine protease, serine protease HtrA, serine protease HtrA1, YNL123w

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.107 peptidase Do

Expression

Expression on EC 3.4.21.107 - peptidase Do

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
during acid stress, htrA is overexpressed in Streptococcus mutans strains K7 and UA159
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expression is significantly induced in parasite culture upon heat shock/oxidative stress
HTRA1 expression is increased in the pathogenesis of age-related macular degeneration
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HTRA1 expression is upregulated in osteoarthritic joints, HTRA1 mRNA is increased by transforming growth factor-beta treatment (1 ng/ml for 24 h) in human primary chondrocytes
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HtrA1 levels are highly elevated (about 7.8fold) in osteoarthritic cartilage
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HtrA1 mRNA and protein levels are significantly decreased in endometrial cancer compared to normal tissues
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HTRA1 mRNA levels are 3fold higher in primary RPE cells homozygous for the HTRA1 promoter risk allele (rs11200638 -512 G>A), than in RPE cells with the wild type allele. This translates into a 2fold increase in HTRA1 secretion by RPE cells with the risk genotype
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HTRA3 expression is initiated on day 12 after birth and upregulated during ovarian maturation with the highest levels found in the mature cycling ovary
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HtrA3 expression is reduced or completely lost in over 50% of lung cancer cell lines and primary lung tumors from heavy smokers. An increased frequency of methylation within the first exon of HtrA3 corresponds to a loss of HtrA3 expression, particularly in tumors from smokers. 4-(methylnitrosamino)-I-(3-pyridyl)-1-butanone results in HtrA3 downregulation with a corresponding increase in methylation. HtrA3 expression is reduced after 15 days of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone treatment (0.01 mM)
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in response to loss of anchorage, HtrA1 expression is upregulated in SKOV-3 cells, resulting in autocatalytic activation. Expression of HtrA1 is upregulated during anoikis
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isoform HTRA1 mRNA and HTRA1 activity are up-regulated in response to elevated tau concentrations
protease activity stimulates HtrA production and oligomer formation
RpoE is released from the membrane to function as a sigma factor that induces degP expression. On the protein level, DegP activity is upregulated by C-termini of omps as well as misfolded periplasmic proteins
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the activity of isoform HTRA2 is stimulated by phosphorylation downstream of PTEN-induced putative kinase 1 and the p38 stress kinase pathway
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the growth differentiation factor 6 age-related macular degeneration risk allele (rs6982567 A) is associated with 70% increased expression of HTRA1. The HTRA1 age-related macular degeneration risk allele (rs10490924 T) is associated with 94% increased HTRA1 expression
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treatment of HtrA3-deficient cell lines with 5-aza-2’-deoxycytidine results in a dose-dependent increase in HtrA3 transcription. HtrA3 expression is induced by the histone deacetylase inhibitor LBH589
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