3.4.21.102: C-terminal processing peptidase

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For detailed information about C-terminal processing peptidase, go to the full flat file.

Word Map on EC 3.4.21.102

3.4.21.102

krabbe

thylakoids

leukodystrophy

globoid

twitcher

psychosine

galactosylceramide

photoinhibition

oxygen-evolving

galactocerebroside

agriculture

drug development

Reaction

the enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala-/-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. In the plant chloroplast, the enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II =

Synonyms

At4g17740, C-terminal processing peptidase, C-terminal processing protease, C-terminal protease, carboxy terminal-processing proteinase, carboxyl terminal processing protease of D1 protein, carboxyl-terminal processing protease, carboxyl-terminal protease, carboxyl-terminal-processing peptidase 2, carboxyterminal processing protease, carboxyterminal processing protease of D1 protein, chloroplast processing enzyme, chloroplast protein precursor processing proteinase, CPE, CtpA, CtpA gene product, CtpB, D1 preprotein-processing proteinase, D1 protein-processing enzyme, D1P, More, PA5734, photosystem D1 protein precursor carboxyl-terminal processing protease, photosystem II D1 C-terminal processing protease, photosystem II D1 protein, photosystem II D1 protein processing proteinase, photosystem II protein D1, photosystem II protein D1 2, PrC, Prc protease, PRC protein, processing peptidase, protease Re, proteinase CtpA, proteinase, chloroplast protein precursor-processing, PsbA4, PXO_04290, SPP, stromal processing peptidase, tail-specific protease, thylakoid protein precursor processing peptidase, Tsp protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.102 C-terminal processing peptidase

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Results	in table
6	Activating Compound
6231	AA Sequence
3	Application
2	CAS Registry Number
19	Cloned(Commentary)
3	Crystallization (Commentary)
6	Expression
13	General Information
1	General Stability
1	IC50 Value
11	Inhibitors
7	KM Value [mM]
34	Localization
12	Metals/Ions
17	Molecular Weight [Da]
42	Natural Substrates/ Products (Substrates)
60	Organism
20	PDB ID
5	pH Optimum
2	Posttranslational Modification
47	Protein Variants
12	Purification (Commentary)
13	Reaction
1	Reaction Type
59	Reference
1	Renatured (Commentary)
9	Source Tissue
3	Specific Activity [micromol/min/mg]
2	Storage Stability
100	Substrates and Products (Substrate)
14	Subunits
84	Synonyms
2	Temperature Optimum [°C]
3	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.21.102 - C-terminal processing peptidase

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0.0044 - 0.0111

2N-[[(1-sulfono-5-naphthyl)amino]ethyl]aminosuccinyl-Ala-Ala-Arg-Ala-Ala-[Nepsilon-[4-[4-(dimethylamino)phenylazo]benzoyl]lysyl]-(6-aminocaproyl)2-Glu-Asn-Tyr-Ala-Leu-Ala-Ala

3 entries

0.035

Ac-WARAAARAAARBAAB

Escherichia coli

137241

0.05

Arc repressor

Escherichia coli

137241

0.3

C-terminal 19 amino acids of preD1 protein

Spinacia oleracea

pH 7.7, 25°C

137247

additional information

2 entries