3.4.21.102: C-terminal processing peptidase
This is an abbreviated version!
For detailed information about C-terminal processing peptidase, go to the full flat file.
Word Map on EC 3.4.21.102
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3.4.21.102
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krabbe
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thylakoids
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leukodystrophy
-
globoid
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twitcher
-
psychosine
-
galactosylceramide
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photoinhibition
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oxygen-evolving
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galactocerebroside
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agriculture
-
drug development
- 3.4.21.102
-
krabbe
- thylakoids
-
leukodystrophy
-
globoid
-
twitcher
- psychosine
- galactosylceramide
-
photoinhibition
-
oxygen-evolving
- galactocerebroside
- agriculture
- drug development
Reaction
the enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala-/-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. In the plant chloroplast, the enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II =
Synonyms
At4g17740, C-terminal processing peptidase, C-terminal processing protease, C-terminal protease, carboxy terminal-processing proteinase, carboxyl terminal processing protease of D1 protein, carboxyl-terminal processing protease, carboxyl-terminal protease, carboxyl-terminal-processing peptidase 2, carboxyterminal processing protease, carboxyterminal processing protease of D1 protein, chloroplast processing enzyme, chloroplast protein precursor processing proteinase, CPE, CtpA, CtpA gene product, CtpB, D1 preprotein-processing proteinase, D1 protein-processing enzyme, D1P, More, PA5734, photosystem D1 protein precursor carboxyl-terminal processing protease, photosystem II D1 C-terminal processing protease, photosystem II D1 protein, photosystem II D1 protein processing proteinase, photosystem II protein D1, photosystem II protein D1 2, PrC, Prc protease, PRC protein, processing peptidase, protease Re, proteinase CtpA, proteinase, chloroplast protein precursor-processing, PsbA4, PXO_04290, SPP, stromal processing peptidase, tail-specific protease, thylakoid protein precursor processing peptidase, Tsp protease
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Reference on EC 3.4.21.102 - C-terminal processing peptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Keiler, K.C.; Sauer, R.T.
Tsp protease
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
460-461
1998
Bacillus subtilis, Bartonella bacilliformis, Escherichia coli, Haemophilus influenzae, Neisseria gonorrhoeae
-
Beebe, K.D.; Shin, J.N.; Peng, J.; Chaudhury, C.; Khera, J.; Pei, D.H.
Substrate recognition through a PDZ domain in tail-specific protease
Biochemistry
39
3149-3155
2000
Escherichia coli
Liao, D.I.; Qian, J.; Chisholm, D.A.; Jordan, D.B.; Diner, B.A.
Crystal structures of the photosystem II D1 C-terminal processing protease
Nat. Struct. Biol.
7
749-753
2000
Tetradesmus obliquus
Keiler, K.C.; Sauer, R.T.
Sequence determinants of C-terminal substrate recognition by the Tsp protease
J. Biol. Chem.
271
2589-2593
1996
Escherichia coli
Keiler, K.C.; Silber, K.R.; Downard, K.M.; Papayannopoulos, I.A.; Biemann, K.; Sauer, R.T.
C-terminal specific protein degradation: activity and substrate specificity of the Tsp protease
Protein Sci.
4
1507-1515
1995
Escherichia coli
Keiler, K.C.; Sauer, R.T.
Identification of active site residues of the Tsp protease
J. Biol. Chem.
270
28864-28868
1995
Escherichia coli (P23865)
Silber, K.R.; Keiler, K.C.; Sauer, R.T.
Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini
Proc. Natl. Acad. Sci. USA
89
295-299
1992
Escherichia coli
Shestakov, S.V.; Anbudurai, P.R.; Stanbekova, G.E.; Gadzhiev, A.; Lind, L.K.; Pakrasi, H.B.
Molecular cloning and characterization of the ctpA gene encoding a carboxy-terminal processing protease. Analysis of a spontanous photosystem II-deficient mutant strain of the cyanobacterium Synechocystis sp. PCC 6803
J. Biol. Chem.
269
19354-19359
1994
Synechocystis sp.
Inagaki, N.; Yamamoto, Y.; Mori, H.; Satoh, K.
Carboxy-terminal processing protease for the D1 precursor protein: cloning and sequencing of the spinach cDNA
Plant Mol. Biol.
30
39-50
1996
Spinacia oleracea
Inagaki, N.; Maitra, R.; Satoh, K.; Pakrasi, H.B.
Amino acid residues that are critical for in vivo catalytic activity of CtpA, the carboxyl-terminus processing protease for the D1 protein of photosystem II
J. Biol. Chem.
276
30099-30105
2001
Synechocystis sp.
Yamamoto, Y.; Inagaki, N.; Satoh, K.
Overexpression and characterization of carboxyl-terminal processing protease for precursor D1 protein: regulation of enzyme-substrate interaction by molecular environments
J. Biol. Chem.
276
7518-7525
2001
Spinacia oleracea
Trost, J.T.; Chisholm, D.A.; Jordan, D.B.; Diner, B.A.
