3.4.19.13: glutathione gamma-glutamate hydrolase
This is an abbreviated version!
For detailed information about glutathione gamma-glutamate hydrolase, go to the full flat file.
Word Map on EC 3.4.19.13
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3.4.19.13
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medicine
-
hydroxyacyl
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halide
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alpha-globin
-
formyl
-
dihalomethanes
-
methanes
-
phosphoglycolate
-
monoxide
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decomposes
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diverted
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halogenated
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formaldehyde
- 3.4.19.13
- medicine
-
hydroxyacyl
- halide
-
alpha-globin
-
formyl
-
dihalomethanes
- methanes
- phosphoglycolate
-
monoxide
-
decomposes
-
diverted
-
halogenated
- formaldehyde
Reaction
Synonyms
At4g29210, BaGGT42, BaGGT469, BlGGT13, BsGGT168, gamma-glutamyl transpeptidase, gamma-glutamyl-transpeptidase, gamma-GT, GGT, GGT-1, GGT1, GGT3, GGT4, GGT5, hp1118, More
ECTree
3.4.19.13 glutathione gamma-glutamate hydrolaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.19.13 - glutathione gamma-glutamate hydrolase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S,S)-gamma-glutamyl-(cis-S-1-propenyl)-thioglycine + H2O
(S)-(cis-S-1-propenyl)thioglycine + L-glutamate
-
-
-
-
?
glutathione S-bimane + H2O
L-cysteinylglycyl S-bimane + L-glutamate
-
-
-
?
glutathione-S-monobromobimane conjugate + H2O
L-cysteinylglycine-S-monobrombimane conjugate + L-glutamate
-
-
-
?
reduced glutathione + H2O
L-cysteinylglycine + L-glutamate
-
-
-
?
S-(2-(4-chlorophenoxy)-2-methylpropanoyl)glutathione + H2O
S-(2-(4-chlorophenoxy)-2-methylpropanoyl)-L-cysteinylglycine + L-glutamate
-
i.e. clofibril-S-acylglutathione
the first step in the degradation of clofibril S-acylglutathione. complete degradation with formation of clofibryl-S-acyl-N-acetylcysteine and its disulfide, with no detection of clofibryl-S-acyl-cysteinylglycine thioester
-
?
S-(4-nitro-benzyl)glutathione + H2O
S-(4-nitro-benzyl)-L-cysteinylglycine + L-glutamate
-
-
-
?
S-(5-hydroxy-2-pentyltetrahydrofuran-3-yl)glutathione + H2O
S-(5-hydroxy-2-pentyltetrahydrofuran-3-yl)-L-cysteinylglycine + L-glutamate
-
-
the GGT-dependent metabolism of S-(5-hydroxy-2-pentyltetrahydrofuran-3-yl)glutathione in the V79 GGT cell line is associated with a considerable increase of cytotoxicity. The cytotoxic effect is dose- and time-dependent, with 100% cellular death at 200 mM S-(5-hydroxy-2-pentyltetrahydrofuran-3-yl)glutathione after 24 h incubation in V79 GGT cells
-
?
S-linked bis-GSH conjugate of 1,6-hexamethylene diisocyanate + H2O
bis(Cys-Gly)-1,6-hexamethylene diisocyanate + 2 L-glutamate
-
-
-
?
S-linked bis-GSH conjugate of 4,4'-methylene diphenyl diisocyanate + H2O
bis(Cys-Gly)-4,4'-methylene diphenyl diisocyanate + 2 L-glutamate
-
-
-
?
S-linked mono-GSH conjugate of 1,6-hexamethylene diisocyanate + H2O
(Cys-Gly)-1,6-hexamethylene diisocyanate + L-glutamate
-
-
-
?
S-linked mono-GSH conjugate of 4,4'-methylene diphenyl diisocyanate + H2O
(Cys-Gly)-4,4'-methylene diphenyl diisocyanate + L-glutamate
-
-
-
?
S-methylglutathione + H2O
S-methyl-L-cysteinylglycine + L-glutamate
-
-
-
?
7-(gamma-L-glutamylamino)-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-glutamate
-
-
-
-
?
7-(gamma-L-glutamylamino)-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + L-glutamate
-
-
-
-
?
diclofenac-S-acyl-glutathione + H2O
diclofenac-S-acyl-L-cysteinylglycine + L-glutamate
-
-
-
-
?
diclofenac-S-acyl-glutathione + H2O
diclofenac-S-acyl-L-cysteinylglycine + L-glutamate
-
-
-
-
?
gamma-glutamyl-p-nitroanilide + H2O
L-glutamate + p-nitroaniline
-
the enzyme has low hydrolase activity and high gamma-glutamyl transpeptidase activity
-
-
?
gamma-glutamyl-p-nitroanilide + H2O
L-glutamate + p-nitroaniline
hydrolytic activity
-
-
?
glutathione + H2O
L-cysteinylglycine + L-glutamate
-
the reaction consists of two steps. First the active O atom of Thr391 attacks the carbonyl carbon atom of the gamma-glutamyl compound to form the gamma-glutamyl-enzyme intermediate, and then the gamma-glutamyl moiety is transferred to another substrate, i.e. reaction of EC 2.3.2.2, or the gamma-glutamyl-enzyme bond is hydrolyzed to reform the resting enzyme. The second step of the reaction, the hydrolysis of the intermediate, is much slower than the first reaction step
-
?
L-gamma-glutamyl-4-nitroanilide + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-gamma-glutamyl-4-nitroanilide + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-gamma-glutamyl-4-nitroanilide + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-gamma-glutamyl-4-nitroanilide + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-gamma-glutamyl-4-nitroanilide + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-gamma-glutamyl-4-nitroanilide + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-gamma-glutamyl-4-nitroanilide + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-glutamic acid 4-nitroanilide + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-glutamic acid 4-nitroanilide + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-glutamic acid-(4-nitroanilide) + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-glutamic acid-(4-nitroanilide) + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-glutamic acid-(4-nitroanilide) + H2O
4-nitroaniline + L-glutamate
-
-
-
?
L-glutamic acid-(4-nitroanilide) + H2O
4-nitroaniline + L-glutamate
-
-
-
?
additional information
?
-
the enzyme also shows transpeptidase activity
-
-
?
additional information
?
-
the enzyme also shows transpeptidase activity
-
-
?
additional information
?
-
-
the enzyme also shows transpeptidase activity
-
-
?
additional information
?
-
residue Thr391, the N-terminal residue of the small subunit, is the nucleophile for the enzymatic reaction
-
-
?
additional information
?
-
protein additionally has EC 2.3.2.2, gamma-glutamyltransferase activity
-
-
?
additional information
?
-
protein additionally has EC 2.3.2.2, gamma-glutamyltransferase activity
-
-
?
additional information
?
-
-
enzyme additionally catalyzes the reaction of EC 2.3.2.2, gamma-glutamyltransferase
-
-
?
