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3.4.21.10: acrosin

This is an abbreviated version!
For detailed information about acrosin, go to the full flat file.

Word Map on EC 3.4.21.10

Reaction

preferential cleavage: Arg-/-, Lys-/- =

Synonyms

53 kDa fucose-binding protein, acrosin, acrosin amidase, acrosin I, acrosin II, acrosomal protease, acrosomal proteinase, acrozonase, alpha-acrosin, beta-acrosin, proteinase, acrosomal, psi-acrosin, sperm acrosin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.10 acrosin

Activating Compound

Activating Compound on EC 3.4.21.10 - acrosin

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-methylarachidonoyl-2'-fluoro-ethylamide
-
i.e. MET-F-AEA, significantly increases at 10 nM, whereas higher MET-F-AEA levels do not induce the enzymatic activity.10 nM MET-F-AEA combined with 0.001 mM selective CB1-receptor antagonist SR141716 significantly increases the acrosin activity, while 0.001 mM CB2-receptor antagonist, SR144528 plus 10 nM MET-F-AEA and 0.001 mM capsazapine plus 10 nM METF-AEA have a similar behavior to that observed by using 10 nM MET-F-AEA alone
lysophosphatidylcholine
-
in heparin-capacitated spermatozoa, the addition of lysophosphatidylcholine produces a significant increase (about 7fold) in acrosin activity
progesterone
-
up to 2fold activation
additional information
-