3.4.17.8: muramoylpentapeptide carboxypeptidase

This is an abbreviated version!
For detailed information about muramoylpentapeptide carboxypeptidase, go to the full flat file.

Reaction

cleavage of the bond UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-6-carboxy-L-lysyl-D-alanyl-/-D-alanine =

Synonyms

carboxypeptidase D-alanyl-D-alanine, carboxypeptidase I, carboxypeptidase, muramoylpentapeptide, D-alanine carboxypeptidase, D-alanine carboxypeptidase I, D-alanine-D-alanine-carboxypeptidase, D-alanyl-D-alanine carboxypeptidase, D-alanyl-D-alanine peptidase, DacC, DD-Carboxypeptidase, DD-CPase, DD-peptidase, EC 3.4.12.6, Metallo DD-peptidase, msmeg_2432, msmeg_2433, PBP 5, PBP5, PdcA, penicillin binding protein 5, penicillin-binding protein 5, UDP-N-acetylmuramoyl-tetrapeptidyl-D-alanine alanine-hydrolase, VanX, VanXYc, VanY, Zn DD-peptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.17 Metallocarboxypeptidases

                3.4.17.8 muramoylpentapeptide carboxypeptidase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
25	AA Sequence
2	Application
1	CAS Registry Number
5	Cloned(Commentary)
5	Crystallization (Commentary)
1	Expression
2	General Information
39	Inhibitors
2	kcat/KM [mM/s]
7	Ki Value [mM]
14	KM Value [mM]
12	Localization
12	Metals/Ions
3	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
72	Organism
1	PDB ID
6	pH Optimum
1	pH Range
1	pI Value
22	Protein Variants
3	Purification (Commentary)
3	Reaction
1	Reaction Type
34	Reference
13	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
53	Substrates and Products (Substrate)
1	Subunits
44	Synonyms
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
4	Turnover Number [1/s]

Reference

topprint

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Reference on EC 3.4.17.8 - muramoylpentapeptide carboxypeptidase

Please use the Reference Search for a specific query.

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

28885

Joris, B.; van Beeumen, J.; Casagrande, F.; Gerday, C.; Frere, J.M.; Ghuysen, J.M.

The complete amino acid sequence of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of streptomyces albus G

Eur. J. Biochem.

130

53-69

1983

Streptomyces albus

6825689

brenda

28886

Dideberg, O.; Charlier, P.; Dive, G.; Joris, B.; Frere, J.M.; Ghuysen, J.M.

Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 A resolution

Nature

299

469-470

1982

Streptomyces albus

7121588

brenda

28887

Dideberg, O.; Joris, B.; Frere, J.M.; Ghuysen, J.M.; Weber, G.; Robaye, R.; Delbrouck, J.M.; Roelandts, I.

The exocellular DD-carboxypeptidase of Streptomyces albus G: a metallo (Zn2+) enzyme

FEBS Lett.

117

215-218

1980

Streptomyces albus

7409167

brenda

36286

DeCoen, J.L.; Lamotte-Brasseur, J.; Ghuysen, J.M.; Frere, J.M.; Perkins, H.R.

Conformational analysis of peptide substrates and inhibitors of the Zn2+ G and serine R61 D-alanyl-D-alanine peptidases

Eur. J. Biochem.

121

221-232

1981

Streptomyces albus

7035167

brenda

36304

Kimura, Y.; Takashima, Y.; Tokumasu, Y.; Sato, M.

Molecular cloning, sequence analysis, and characterization of a penicillin-resistant DD-carboxypeptidase of Myxococcus xanthus

J. Bacteriol.

181

4696-4699

1999

Myxococcus xanthus

10419975

brenda

36311

Kelly, J.A.; Kuzin, A.P.

The refined crystallographic structure of a DD-peptidase penicillin-target enzyme at 1.6 A resolution

J. Mol. Biol.

254

223-236

1995

Streptomyces sp., Streptomyces albus

7490745

brenda

36419

Labischinski, H.; Giesbrecht, P.; Fischer, E.; Barnickel, G.; Bradaczeck, H.; Frere, J.M.; Houssier, C.; Charlier, P.; Dideberg, O.; Ghuysen, J.M.

Study of the Zn-containing DD-carboxypeptidase of Streptomyces albus G by small-angle X-ray scattering in solution

Eur. J. Biochem.

138

83-87

1984

Streptomyces albus

6704204

brenda

36423

Dideberg, O.; Charlier, P.; Dupont, L.; Vermeire, M.; Frere, J.M.; Ghuysen, J.M.

The 4.5 A resolution structure analysis of the exocellular DD-carboxypeptidase of Streptomyces albus G

FEBS Lett.

117

212-214

1980

Streptomyces albus

7409166

brenda

36425

Ghuysen, J.M.; Leyh-Bouille, M.; Bonaly, R.; Nieto, M.; Perkins, H.R.; Schleifer, K.H.; Kandler, O.

Isolation of DD carboxypeptidase from Streptomyces albus G culture filtrates

Biochemistry

9

2955-2960

1970

Streptomyces albus

4919965

brenda

36426

Leyh-Bouille, M.; Ghuysen, J.M.; Nieto, M.; Perkins, H.R.; Schleifer, K.H.; Kandler, O.

On the Streptomyces albus G DD carboxypeptidase mechanism of action of penicillin, vancomycin, and ristocetin

Biochemistry

9

2971-2975

1970

Streptomyces albus

5474798

brenda

36427

Nieto, M.; Perkins, H.R.; Leyh-Bouille, M.; Frere, J.M.; Ghuysen, J.M.

Peptide inhibitors of Streptomyces DD-carboxypeptidases

Biochem. J.

