3.4.17.21: Glutamate carboxypeptidase II

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For detailed information about Glutamate carboxypeptidase II, go to the full flat file.

Word Map on EC 3.4.17.21

3.4.17.21

tomography

positron

metastases

psma-targeted

node

lncap

tracer

prostatectomy

castration-resistant

modal

radioligands

androgen

psma-positive

radiotherapy

radionuclide

68ga-psma

biodistribution

radiotracers

neovasculature

radiopharmaceutical

mcrpc

theranostic

pelvic

gleason

psma-expressing

suvmax

restaging

oligometastatic

68ga-labeled

multiparametric

urea-based

spect

dosimetry

scintigraphy

abiraterone

castrate-resistant

n-acetylaspartate

extraprostatic

mpmri

pet-ct

enzalutamide

18f-labeled

positron-emission

tomography-computed

radium-223

pharmacology

radioimmunotherapy

medicine

tumor-to-background

analysis

radiometals

postprostatectomy

per-patient

diagnostics

drug development

Reaction

release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates =

Synonyms

100 kDa ileum brush border membrane protein, Acetylaspartylglutamate dipeptidase, altered meristem program1, AMP1, Dipeptidase, acetylaspartylglutamate, EC 3.4.19.8, FGCP, folate hydrolase, folate hydrolase 1, FOLH1, Folylpoly-gamma-glutamate carboxypeptidase, folylpoly-gamma-glutamate carboxypeptidase II, GCP II, GCPII, GCPIII, glutamate carboxypeptidase, glutamate carboxypeptidase II, glutamate carboxypeptidase III, GPCPII, I100, Ileal dipeptidylpeptidase, Membrane glutamate carboxypeptidase, mGCP, More, N-acetyl-alpha-linked acidic dipeptidase, N-acetyl-alpha-linked acidic dipeptidase I, N-acetylaspartylglutamate peptidase, N-acetylated alpha-linked acid dipeptidase, N-Acetylated alpha-linked acidic dipeptidase, N-Acetylated-alpha-linked acidic dipeptidase, N-acetylated-alpha-linked acidic dipeptidase 2, N-acetylated-alpha-linked acidic dipeptidase II, N-Acetylated-alpha-linked-acidic dipeptidase, N-acetylated-alpha-linked-acidic-dipeptidase, N-Acetylated-alpha-linked-amino dipeptidase, NAADLADase, NAADLADse, NAAG degradation enzyme, NAAG peptidase, NAAG peptidase II, NAAG-hydrolyzing activity, NAALA dipeptidase, NAALADase, Naaladase I, NAALADase II, NLD I, PMSA, prostate specific membrane antigen, Prostate-specific membrane antigen, Prostate-specific membrane antigen homolog, prostate-specificmembrane antigen, Prostrate-specific membrane antigen, PSM, PSM antigen, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase, Rat NAAG peptidase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.17 Metallocarboxypeptidases

3.4.17.21 Glutamate carboxypeptidase II

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Results	in table
1	Activating Compound
189	AA Sequence
40	Application
1	CAS Registry Number
25	Cloned(Commentary)
12	Crystallization (Commentary)
7461	Disease/ Diagnostics
5	Expression
9	General Information
3	General Stability
121	IC50 Value
374	Inhibitors
4	kcat/KM [mM/s]
108	Ki Value [mM]
15	KM Value [mM]
83	Localization
41	Metals/Ions
8	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
128	Organism
2	Pathway
90	PDB ID
15	pH Optimum
2	pH Range
17	Posttranslational Modification
37	Protein Variants
14	Purification (Commentary)
4	Reaction
7	Reaction Type
126	Reference
230	Source Tissue
10	Specific Activity [micromol/min/mg]
144	Substrates and Products (Substrate)
10	Subunits
261	Synonyms
14	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Turnover Number [1/s]

Purification

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Purification on EC 3.4.17.21 - Glutamate carboxypeptidase II

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4 entries

efficient one-step purification method yields purified recombinant enzyme

2 entries

FLAG affinity chromatography, full-length enzyme and mutant enzymes DELTA1-42 and DELTA20-42

Homo sapiens

656634

membrane fractions are prepared using mouse brain tissue samples

Mus musculus

701258

native enzyme from LNCaP cells by conformational epitope-specific antibody-affinity chromatography in presence of Zn2+ in a native and active conformation

Homo sapiens

670794

partially by membrane preparation

2 entries

purification consists of four steps, QAE-Sephadex A50 batch chromatography, chromatography on a Source 15S column, affinity chromatography using lentil lectin Sepharose, and gel filtration on a Superdex 200 column

Homo sapiens

Q04609

696330

recombinant enzyme from CHO cells partially by membrane preparation

Homo sapiens

656468

recombinant His6-tagged extracellular portion of the enzyme from High5 by nickel affinity chromatography and gel filtration

Homo sapiens

Q04609

670685