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3.4.17.23: angiotensin-converting enzyme 2

This is an abbreviated version!
For detailed information about angiotensin-converting enzyme 2, go to the full flat file.

Word Map on EC 3.4.17.23

Reaction

angiotensin II
+
H2O
=
angiotensin-(1-7)
 +
L-phenylalanine

Synonyms

ACE, ACE 2, ACE-2, ACE-related carboxypeptidase, ACE2, ACE2 homologue, ACEH, ACEII, Ang converting enzyme 2, angiotensin converting enzyme 2, angiotensin converting enzyme II, angiotensin converting enzyme-2, angiotensin II converting enzyme 2, angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin-converting enzyme homolog, angiotensin-converting enzyme homologue, angiotensin-converting enzyme type 2, angiotensin-converting enzyme-2, angiotensin-converting enzyme-like protein, angiotensin-converting enzyme-related carboxypeptidase, angiotensinase, hACE2, sACE2, soluble angiotensin converting enzyme 2, TMPRSS2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.17 Metallocarboxypeptidases
                3.4.17.23 angiotensin-converting enzyme 2

Subunits

Subunits on EC 3.4.17.23 - angiotensin-converting enzyme 2

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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
1 * 87000, mass photometry, purified ACE2 ectodomain
tetramer
a super-potent tetravalent form of ACE2 is produced by protein engineering technology, that couples to the human immunoglobulin gamma1 Fc region, using a self-assembling, tetramerization domain from p53 protein. This high molecular weight Quad protein (ACE2-Fc-TD) retains binding to the SARS-CoV-2 receptor binding spike protein and can form a complex with the spike protein plus anti-viral antibodies. The ACE2-Fc-TD acts as a powerful decoy protein that out-performs soluble monomeric and dimeric ACE2 proteins and blocks both SARS-CoV-2 pseudovirus and SARS-CoV-2 virus infection with greatly enhanced efficacy
additional information