The D1 C-terminal processing protease of photosystem II from Scenedesmus obliquus. Protein purification and gene characterization in wild type and processing mutants
J. Biol. Chem.
272
20348-20356
1997
Tetradesmus obliquus
Bowyeer, J.R.; Packer, J.C.L.; McCormack, B.A.; Whitelegge, J.P.; Robinson, C.; Taylor, M.A.
Carboxyl-terminal processing of the D1 protein and photoactivation of water-splitting photosystem II. Partial purification and characterization of the processing enzyme from Scendesmus obliquus and Pisum sativum
J. Biol. Chem.
267
5424-5433
1992
Pisum sativum, Tetradesmus obliquus
Yamamoto, Y.; Satoh, K.
Competitive inhibition analysis of the enzyme-substrate interaction in the carboxy-terminal processing of the precursor D1 protein of photosystem II reaction center using substituted oligopeptides
FEBS Lett.
430
261-265
1998
Spinacia oleracea
Taguchi, F.; Yamamoto, Y.; Satoh, K.
Recognition of the structure around the site of cleavage by the carboxyl-terminal processing protease for D1 precursor protein of the photosystem II reaction center
J. Biol. Chem.
270
10711-10716
1995
Spinacia oleracea
Chaal, B.K.; Mould, R.M.; Barbrook, A.C.; Grays, J.C.; Howe, C.J.
Characterization of a cDNA encoding the thylakoid processing peptidase from Arabidopsis thaliana. Implications for the origin and catalytic mechanism of the enzyme
J. Biol. Chem.
273
689-692
1998
Arabidopsis thaliana
Spetea, C.; Hundal, T.; Lohmann, F.; Andersson, B.
GTP bound to chloroplast thylakoid membranes is required for light-induced, multienzyme degradation of the photosystem II D1 protein
Proc. Natl. Acad. Sci. USA
96
6547-6552
1999
Spinacia oleracea
Kanervo, E.; Spetea, C.; Nishiyama, Y.; Murata, N.; Andersson, B.; Aro, E.M.
Dissecting a cyanobacterial proteolytic system: efficiency in inducing degradation of the D1 protein of photosystem II in cyanobacteria and plants
Biochim. Biophys. Acta
1607
131-140
2003
Synechocystis sp.
Spetea, C.; Keren, N.; Hundal, T.; Doan, J.M.; Ohad, I.; Andersson, B.
GTP enhances the degradation of the photosystem II D1 protein irrespective of its conformational heterogeneity at the Q(B) site
J. Biol. Chem.
275
7205-7211
2000
Pisum sativum, Spinacia oleracea
Richter, S.; Lamppa, G.K.
Structural properties of the chloroplast stromal processing peptidase required for its function in transit peptide removal
J. Biol. Chem.
278
39497-39502
2003
Pisum sativum (Q40983)
Chaal, B.K.; Ishida, K.i.; Green, B.R.
A thylakoidal processing peptidase from the heterokont alga Heterosigma akashiwo
Plant Mol. Biol.
52
463-472
2003
Heterosigma akashiwo
Ivleva, N.B.; Shestakov, S.V.; Pakrasi, H.B.
The carboxyl-terminal extension of the precursor D1 protein of photosystem II is required for optimal photosynthetic performance of the cyanobacterium Synechocystis sp. PCC 6803
Plant Physiol.
124
1403-1412
2000
Synechocystis sp.
Bandara, A.B.; Sriranganathan, N.; Schurig, G.G.; Boyle, S.M.
Carboxyl-terminal protease regulates Brucella suis morphology in culture and persistence in macrophages and mice
J. Bacteriol.
187
5767-5775
2005
Brucella suis bv. 1 (A0A0H3G8P9)
Tadokoro, A.; Hayashi, H.; Kishimoto, T.; Makino, Y.; Fujisaki, S.; Nishimura, Y.
Interaction of the Escherichia coli lipoprotein NlpI with periplasmic Prc (Tsp) protease
J. Biochem.
135
185-191
2004
Escherichia coli
Reiling, S.A.; Jansen, J.A.; Henley, B.J.; Singh, S.; Chattin, C.; Chandler, M.; Rowen, D.W.
Prc protease promotes mucoidy in mucA mutants of Pseudomonas aeruginosa
Microbiology
151
2251-2261
2005
Pseudomonas aeruginosa
Fabbri, B.J.; Duff, S.M.G.; Remsen, E.E.; Chen, Y.C.S.; Anderson, J.C.; CaJacob, C.A.
The carboxyterminal processing protease of D1 protein: Expression, purification and enzymology of the recombinant and native spinach proteins
Pest Manag. Sci.
61
682-690
2005
Spinacia oleracea (Q41376), Spinacia oleracea
Richter, S.; Zhong, R.; Lamppa, G.
Function of the stromal processing peptidase in the chloroplast import pathway
Physiol. Plant.
123
362-368
2005
Anabaena sp., Synechocystis sp., Chlamydomonas reinhardtii, Lotus japonicus, Medicago truncatula, Oryza sativa, Arabidopsis thaliana (O48870), Pisum sativum (Q40983), Plasmodium falciparum (Q8MVZ1)
-
Gilbert, K.B.; Vanderlinde, E.M.; Yost, C.K.
