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3.4.17.21: Glutamate carboxypeptidase II

This is an abbreviated version!
For detailed information about Glutamate carboxypeptidase II, go to the full flat file.

Word Map on EC 3.4.17.21

Reaction

release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates =

Synonyms

100 kDa ileum brush border membrane protein, Acetylaspartylglutamate dipeptidase, altered meristem program1, AMP1, Dipeptidase, acetylaspartylglutamate, EC 3.4.19.8, FGCP, folate hydrolase, folate hydrolase 1, FOLH1, Folylpoly-gamma-glutamate carboxypeptidase, folylpoly-gamma-glutamate carboxypeptidase II, GCP II, GCPII, GCPIII, glutamate carboxypeptidase, glutamate carboxypeptidase II, glutamate carboxypeptidase III, GPCPII, I100, Ileal dipeptidylpeptidase, Membrane glutamate carboxypeptidase, mGCP, More, N-acetyl-alpha-linked acidic dipeptidase, N-acetyl-alpha-linked acidic dipeptidase I, N-acetylaspartylglutamate peptidase, N-acetylated alpha-linked acid dipeptidase, N-Acetylated alpha-linked acidic dipeptidase, N-Acetylated-alpha-linked acidic dipeptidase, N-acetylated-alpha-linked acidic dipeptidase 2, N-acetylated-alpha-linked acidic dipeptidase II, N-Acetylated-alpha-linked-acidic dipeptidase, N-acetylated-alpha-linked-acidic-dipeptidase, N-Acetylated-alpha-linked-amino dipeptidase, NAADLADase, NAADLADse, NAAG degradation enzyme, NAAG peptidase, NAAG peptidase II, NAAG-hydrolyzing activity, NAALA dipeptidase, NAALADase, Naaladase I, NAALADase II, NLD I, PMSA, prostate specific membrane antigen, Prostate-specific membrane antigen, Prostate-specific membrane antigen homolog, prostate-specificmembrane antigen, Prostrate-specific membrane antigen, PSM, PSM antigen, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase, Rat NAAG peptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.17 Metallocarboxypeptidases
                3.4.17.21 Glutamate carboxypeptidase II

Substrates Products

Substrates Products on EC 3.4.17.21 - Glutamate carboxypeptidase II

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
amyloid-beta + H2O
?
show the reaction diagram
the enzyme has two distinctive binding sites for two different substrates. Amyloid-beta degradation occurs through S1 pocket but not through S1' pocket responsible for hydrolysis of N-acetyl-L-aspartyl-L-glutamate. Pre-incubation with N-acetyl-L-aspartyl-L-glutamate and amyloid-beta does not affect amyloid-beta degradation and hydrolysis of N-acetyl-L-aspartyl-L-glutamate, respectively
-
-
?
folyl-(gamma-L-glutamic acid)2 + H2O
folyl-gamma-L-glutamic acid + L-glutamate
show the reaction diagram
-
-
-
?
folyl-(gamma-L-glutamic acid)3 + H2O
folyl-(gamma-L-glutamic acid)2 + L-glutamate
show the reaction diagram
-
-
-
?
folyl-(gamma-L-glutamic acid)4 + H2O
folyl-(gamma-L-glutamic acid)3 + L-glutamate
show the reaction diagram
-
-
-
?
folyl-gamma-L-glutamic acid + H2O
folate + L-glutamate
show the reaction diagram
-
-
-
?
folyl-poly-gamma-glutamate + H2O
?
show the reaction diagram
-
cleavage of the C-terminal glutamate
-
-
?
gamma-L-Glu-L-Glu + H2O
L-Glu + L-Glu
show the reaction diagram
-
-
-
-
?
L-Asp-L-Glu + H2O
L-Asp + L-Glu
show the reaction diagram
-
-
-
-
?
L-Glu-L-Glu + H2O
L-Glu + L-Glu
show the reaction diagram
-
-
-
-
?
methotrexate triglutamate + H2O
L-Glu + methotrexate
show the reaction diagram
-
-
-
?
N-acetyl-alpha L-aspartyl-L-glutamate + H2O
N-acetyl-L-aspartate + L-glutamate
show the reaction diagram
-
-
-
-
?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O
N-acetyl-alpha-L-aspartate + L-glutamate
show the reaction diagram
N-acetyl-Asp-Glu + H2O
N-acetyl-Asp + Glu
show the reaction diagram
N-Acetyl-L-Asp-L-Glu + H2O
?
show the reaction diagram
N-Acetyl-L-Asp-L-Glu + H2O
N-Acetyl-L-Asp + L-Glu
show the reaction diagram
N-acetyl-L-aspartyl-L-glutamate
N-acetyl-L-aspartate + L-glutamate
show the reaction diagram
-
-
-
?
N-acetyl-L-aspartyl-L-glutamate + H2O
L-glutamate + N-acetyl-L-aspartate
show the reaction diagram
N-acetyl-L-aspartyl-L-glutamate + H2O
N-acetyl-L-Asp + L-Glu
show the reaction diagram
N-acetyl-L-aspartyl-L-glutamate + H2O
N-acetyl-L-aspartate + L-glutamate
show the reaction diagram
N-[4-(phenylazo)-benzoyl]-L-glutamyl-gamma-L-glutamic acid + H2O
?
show the reaction diagram
-
-
-
-
?
poly-gamma-glutamate folate + H2O
?
show the reaction diagram
poly-gamma-Glutamylfolate + H2O
L-Glu + gamma-glutamylfolate
show the reaction diagram
-
-
removes sequentially gamma-linked glutamates
?
pteroyl-di-L-glutamate + H2O
L-Glu + pteroylglutamate
show the reaction diagram
pteroylpentaglutamate + H2O
L-Glu + pteroylglutamate
show the reaction diagram
-
-
-
?
additional information
?
-