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3.4.19.1: acylaminoacyl-peptidase

This is an abbreviated version!
For detailed information about acylaminoacyl-peptidase, go to the full flat file.

Word Map on EC 3.4.19.1

Reaction

cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide =

Synonyms

AAP, AARE, AARE/OPH, AAREP, AcpH, acyl aminoacyl peptidase, acyl peptide hydrolase, Acyl-peptide hydrolase, acyl-peptide releasing enzyme, acylamino acid-releasing enzyme, acylamino acid-releasing enzyme/oxidized protein hydrolase, acylamino-acid-releasing enzyme, acylaminoacyl peptidase, Acylaminoacyl-peptidase, acylpeptide hydrolase, acylpeptide hydrolase/esterase, alpha-N-acylpeptide hydrolase, ApAAP, apAPH, APEH, APEH-1, apeH-2, APEH-3, APEH-3Ss, APEHs, APE_1547.1, APH, APHdr, AtAARE, BmAPH, cAARE, DNF15S2 protein, N-acylaminoacyl-peptide hydrolase, N-acylpeptide hydrolase, N-formylmethionine (fMet) aminopeptidase, OP85, PhAAP, pi-APH, PM hydrolase, PMH, SpAAP, sso2141, SSO2693, ST0779, yuxL

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.1 acylaminoacyl-peptidase

KM Value

KM Value on EC 3.4.19.1 - acylaminoacyl-peptidase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00129 - 0.0071
2-aminobenzoyl-Ala-Leu-Phe-Gln-Gly-Pro-Phe(NO2)-Ala
0.01
2-naphthyl butyrate
-
-
0.63
4-nitrophenyl acetate
-
-
0.06
4-nitrophenyl hexanoate
-
-
0.00913 - 1.76
Ac-Leu-p-nitroanilide
0.12 - 20.2
acetyl-Ala-4-nitroanilide
7.6 - 8.6
Acetyl-Ala-Ala
13 - 15.2
Acetyl-Ala-Ala-Ala-Ala
11 - 12.9
acetyl-Leu-4-nitroanilide
0.11
acetyl-Met-7-amido-4-methylcoumarin
50°C, pH 8
0.0082 - 0.1
acetyl-Phe-2-naphthylamide
0.39
Ala-beta-naphthylamide
-
-
1
butyryl thiocholine
-
-
1.7
formylmethionine-beta-naphthylamide
-
-
0.04
formylmethionine-Leu
-
-
0.18
formylmethionine-Leu-Phe
-
-
0.22
formylmethionine-Leu-Tyr
-
-
0.63
formylmethionine-Phe
-
-
0.71
formylmethionine-Trp
-
-
0.06
formylmethionine-Val
-
-
0.12
Leu-beta-naphthylamide
-
-
1.8 - 18.4
N-acetyl-Ala p-nitroanilide
0.616
N-acetyl-Ala-4-nitroanilide
-
-
0.8 - 7.6
N-acetyl-Ala-Ala
0.6
N-acetyl-Ala-Ala-Ala
-
-
0.8 - 13
N-acetyl-Ala-Ala-Ala-Ala
1.7
N-acetyl-Ala-Ala-Arg-Gly
-
-
2
N-acetyl-Ala-Ala-Phe-Gly
-
-
3.6
N-acetyl-Ala-Ala-Pro-Ala
-
-
0.006 - 4.6
N-acetyl-Ala-p-nitroanilide
0.8 - 0.83
N-acetyl-L-Ala-4-nitroanilide
0.8 - 11.4
N-acetyl-L-alanyl 4-nitroanilide
0.6
N-acetyl-L-Leu-4-nitroanilide
in 25 mM Tris-HCl buffer pH 7.5, at 90°C
0.3 - 0.6
N-acetyl-L-leucyl 4-nitroanilide
0.04
N-acetyl-L-Phe-4-nitroanilide
in 25 mM Tris-HCl buffer pH 7.5, at 90°C
4
N-acetyl-L-phenylalanyl 4-nitroanilide
pH 7.5, 90°C
11
N-acetyl-Leu p-nitroanilide
-
-
0.4 - 10.5
N-acetyl-Leu-p-nitroanilide
0.49 - 0.68
N-acetyl-Met-Ala
0.02
N-acetyl-Met-Leu
-
-
0.16
N-acetyl-Met-Leu-Phe
-
-
0.00566 - 0.1
N-acetyl-Phe-2-naphthylamide
35.7 - 114.6
p-nitrophenyl caprylate
0.02
p-nitrophenylbutyrate
-
-
0.16
p-nitrophenylpropionate
-
-
0.07
p-nitrophenylvalerate
-
-
0.028
Phe-beta-naphthylamide
-
-
0.013
Pro-beta-naphthylamide
-
-
1.91
puromycin
-
-
0.067
Tyr-beta-naphthylamide
-
-
additional information
additional information
thermodynamics
-