3.4.17.21: Glutamate carboxypeptidase II

This is an abbreviated version!
For detailed information about Glutamate carboxypeptidase II, go to the full flat file.

Reaction

release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates =

Synonyms

100 kDa ileum brush border membrane protein, Acetylaspartylglutamate dipeptidase, altered meristem program1, AMP1, Dipeptidase, acetylaspartylglutamate, EC 3.4.19.8, FGCP, folate hydrolase, folate hydrolase 1, FOLH1, Folylpoly-gamma-glutamate carboxypeptidase, folylpoly-gamma-glutamate carboxypeptidase II, GCP II, GCPII, GCPIII, glutamate carboxypeptidase, glutamate carboxypeptidase II, glutamate carboxypeptidase III, GPCPII, I100, Ileal dipeptidylpeptidase, Membrane glutamate carboxypeptidase, mGCP, More, N-acetyl-alpha-linked acidic dipeptidase, N-acetyl-alpha-linked acidic dipeptidase I, N-acetylaspartylglutamate peptidase, N-acetylated alpha-linked acid dipeptidase, N-Acetylated alpha-linked acidic dipeptidase, N-Acetylated-alpha-linked acidic dipeptidase, N-acetylated-alpha-linked acidic dipeptidase 2, N-acetylated-alpha-linked acidic dipeptidase II, N-Acetylated-alpha-linked-acidic dipeptidase, N-acetylated-alpha-linked-acidic-dipeptidase, N-Acetylated-alpha-linked-amino dipeptidase, NAADLADase, NAADLADse, NAAG degradation enzyme, NAAG peptidase, NAAG peptidase II, NAAG-hydrolyzing activity, NAALA dipeptidase, NAALADase, Naaladase I, NAALADase II, NLD I, PMSA, prostate specific membrane antigen, Prostate-specific membrane antigen, Prostate-specific membrane antigen homolog, prostate-specificmembrane antigen, Prostrate-specific membrane antigen, PSM, PSM antigen, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase, Rat NAAG peptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.17 Metallocarboxypeptidases

                3.4.17.21 Glutamate carboxypeptidase II

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Results	in table
1	Activating Compound
189	AA Sequence
40	Application
1	CAS Registry Number
25	Cloned(Commentary)
12	Crystallization (Commentary)
7461	Disease/ Diagnostics
5	Expression
9	General Information
3	General Stability
121	IC50 Value
374	Inhibitors
4	kcat/KM [mM/s]
108	Ki Value [mM]
15	KM Value [mM]
83	Localization
41	Metals/Ions
8	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
128	Organism
2	Pathway
90	PDB ID
15	pH Optimum
2	pH Range
17	Posttranslational Modification
37	Protein Variants
14	Purification (Commentary)
4	Reaction
7	Reaction Type
126	Reference
230	Source Tissue
10	Specific Activity [micromol/min/mg]
144	Substrates and Products (Substrate)
10	Subunits
261	Synonyms
14	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Turnover Number [1/s]

Expression

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Expression on EC 3.4.17.21 - Glutamate carboxypeptidase II

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

androgen ablation can up-regulate PSMA expression

Homo sapiens

-

710458

docetaxel down-regulates the expression of androgen receptor and prostate-specific antigen but not prostate-specific membrane antigen in prostate cancer cell lines

Homo sapiens

-

710458

inhibition of LNCaP cell growth by mono- and bispecific antisense oligonucleotides directed against bcl-2 and epidermal growth factor receptor, EGFR, inhibition of expression of non-targeted proteins prostate-specific membrane antigen only by bcl-2-monospecific oligos, overview

Homo sapiens

-

709808

Lentivirus-mediated RNAi inhibits PSMA mRNA and protein expression in LNCaP and DU-145 cells, PSMA RNAi induces the changes of cell cycle, overview

Homo sapiens

Q04609

709812

withdrawal of 3,4-methylenedioxypyrovalerone reduces expression of glutamate carboxypeptidase II in the prefrontal cortex

Rattus norvegicus

P70627

755361