3.4.21.1: chymotrypsin

This is an abbreviated version!
For detailed information about chymotrypsin, go to the full flat file.

Reaction

Preferential cleavage: Tyr-/-, Trp-/-, Phe-/-, Leu-/- =

Synonyms

4CHA, Alcalase, alpha chymar, alpha chymotrypsin, alpha-Chy, alpha-chymar ophth, alpha-chymotrypsin, alpha-chymotrypsin A, alpha-CT, avazyme, bovine alpha-chymotrypsin, caldecrin, cationic chymotrypsin, cellulomonadin, CHT, Chtp, Chtr1, Chtr2, Chtr3, Chtr4, ChTRP, CHY1, CHY20, chymar, chymotest, chymotrypsin, chymotrypsin A, chymotrypsin B, chymotrypsin C, chymotrypsin C1, chymotrypsin I, chymotrypsin II, chymotrypsin isoform Kh1, chymotrypsin isoform Kh2, chymotrypsin isoform Kh3, chymotrypsin-B, CTRA, Ctrb, EC 3.4.4.5, EC 3.4.4.6, enzeon, LBCP, lysosomal Bid cleavage protease, PEG-alpha-chymotrypsin, PEG-modified alpha-chymotrypsin, quimar, quimotrase, serine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.1 chymotrypsin

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Results	in table
24	Activating Compound
103	AA Sequence
19	Application
1	CAS Registry Number
7	Cloned(Commentary)
14	Crystallization (Commentary)
1998	Disease/ Diagnostics
5	General Information
11	General Stability
45	IC50 Value
335	Inhibitors
44	kcat/KM [mM/s]
115	Ki Value [mM]
189	KM Value [mM]
5	Localization
11	Metals/Ions
35	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
14	Organic Solvent Stability
199	Organism
245	PDB ID
31	pH Optimum
16	pH Range
17	pH Stability
10	pI Value
8	Posttranslational Modification
5	Protein Variants
32	Purification (Commentary)
2	Reaction
1	Reaction Type
172	Reference
113	Source Tissue
33	Specific Activity [micromol/min/mg]
6	Storage Stability
250	Substrates and Products (Substrate)
19	Subunits
148	Synonyms
16	Temperature Optimum [°C]
11	Temperature Range [°C]
27	Temperature Stability [°C]
187	Turnover Number [1/s]

General Information

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General Information on EC 3.4.21.1 - chymotrypsin

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Mus musculus

-

chymotrypsinogen B1-deficient mice given cerulein have significant increases in intrapancreatic trypsin activity and develop more severe pancreatitis compared with control mice

753722

metabolism

Mus musculus

-

intrapancreatic activation of the digestive proteases trypsin and chymotrypsin is an early event in the development of pancreatitis

753722

physiological function

3 entries

physiological function

Carassius auratus

-

anti-chymotrypsin B weakly cross reacts with chymotrypsin A

708555

physiological function

Homo sapiens

-

intracellular delivery of chymotrypsin significantly potentiates apoptosis, and chymotrypsin is involved in mitochondrial fission during apoptosis. Chymotrypsin cleaves calcineurin into a 47-kDa fragment and a 13-kDa fragment, the cleavage activates the phosphatase activity of calcineurin in a Ca2+/CaM-independent manner. Cleaved calcineurin induces the translocation of cytosolic Drp1 to the mitochondria and triggers significant mitochondrial fission

732856

physiological function

Mus musculus

-

chymotrypsinogen B1 protects against secretagogue-induced pancreatitis by reducing trypsin activity

753722