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3.4.19.7: N-Formylmethionyl-peptidase

This is an abbreviated version!
For detailed information about N-Formylmethionyl-peptidase, go to the full flat file.

Reaction

release of an N-terminal, formyl-methionyl residue from a polypeptide =

Synonyms

(fMet)-releasing enzyme, Aminopeptidase, formylmethionine, Formylmethionine aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.7 N-Formylmethionyl-peptidase

Substrates Products

Substrates Products on EC 3.4.19.7 - N-Formylmethionyl-peptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Acetyl-Met-Leu + H2O
?
show the reaction diagram
-
-
-
-
?
Acetyl-Met-Leu-Phe + H2O
?
show the reaction diagram
-
-
-
-
?
Formylnorleucine-Leu-Phe + H2O
?
show the reaction diagram
-
-
-
-
?
N-Formyl-Met 2-naphthylamide + H2O
N-Formyl-Met + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
N-Formyl-Met-Leu + H2O
N-Formyl-Met + Leu
show the reaction diagram
-
-
-
-
?
N-Formyl-Met-Leu-Phe + H2O
N-Formyl-Met + Leu-Phe
show the reaction diagram
-
-
-
?
N-Formyl-Met-Leu-Tyr + H2O
N-Formyl-Met + Leu-Tyr
show the reaction diagram
-
-
-
?
N-Formyl-Met-Phe + H2O
N-Formyl-Met + Phe
show the reaction diagram
-
-
-
?
N-Formyl-Met-Trp + H2O
N-Formyl-Met + Trp
show the reaction diagram
-
-
-
?
N-Formyl-Met-Val + H2O
N-Formyl-Met + Val
show the reaction diagram
-
-
-
?
N-Formylmethionyl oligopeptides + H2O
?
show the reaction diagram
-
the presence of this enzyme in intestinal mucosa can prevent absorption of intact bioactive potent inflammatory N-formylmethionyl oligopeptides produced by commensal bacteria in the gut lumen
-
-
?
Natural formylmethionine oligopeptide from E. coli culture supernatants + H2O
?
show the reaction diagram
-
loss of bioactivity and immuno-reactivity
-
-
?
additional information
?
-
-
highly specific for N-formyl-Met peptides, will not cleave methionyl peptides or N-formyl derivatives of amino acids other than methionine
-
-
?