3.4.17.8: muramoylpentapeptide carboxypeptidase

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For detailed information about muramoylpentapeptide carboxypeptidase, go to the full flat file.

Reaction

cleavage of the bond UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-6-carboxy-L-lysyl-D-alanyl-/-D-alanine =

Synonyms

carboxypeptidase D-alanyl-D-alanine, carboxypeptidase I, carboxypeptidase, muramoylpentapeptide, D-alanine carboxypeptidase, D-alanine carboxypeptidase I, D-alanine-D-alanine-carboxypeptidase, D-alanyl-D-alanine carboxypeptidase, D-alanyl-D-alanine peptidase, DacC, DD-Carboxypeptidase, DD-CPase, DD-peptidase, EC 3.4.12.6, Metallo DD-peptidase, msmeg_2432, msmeg_2433, PBP 5, PBP5, PdcA, penicillin binding protein 5, penicillin-binding protein 5, UDP-N-acetylmuramoyl-tetrapeptidyl-D-alanine alanine-hydrolase, VanX, VanXYc, VanY, Zn DD-peptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.17 Metallocarboxypeptidases

                3.4.17.8 muramoylpentapeptide carboxypeptidase

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Results	in table
1	Activating Compound
25	AA Sequence
2	Application
1	CAS Registry Number
5	Cloned(Commentary)
5	Crystallization (Commentary)
1	Expression
2	General Information
39	Inhibitors
2	kcat/KM [mM/s]
7	Ki Value [mM]
14	KM Value [mM]
12	Localization
12	Metals/Ions
3	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
72	Organism
1	PDB ID
6	pH Optimum
1	pH Range
1	pI Value
22	Protein Variants
3	Purification (Commentary)
3	Reaction
1	Reaction Type
34	Reference
13	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
53	Substrates and Products (Substrate)
1	Subunits
44	Synonyms
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
4	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.17.8 - muramoylpentapeptide carboxypeptidase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

modeling of structure

Enterococcus faecalis

Q47800

753367

crystal structure of recombinant protein, with deletion off the C-terminal anchor, at a 2.05 A resolution. Structure contains a shortened loop spanning residues 74 to 78 near the active site and two active-site residues, Ser101 and Lys203. An active-site flexibility may explain its carbapenemase activity

Pseudomonas aeruginosa

G3XD74

731142

-

2 entries

-

Streptomyces albus

-

28886, 36423

-

Streptomyces sp.

-

36311