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3.4.19.1: acylaminoacyl-peptidase

This is an abbreviated version!
For detailed information about acylaminoacyl-peptidase, go to the full flat file.

Word Map on EC 3.4.19.1

Reaction

cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide =

Synonyms

AAP, AARE, AARE/OPH, AAREP, AcpH, acyl aminoacyl peptidase, acyl peptide hydrolase, Acyl-peptide hydrolase, acyl-peptide releasing enzyme, acylamino acid-releasing enzyme, acylamino acid-releasing enzyme/oxidized protein hydrolase, acylamino-acid-releasing enzyme, acylaminoacyl peptidase, Acylaminoacyl-peptidase, acylpeptide hydrolase, acylpeptide hydrolase/esterase, alpha-N-acylpeptide hydrolase, ApAAP, apAPH, APEH, APEH-1, apeH-2, APEH-3, APEH-3Ss, APEHs, APE_1547.1, APH, APHdr, AtAARE, BmAPH, cAARE, DNF15S2 protein, N-acylaminoacyl-peptide hydrolase, N-acylpeptide hydrolase, N-formylmethionine (fMet) aminopeptidase, OP85, PhAAP, pi-APH, PM hydrolase, PMH, SpAAP, sso2141, SSO2693, ST0779, yuxL

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.1 acylaminoacyl-peptidase

Inhibitors

Inhibitors on EC 3.4.19.1 - acylaminoacyl-peptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(10E,12Z)-octadeca-10,12-dienoic acid
-
non-competitive inhibition mechanism
1-butane boronic acid
-
-
1-ethyl-3,3'-dimethylaminopropylcarbodiimide
-
-
1-methylethyl dodecylphosphonofluoridoate
2-(octyloxy)-4H-1,3,2-benzodioxaphosphinine 2-oxide
2-(pentylsulfanyl)-4H-1,3,2-benzodioxaphosphinine 2-oxide
2-heptyl-4H-1,3,2-benzodioxaphosphinine 2-oxide
4-(2-aminoethyl) benzenesulfonyl fluoride
-
-
5,5'-dithiobis-(2-nitrobenzoate)
-
partial
Ac-Ala
-
competitive inhibitor
Ac-Gly-prolineboronic acid
-
-
Ac-Leu-CH2-Cl
-
irreversible inhibitor
Ac-Met
-
competitive inhibitor
Ac-Phe-OH
product-like inhibitor
acephate
-
IC50: 0.0062 mM
acetyl-Gly-prolineboronic acid
-
selectivity for APH 25fold higher than for fibroblast activation protein
Acetyl-Phe
activated-thiol-Sepharose
-
-
-
ampicillin
-
partial
benzyloxycarbonyl-Gly-Gly-Phe-chloromethyl ketone
CMK, chloromethyl ketone inhibitor, enzyme binding structure analysis, molecular dynamics studies, overview
bis(1-methylethyl) 4-nitrophenyl phosphate
-
IC50: 0.016 mM
bis(sulfosuccinimidyl)suberate
-
-
CaCl2
100 mM, 52% inhibition
carbodiimide/aminoalkyl-agarose
-
-
-
carbodiimide/dicarboxylic acid
-
-
-
chlorfenvinphos
-
IC50 at pH 7.4, 37°C: 1386 nM
chlorpyrifos
chlorpyrifos cyclohexyl
chlorpyrifos isopropyl
-
IC50: 0.0033 mM
chlorpyrifos methyl
chlorpyrifos n-butyl
-
IC50: 0.00006 mM
chlorpyrifos n-propyl
-
IC50: 0.00007 mM
chlorpyrifos-methyl oxon
-
IC50 at pH 7.4, 37°C: 18.3 nM
chlorpyrifosmethyl oxon
-
Cl-
-
activity towards N-acetyl-Ala-Ala and N-acetyl-Ala-Ala-Ala
CoCl2
-
1 mM, 21% inhibition
di(2-pyridyl)disulfide
-
-
diazoxon
dichlorvos
dicyclohexyl 2,2-dichloroethenyl phosphate
diethyl 4-methyl-3-nitrophenyl phosphate
-
IC50: 0.002 mM
diethyl dicarbonate
diisopropyl fluorophosphate
diisopropylfluorophosphate
dipentyl fluorophosphate
diphenylphosphinic fluoride
dithiothreitol
-
-
ebelactone A
-
-
EDTA
1 mM, 10% inhibition
epoxy-Sepharose
-
-
-
ethyl octylphosphonofluoridoate
FeCl2
-
1 mM, 21% inhibition
Glutaraldehyde
-
-
Gly methyl ester
-
-
Guanidine-HCl
1 M, complete loss of activity, after removal of guanidine-HCl the enzyme recovers 25% of its activity
guanidine/HCl
-
1 M, complete inactivation
heptyl ethylphosphonofluoridoate
iodoacetamide
iodoacetic acid
K+
1 mM, 4% inhibition
malaoxon
-
IC50 at pH 7.4, 37°C: 1400000 nM
malathion
significantly inhibits the activity of enzyme APH both in vitro and in vivo
Mipafox
-
IC50 at pH 7.4, 37°C: 3013 nM
N,N-Dimethylformamide
-
-
N-acetyl-Ala
N-acetyl-Ala chloromethyl ketone
-
inactivation follows first order kinetics, acetyl-Ala protects
N-acetyl-Leu chloromethyl ketone
-
-
N-acetyl-Met
N-acetyl-Val
-
-
N-ethyl-5-phenylisoxazolium 3'-sulfonate
-
i.e. Woodward's reagent
N-hydroxysuccinimide agarose
-
-
-
NaCl
-
1 mM, 78% loss of activity
naled
nonyl ethylphosphonofluoridoate
octane-1-sulfonyl fluoride
octyl methylphosphonofluoridoate
p-hydroxymercuribenzoate
-
-
p-nitrophenyl-N-propyl carbamate
-
potent active site-directed, pseudo-first-order kinetics
paraoxon
penicillin G
-
partial
pentyl ethylphosphonofluoridoate
peptide SsCEI 2
-
specific and efficient inhibition. No inhibition in presence of peptide SsCEI 3 and peptide SsCEI 4
-
phenylmethylsulfonyl fluoride
-
-
phosphatidylethanolamine-binding protein inhibitor SsCEI
-
phoxim
significantly inhibits the activity of enzyme APH both in vitro and in vivo
profenofos
-
IC50: 0.002 mM
SCN-
-
activity towards N-acetyl-Ala-Ala and N-acetyl-Ala-Ala-Ala
Sulfolobus solfataricus chymotrypsin-elastase inhibitor
specific inhibition
-
thimerosal
-
-
Trichlorfon
-
IC50: 0.018 mM
tridecyl methylphosphonofluoridoate
Triton X-100
1 mg/ml, 4% inhibition
Tween 20
1 mg/ml, 10% inhibition
Tween 80
1 mg/ml, 18% inhibition
additional information
-