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3.4.21.1: chymotrypsin

This is an abbreviated version!
For detailed information about chymotrypsin, go to the full flat file.

Word Map on EC 3.4.21.1

Reaction

Preferential cleavage: Tyr-/-, Trp-/-, Phe-/-, Leu-/- =

Synonyms

4CHA, Alcalase, alpha chymar, alpha chymotrypsin, alpha-Chy, alpha-chymar ophth, alpha-chymotrypsin, alpha-chymotrypsin A, alpha-CT, avazyme, bovine alpha-chymotrypsin, caldecrin, cationic chymotrypsin, cellulomonadin, CHT, Chtp, Chtr1, Chtr2, Chtr3, Chtr4, ChTRP, CHY1, CHY20, chymar, chymotest, chymotrypsin, chymotrypsin A, chymotrypsin B, chymotrypsin C, chymotrypsin C1, chymotrypsin I, chymotrypsin II, chymotrypsin isoform Kh1, chymotrypsin isoform Kh2, chymotrypsin isoform Kh3, chymotrypsin-B, CTRA, Ctrb, EC 3.4.4.5, EC 3.4.4.6, enzeon, LBCP, lysosomal Bid cleavage protease, PEG-alpha-chymotrypsin, PEG-modified alpha-chymotrypsin, quimar, quimotrase, serine protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.1 chymotrypsin

IC50 Value

IC50 Value on EC 3.4.21.1 - chymotrypsin

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.025
(methanethiolato)[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium (V)
Homo sapiens
-
above 0.025 mM
0.025
(p-methoxyphenylthiolato-S)[2,6-bis[(mercapto-kappaS)methyl]pyridine-kappaN] oxorhenium(V)
Homo sapiens
-
above 0.025 mM
0.0235
2-(2,6-difluorophenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0263
2-(2,6-dimethoxyphenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0188
2-(2-bromophenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0065
2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0099
2-(2-methoxyphenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0288
2-(2-methylphenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0238
2-(2-nitrophenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0121
2-(2-thienyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0418
2-(3-chlorophenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0282
2-(3-fluorophenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0239
2-(3-methylphenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0941
2-(3-methylphenyl)-7-nitro-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.314
2-(3-nitrophenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.159
2-(4-fluorophenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0144
2-(4-methoxyphenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0201
2-(4-methylphenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.0117
2-phenyl-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.329
7-chloro-2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-one
Bos taurus
pH 7.6, 30°C
0.008
Acacia confusa chymotrypsin inhibitor
Homo sapiens
-
-
-
0.025
aceto[2,6-bis[(butylthio-jS)methyl]phenyl-kappaC]-,(SP-4-3)-palladium(II)
Homo sapiens
-
above 0.025 mM
0.025
chloro[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium(V)
Homo sapiens
-
above 0.025 mM
0.0058
chymostatin
Bos taurus
pH 7.6, 30°C
0.0031
cyanopeptolin 1020
Bos taurus
pH 7.5, 37°C
0.00026
cyanopeptolin 1027
Bos taurus
pH 7.5, 37°C
0.0038
cyanopeptolin 978
Bos taurus
pH 7.5, 37°C
0.00026
cyanopeptolin 985
Bos taurus
pH 7.5, 37°C
0.0035
cyanopeptolin 992
Bos taurus
pH 7.5, 37°C
0.00007
MG-132
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.0136
N-(2-acetylphenyl)-N'-(3-methylphenyl) urea
Bos taurus
pH 7.6, 25°C
0.00824
N-(2-methylphenyl)-2-oxo-1-pyrrolidine carboxamide
Bos taurus
pH 7.6, 25°C
0.00084
N-(tert-butoxycarbonyl)-L-alanyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.00428
N-(tert-butoxycarbonyl)-L-alanyl-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.0015
N-(tert-butoxycarbonyl)-L-leucyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.00147
N-(tert-butoxycarbonyl)-L-phenylalanyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.00054
N-(tert-butoxycarbonyl)glycyl-N1-benzyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-L-glutamamide
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.00028
N-(tert-butoxycarbonyl)glycyl-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.00274
N-(tert-butoxycarbonyl)glycyl-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.00038
N-benzoyl-L-tyrosine ethyl ester
Homo sapiens
-
-
0.00451
N2-(tert-butoxycarbonyl)-N4-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-aspartamide
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.01
N2-(tert-butoxycarbonyl)-N5-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N1-(naphthalen-2-ylmethyl)-L-glutamamide
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.00412
N2-(tert-butoxycarbonyl)-N6-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N-(naphthalen-2-ylmethyl)-6-oxo-L-lysinamide
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.00002
PS-341
Homo sapiens
-
at 37°C for 1 h, in 20 mM Tris buffer, pH 8.0, 0.5 mM EDTA and 0.035% SDS
0.0148
trypsin-inhibitor
Bos taurus
-
-
-