3.4.17.4: Gly-Xaa carboxypeptidase
This is an abbreviated version!
For detailed information about Gly-Xaa carboxypeptidase, go to the full flat file.
Reaction
Release of a C-terminal amino acid from a peptide in which glycine is the penultimate amino acid, e.g. Z-Gly-/-Leu =
Synonyms
carboxypeptidase a, carboxypeptidase S, CPS1, Cps1p, EC 3.4.12.8, EC 3.4.17.9, EC 3.4.2.3, GLY-X carboxypeptidase, glycine carboxypeptidase, YSCS
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Inhibitors
Inhibitors on EC 3.4.17.4 - Gly-Xaa carboxypeptidase
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p-chloromercuribenzoate
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irreversible inhibition, no reactivation by addition of bivalent metal ions or SH-protecting reagents like cysteine and beta-mercaptomethanol
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0.1 mM and 1 mM, 95.6% and 74.7% compared to a control without additives
1,10-phenanthroline
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Ki: 0.035 mM, reversible by addtion of bivalent metal ions like Zn2+, Co2+, Cd2+ and Mn2+
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0.1 mM and 1 mM, 32.3% and 24.3% compared to a control without additives
EDTA
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Ki: 0.013 mM, reversible by addtion of bivalent metal ions like Zn2+, Co2+, Cd2+ and Mn2+, Zn2+ and Co2+, at a concentration of 0.1 mM, are most effecient with 88% and 62% reactivation
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0.1 mM and 1 mM, 110.5% and 94.8% compared to a control without additives
iodoacetate
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40% inhibition at a concentration of 5 mM, irreversible inhibition, no reactivation by addition of bivalent metal ions or SH-protecting reagents like cysteine and beta-mercaptomethanol