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3.4.19.1: acylaminoacyl-peptidase

This is an abbreviated version!
For detailed information about acylaminoacyl-peptidase, go to the full flat file.

Word Map on EC 3.4.19.1

Reaction

cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide =

Synonyms

AAP, AARE, AARE/OPH, AAREP, AcpH, acyl aminoacyl peptidase, acyl peptide hydrolase, Acyl-peptide hydrolase, acyl-peptide releasing enzyme, acylamino acid-releasing enzyme, acylamino acid-releasing enzyme/oxidized protein hydrolase, acylamino-acid-releasing enzyme, acylaminoacyl peptidase, Acylaminoacyl-peptidase, acylpeptide hydrolase, acylpeptide hydrolase/esterase, alpha-N-acylpeptide hydrolase, ApAAP, apAPH, APEH, APEH-1, apeH-2, APEH-3, APEH-3Ss, APEHs, APE_1547.1, APH, APHdr, AtAARE, BmAPH, cAARE, DNF15S2 protein, N-acylaminoacyl-peptide hydrolase, N-acylpeptide hydrolase, N-formylmethionine (fMet) aminopeptidase, OP85, PhAAP, pi-APH, PM hydrolase, PMH, SpAAP, sso2141, SSO2693, ST0779, yuxL

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.1 acylaminoacyl-peptidase

IC50 Value

IC50 Value on EC 3.4.19.1 - acylaminoacyl-peptidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.08
(10E,12Z)-octadeca-10,12-dienoic acid
Saccharolobus solfataricus
-
pH 7.5, 37°C
0.00026 - 0.0015
1-methylethyl dodecylphosphonofluoridoate
0.00018 - 0.00023
2-(octyloxy)-4H-1,3,2-benzodioxaphosphinine 2-oxide
0.0011 - 0.0015
2-(pentylsulfanyl)-4H-1,3,2-benzodioxaphosphinine 2-oxide
0.0014 - 0.0016
2-heptyl-4H-1,3,2-benzodioxaphosphinine 2-oxide
0.0062
acephate
Homo sapiens
-
IC50: 0.0062 mM
0.016
bis(1-methylethyl) 4-nitrophenyl phosphate
Homo sapiens
-
IC50: 0.016 mM
0.001386
chlorfenvinphos
Sus scrofa
-
IC50 at pH 7.4, 37°C: 1386 nM
0.000021 - 0.000071
chlorpyrifos
0.00035 - 0.00086
chlorpyrifos cyclohexyl
0.0033
chlorpyrifos isopropyl
Homo sapiens
-
IC50: 0.0033 mM
0.00008 - 0.00031
chlorpyrifos methyl
0.00006
chlorpyrifos n-butyl
Homo sapiens
-
IC50: 0.00006 mM
0.00007
chlorpyrifos n-propyl
Homo sapiens
-
IC50: 0.00007 mM
0.0000183
chlorpyrifos-methyl oxon
Sus scrofa
-
IC50 at pH 7.4, 37°C: 18.3 nM
0.0000225
DFP
Sus scrofa
-
IC50 at pH 7.4, 37°C: 22.5 nM
0.00089 - 0.001386
diazoxon
0.0001186 - 0.00056
dichlorvos
0.0001 - 0.00025
dicyclohexyl 2,2-dichloroethenyl phosphate
0.002
diethyl 4-methyl-3-nitrophenyl phosphate
Homo sapiens
-
IC50: 0.002 mM
0.000011 - 0.000017
diisopropylfluorophosphate
0.0000099 - 0.000011
dipentyl fluorophosphate
0.00024 - 0.00041
diphenylphosphinic fluoride
0.00011 - 0.00021
ethyl octylphosphonofluoridoate
0.000027 - 0.00023
heptyl ethylphosphonofluoridoate
1.4
malaoxon
Sus scrofa
-
IC50 at pH 7.4, 37°C: 1400000 nM
0.003013
Mipafox
Sus scrofa
-
IC50 at pH 7.4, 37°C: 3013 nM
0.00037 - 0.00087
naled
0.000052 - 0.00028
nonyl ethylphosphonofluoridoate
0.067 - 0.073
octane-1-sulfonyl fluoride
0.000043 - 0.00016
octyl methylphosphonofluoridoate
0.003805 - 0.0047
paraoxon
0.00013 - 0.00027
pentyl ethylphosphonofluoridoate
0.01
peptide SsCEI 2
Saccharolobus solfataricus
-
pH 7.5, 37°C
-
0.00000002
phosphatidylethanolamine-binding protein inhibitor SsCEI
Saccharolobus solfataricus
pH 7.5, 80°C, substrate: N-acetyl-L-leucyl 4-nitroanilide
-
0.002
profenofos
Homo sapiens
-
IC50: 0.002 mM
0.018
Trichlorfon
Homo sapiens
-
IC50: 0.018 mM
0.00032 - 0.0048
tridecyl methylphosphonofluoridoate
additional information
additional information
-