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3.4.17.2: carboxypeptidase B

This is an abbreviated version!
For detailed information about carboxypeptidase B, go to the full flat file.

Word Map on EC 3.4.17.2

Reaction

preferential release of a C-terminal lysine or arginine amino acid =

Synonyms

47 kDa zymogen granule membrane associated protein, aCAP, B carboxypeptidase, basic carboxypeptidase, carboxypeptidase B, Carboxypeptidase B1, carboxypeptidase B2, carboxypeptidase BII, Cbp, CPB, CPB1, CPB2, CPBAg1, cpbAs1, EC 3.4.12.3, EC 3.4.2.2, HBCPB, HzCPB, More, Pancreas-specific protein, PASP, PCB, PcpB, pp-CpB, ppCPB, protaminase, TAFI, thrombin-activatable fibrinolysis inhibitor, thrombin-activatable procarboxypeptidase B, tissue carboxypeptidase B, ZAP47

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.17 Metallocarboxypeptidases
                3.4.17.2 carboxypeptidase B

Turnover Number

Turnover Number on EC 3.4.17.2 - carboxypeptidase B

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3.67 - 427
benzoyl-Gly-Arg
0.333 - 5.5
benzoyl-Gly-Gly-Phe
2.83 - 917
benzoyl-Gly-glycylphenyllactic acid
86
benzoyl-Gly-L-Arg
-
-
1.9
biotin-(epsilon-aminocaproic acid)2-GLMVGGVVR
-
pH 7.4
2.5
carbobenbenzoxy-Gly-Phe
-
crystallized enzyme
104
Carbobenzoxy-Gly-Phe
-
soluble enzyme
50
furylacryloyl-L-alanyl-L-arginine
-
-
-
38.6
furylacryloyl-L-alanyl-L-lysine
-
-
-
58.7
furylacryloylalanylarginine
-
-
24.6
furylacryloylalanyllysine
-
-
61 - 119
hippuryl-Arg
0.16 - 0.26
hippuryl-Asp
3.8
hippuryl-Glu
-
mutant enzyme D253K
27.4 - 171
hippuryl-L-Arg
10.5 - 25.5
hippuryl-Lys
0.667
N-(phenylcarbonyl)glycyl-L-arginine
-
crystallized enzyme
53 - 57
N-benzoylglycyl-L-Arg
additional information
additional information
-
-
-