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3.4.17.23: angiotensin-converting enzyme 2

This is an abbreviated version!
For detailed information about angiotensin-converting enzyme 2, go to the full flat file.

Word Map on EC 3.4.17.23

Reaction

angiotensin II
+
H2O
=
angiotensin-(1-7)
 +
L-phenylalanine

Synonyms

ACE, ACE 2, ACE-2, ACE-related carboxypeptidase, ACE2, ACE2 homologue, ACEH, ACEII, Ang converting enzyme 2, angiotensin converting enzyme 2, angiotensin converting enzyme II, angiotensin converting enzyme-2, angiotensin II converting enzyme 2, angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin-converting enzyme homolog, angiotensin-converting enzyme homologue, angiotensin-converting enzyme type 2, angiotensin-converting enzyme-2, angiotensin-converting enzyme-like protein, angiotensin-converting enzyme-related carboxypeptidase, angiotensinase, hACE2, sACE2, soluble angiotensin converting enzyme 2, TMPRSS2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.17 Metallocarboxypeptidases
                3.4.17.23 angiotensin-converting enzyme 2

Cloned

Cloned on EC 3.4.17.23 - angiotensin-converting enzyme 2

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
30 M HEK293 Freestyle cells are transfected with 293fectin combined with 30 mg of pFuse-based vectors containing the ACE2 construct
ACE2 expressed in Chinese hamster ovary cells specifically binds to glutathione-S-transferase-calmodulin, but not glutathione-S-transferase alone
ACE2 expression analysis
ACE2 expression analysis by RT-PCR
-
cloning and expression of a constitutively secreted form of ACE2, WKY rats are transduced with lentiviral vector containing shACE2. The plasma ACE2 levels could be increased by lentivector-mediated shACE2 gene transfer. This provides a tool to investigate the role of this enzyme in the development of the cardiovascular disease both through the role of hyperactivity of the RAS and through infectious agents
-
cloning of the enzyme utilizing the murine cytomegalovirus immediate early gene promoter, MCMV Pr, in an adenoviral vector for ACE2 overexpression in rats as a gene therapy model. overview
-
development of a transgenic mouse model (syn-hACE2) where the full open reading frame of the human ACE2 gene is under the control of a synapsin promoter, allowing the hACE2 protein to be expressed specifically in neurons
DNA and amino acid sequence determination, gene maps to choromosomal location Xp22, expression in CHO cells of the wild-type and of the soluble truncated mutant, the latter as c-Myc- and His-tagged protein
expressed in CHO cells
-
expressed in Escherichia coli BL21(DE3) cells
expressed in HEK 293-T cells
-
expressed in HEK-ACE2 cells
-
expressed in the endothelial cell line Eahy926
expression in CHO cells
-
expression in CHO cells and polarized Madin-Darby canine kidney epithelial cells
-
expression in E4 cells
-
expression in HEK-293 cells
expression in Spodoptera frugiperda Sf9 cells via infection with baculovirus
expression in the avian fibroblast cell line, DF1
expression of a fusion of ACE2 to the Fc domain of IgG1
expression of extracellular domain and wild-type, both as FLAG-tagged proteins, in Spodotera frugiperda Sf9 cells via baculovirus infection
expression of recombinant ACE2 in P-selectin-transfected Chinese hamster ovary cells
expression of the extracellular domain of human ACE2, residues Gln18-Ser740
expression of the mutant enzyme in CHO cells
expression of wild-type and utant L584A ACE2 in HEK-293 cells
gene ACE2, DNA sequence determination and analysis, expression in CHO K1 cells, secretion of the active enzyme from transfected cells by cleavage N-terminal to the transmembrane domain
N-terminal SNAP-tagged human ACE2 labeled with terbium, expression in EK-293 cell
overexpression of ACE2, by usage of a recombinant adeno-associated virus 6 delivery system, in myocardium of stroke-prone spontaneously hypertensive rats, gene expression profiling, overview
-
Sf21 cells via infection with baculovirus, mIgG-tagged protein