131

163-171

1973

Streptomyces albus

4722034

brenda

36429

Umbreit, J.N.; Strominger, J.L.

D-Alanine carboxypeptidase from Bacillus subtilis membranes. I. Purification and characterization

J. Biol. Chem.

248

6759-6766

1973

Bacillus subtilis

4200864

brenda

36430

Diaz-Maurino, T.; Nieto, M.; Perkins, H.R.

Membrane-bound DD-carboxypeptidases from Bacillus megaterium KM

Biochem. J.

134

391-402

1974

Priestia megaterium, Priestia megaterium KM / ATCC 13632

-

brenda

668456

Podmore, A.H.B.; Reynolds, P.E.

Purification and characterization of VanXYc, a D,D-dipeptidase/D,D-carboxypeptidase in vancomycin-resisitant Enterococcus gallinarium BM4174

Eur. J. Biochem.

269

2740-2746

2002

Enterococcus gallinarum, Enterococcus gallinarum BM4174

12047383

brenda

669108

Severin, A.; Wu, S.W.; Tabei, K.; Tomasz, A.

High-level beta-lactam resistance and cell wall synthesis catalyzed by the mecA homologue of Staphylococcus sciuri introduced into Staphylococcus aureus

J. Bacteriol.

187

6651-6658

2005

Mammaliicoccus sciuri

16166526

brenda

683148

Adediran, S.A.; Kumar, I.; Pratt, R.F.

Deacylation transition states of a bacterial DD-peptidase

Biochemistry

45

13074-13082

2006

Streptomyces sp.

17059224

brenda

683151

Josephine, H.R.; Charlier, P.; Davies, C.; Nicholas, R.A.; Pratt, R.F.

Reactivity of penicillin-binding proteins with peptidoglycan-mimetic beta-lactams: whats wrong with these enzymes?

Biochemistry

45

15873-15883

2006

Escherichia coli

17176110

brenda

683158

Zhang, W.; Shi, Q.; Meroueh, S.O.; Vakulenko, S.B.; Mobashery, S.

Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli

Biochemistry

46

10113-10121

2007

Escherichia coli

17685588

brenda

683602

Leimanis, S.; Hoyez, N.; Hubert, S.; Laschet, M.; Sauvage, E.; Brasseur, R.; Coyette, J.

PBP5 complementation of a PBP3 deficiency in Enterococcus hirae

J. Bacteriol.

188

6298-6307

2006

Enterococcus faecium, Enterococcus hirae

16923897

brenda

683609

Priyadarshini, R.; de Pedro, M.A.; Young, K.D.

Role of peptidoglycan amidases in the development and morphology of the division septum in Escherichia coli

J. Bacteriol.

189

5334-5347

2007

Escherichia coli

17483214

brenda

683610

Varma, A.; de Pedro, M.A.; Young, K.D.

FtsZ directs a second mode of peptidoglycan synthesis in Escherichia coli

J. Bacteriol.

189

5692-5704

2007

Escherichia coli, Escherichia coli MG1655

17513471

brenda

683630

Cremniter, J.; Mainardi, J.; Josseaume, N.; Quincampoix, J.; Dubost, L.; Hugonnet, J.; Marie, A.; Gutmann, L.; Rice, L.B.; Arthur, M.

Novel mechanism of resistance to glycopeptide antibiotics in Enterococcus faecium

J. Biol. Chem.

281

32254-32262

2006

Enterococcus faecium

16943188

brenda

731142

Smith, J.D.; Kumarasiri, M.; Zhang, W.; Hesek, D.; Lee, M.; Toth, M.; Vakulenko, S.; Fisher, J.F.; Mobashery, S.; Chen, Y.

Structural analysis of the role of Pseudomonas aeruginosa penicillin-binding protein 5 in beta-lactam resistance

Antimicrob. Agents Chemother.

57

3137-3146

2013

Pseudomonas aeruginosa (G3XD74), Pseudomonas aeruginosa ATCC 15692 (G3XD74)

23629710

brenda

752508

Montealegre, M.C.; Roh, J.H.; Rae, M.; Davlieva, M.G.; Singh, K.V.; Shamoo, Y.; Murray, B.E.

Differential penicillin-binding protein 5 (PBP5) levels in the Enterococcus faecium clades with different levels of ampicillin resistance

Antimicrob. Agents Chemother.

61

e02034

2017

Enterococcus faecium (A0A075Q0W3)

27821450

brenda

753367

Maryam Pourhajibaghe, M.P.; Yazdi, M.; Bahador, A.

In silico analysis of penicillin-binding protein 5 as an inhibitory target of beta-lactam antibiotics in Enterococcus faecalis

Der Pharma Chem.

7

301-306

2015

Enterococcus faecalis (Q47800)

-

brenda

754019

Pandey, S.; Pal, S.; N, G.; Bansal, A.; Mallick, S.; Ghosh, A.

Two DD-carboxypeptidases from Mycobacterium smegmatis affect cell surface properties through regulation of peptidoglycan cross-linking and glycopeptidolipids

J. Bacteriol.

200

e00760

2018

Mycolicibacterium smegmatis (A0QV34), Mycolicibacterium smegmatis (A0QV35), Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084 (A0QV34), Mycolicibacterium smegmatis ATCC 700084 (A0QV35)

29735762

brenda

754639

Belhaj, M.; Boutiba-Ben Boubaker, I.; Slim, A.

Penicillin-binding protein 5 sequence alteration and levels of plp5 mRNA expression in clinical isolates of Enterococcus faecium with different levels of ampicillin resistance

Microb. Drug Resist.

22

202-210

2016

Enterococcus faecium (A0A075Q0W3)

26618475

brenda

Entries 1 - 20 of 27

Show complete table

html completed