Mutagenesis of the carboxy terminal protease CtpA decreases desiccation tolerance in Rhizobium leguminosarum
FEMS Microbiol. Lett.
272
65-74
2007
Rhizobium leguminosarum
Duff, S.M.; Chen, Y.S.; Fabbri, B.J.; Yalamanchili, G.; Hamper, B.C.; Walker, D.M.; Brookfield, F.A.; Boyd, E.A.; Ashton, M.R.; Yarnold, C.J.; CaJacob, C.A.
The carboxyterminal processing protease of D1 protein: herbicidal activity of novel inhibitors of the recombinant and native spinach enzymes
Pestic. Biochem. Physiol.
88
1-13
2007
Spinacia oleracea
-
Booij-James, I.S.; Edelman, M.; Mattoo, A.K.
Nitric oxide donor-mediated inhibition of phosphorylation shows that light-mediated degradation of photosystem II D1 protein and phosphorylation are not tightly linked
Planta
229
1347-1352
2009
Landoltia punctata
Hoge, R.; Laschinski, M.; Jaeger, K.E.; Wilhelm, S.; Rosenau, F.
The subcellular localization of a C-terminal processing protease in Pseudomonas aeruginosa
FEMS Microbiol. Lett.
316
23-30
2011
Pseudomonas aeruginosa
Zhang, W.; Li, H.; Li, W.; Yang, Y.; Feng, L.; Liu, Y.; Qi, C.
Screening for inhibitors of plant protease D1 using novel monoclonal antibodies directed against its carboxyl terminal
Hybridoma
30
223-227
2011
Spinacia oleracea
Yue, R.; Wang, X.; Chen, J.; Ma, X.; Zhang, H.; Mao, C.; Wu, P.
A rice stromal processing peptidase regulates chloroplast and root development
Plant Cell Physiol.
51
475-485
2010
Oryza sativa Indica Group
Zou, C.G.; Xu, Y.F.; Liu, W.J.; Zhou, W.; Tao, N.; Tu, H.H.; Huang, X.W.; Yang, J.K.; Zhang, K.Q.
Expression of a serine protease gene prC is up-regulated by oxidative stress in the fungus Clonostachys rosea: implications for fungal survival
PLoS ONE
5
e13386
2010
Clonostachys rosea, Clonostachys rosea 611
Yokono, M.; Tomo, T.; Nagao, R.; Ito, H.; Tanaka, A.; Akimoto, S.
Alterations in photosynthetic pigments and amino acid composition of D1 protein change energy distribution in photosystem II
Biochim. Biophys. Acta
1817
754-759
2012
Synechocystis sp. (Q55669), Synechocystis sp.
Mastny, M.; Heuck, A.; Kurzbauer, R.; Heiduk, A.; Boisguerin, P.; Volkmer, R.; Ehrmann, M.; Rodrigues, C.D.; Rudner, D.Z.; Clausen, T.
CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis
Cell
155
647-658
2013
Bacillus subtilis (O35002)
Hernandez, S.B.; Ayala, J.A.; Rico-Perez, G.; Garcia-del Portillo, F.; Casadesus, J.
Increased bile resistance in Salmonella enterica mutants lacking Prc periplasmic protease
Int. Microbiol.
16
87-92
2013
Salmonella enterica, Salmonella enterica SL1344
Sugiura, M.; Ogami, S.; Kusumi, M.; Un, S.; Rappaport, F.; Boussac, A.
Environment of TyrZ in photosystem II from Thermosynechococcus elongatus in which PsbA2 is the D1 protein
J. Biol. Chem.
287
13336-13347
2012
Thermosynechococcus vestitus (P0A446)
Wegener, K.M.; Nagarajan, A.; Pakrasi, H.B.
An atypical psbA gene encodes a sentinel D1 protein to form a physiologically relevant inactive photosystem II complex in cyanobacteria
J. Biol. Chem.
290
3764-3774
2015
Crocosphaera subtropica ATCC 51142 (B1WZS6)
Carroll, R.; Rivera, F.; Cavaco, C.; Johnson, G.; Martin, D.; Shaw, L.
The lone S41 family C-terminal processing protease in Staphylococcus aureus is localized to the cell wall and contributes to virulence
Microbiology
160
1737-1748
2014
Staphylococcus aureus
Deng, C.Y.; Deng, A.H.; Sun, S.T.; Wang, L.; Wu, J.; Wu, Y.; Chen, X.Y.; Fang, R.X.; Wen, T.Y.; Qian, W.
The periplasmic PDZ domain-containing protein Prc modulates full virulence, envelops stress responses, and directly interacts with dipeptidyl peptidase of Xanthomonas oryzae pv. oryzae
Mol. Plant Microbe Interact.
27
101-112
2014
Xanthomonas oryzae pv. oryzae
Che, Y.; Fu, A.; Hou, X.; McDonald, K.; Buchanan, B.B.; Huang, W.; Luan, S.
C-terminal processing of reaction center protein D1 is essential for the function and assembly of photosystem II in Arabidopsis
Proc. Natl. Acad. Sci. USA
110
16247-16252
2013
Arabidopsis thaliana (O23614)
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