3.4.17.2: carboxypeptidase B
This is an abbreviated version!
For detailed information about carboxypeptidase B, go to the full flat file.
Word Map on EC 3.4.17.2
-
3.4.17.2
-
cardiopulmonary
-
cardiac
-
artery
-
postoperative
-
coronary
-
aortic
-
perioperative
-
myocardial
-
pulmonary
-
ventricular
-
hemodynamic
-
heparin
-
transfusion
-
elective
-
circuit
-
intraoperative
-
valve
-
bleeding
-
hypothermic
-
anesthesia
-
venous
-
extracorporeal
-
ventilation
-
protamine
-
inotropic
-
cardioplegia
-
sternotomy
-
rewarming
-
hemodilution
-
revascularization
-
cross-clamping
-
atrial
-
normothermic
-
wean
-
hematocrit
-
circulatory
-
off-pump
-
analysis
-
cardiothoracic
-
synthesis
-
intra-aortic
-
medicine
-
open-heart
-
thoracotomy
-
in-hospital
-
drug development
-
extubation
-
pharmacology
-
crystalloid
-
cannulation
-
roller
-
transesophageal
-
fentanyl
-
antegrade
-
reoperation
-
diagnostics
- 3.4.17.2
-
cardiopulmonary
- cardiac
- artery
-
postoperative
- coronary
- aortic
-
perioperative
- myocardial
- pulmonary
- ventricular
-
hemodynamic
- heparin
-
transfusion
-
elective
-
circuit
-
intraoperative
- valve
-
bleeding
-
hypothermic
-
anesthesia
- venous
-
extracorporeal
-
ventilation
- protamine
-
inotropic
-
cardioplegia
-
sternotomy
-
rewarming
-
hemodilution
-
revascularization
-
cross-clamping
- atrial
-
normothermic
-
wean
-
hematocrit
-
circulatory
-
off-pump
- analysis
-
cardiothoracic
- synthesis
-
intra-aortic
- medicine
-
open-heart
-
thoracotomy
-
in-hospital
- drug development
-
extubation
- pharmacology
- crystalloid
-
cannulation
-
roller
-
transesophageal
-
fentanyl
-
antegrade
-
reoperation
- diagnostics
Reaction
preferential release of a C-terminal lysine or arginine amino acid =
Synonyms
47 kDa zymogen granule membrane associated protein, aCAP, B carboxypeptidase, basic carboxypeptidase, carboxypeptidase B, Carboxypeptidase B1, carboxypeptidase B2, carboxypeptidase BII, Cbp, CPB, CPB1, CPB2, CPBAg1, cpbAs1, EC 3.4.12.3, EC 3.4.2.2, HBCPB, HzCPB, More, Pancreas-specific protein, PASP, PCB, PcpB, pp-CpB, ppCPB, protaminase, TAFI, thrombin-activatable fibrinolysis inhibitor, thrombin-activatable procarboxypeptidase B, tissue carboxypeptidase B, ZAP47
ECTree
3.4.17.2 carboxypeptidase BAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 3.4.17.2 - carboxypeptidase B
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(2R)-2-(3-carbamimidamidophenyl)-3-sulfanylpropanoic acid
binding structure analysis
(2S)-7-amino-2-[(hydroxy[(1R)-2-methyl-1-[(3-phenylpropanoyl)amino]propyl]phosphoryl)methyl]heptanoic acid
-
(S)-2-(2-((S)-1-carboxy-2-(1H-imidazol-5-yl)ethylamino)ethylamino)-5-guanidinopentanoic acid
IC50: 17 microgram/ml
2-(4-(furan-2-ylmethyl)-5-(4-hydroxyphenyl)-4H-1,2,4-triazol-3-ylthio)-1-(thiophen-2-yl)ethanone
-
2-(5-carbamimidamido-2-chlorophenyl)-3-sulfanylpropanoic acid
binding structure analysis
2-(6,9-dimethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(4-fluorophenyl)ethanone
-
-
4-(5-(2-chlorobenzylthio)-1,3,4-oxadiazol-2-yl)-N-(thiophen-2-ylmethyl)benzensulfonamide
-
-
5-carbamimidamido-2-(sulfanylmethyl)pentanoic acid
binding structure analysis
lipopolysaccharide
-
lipopolysaccharide treatment significantly decreases carboxypeptidase B activity. Administration of 5,5-dimethyl-1-pyrroline N-oxide to LPS-treated mice alleviates this loss of enzyme activity
methyl (1R,2S)-2-([[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)cyclobutanecarboxylate
-
-
methyl (1S,2R)-2-([[(1S,2R)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)cyclobutanecarboxylate
-
-
methyl 5-([[(1S,2R)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]amino)pentanoate
-
-
methyl N-[[(1R,2S)-2-([N-[(benzyloxy)carbonyl]-beta-alanyl]amino)cyclobutyl]carbonyl]-beta-alaninate
-
-
methyl N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]-beta-alaninate
-
-
methyl N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]glycinate
-
-
N-(3-chlorophenyl)-4-((5-((3-methoxybenzyl)thio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine
N-(3-chlorophenyl)-4-((5-(3-methoxybenzylthio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine
-
N-[[(1R,2S)-2-[[(benzyloxy)carbonyl]amino]cyclobutyl]carbonyl]-beta-alaninate
-
-
N-[[di(propan-2-yl)amino]-[3-(4-methoxyphenyl)-2-trimethylsilyloxiran-2-yl]phosphinothioyl]-N-propan-2-ylpropan-2-amine
-
1-(4-chlorophenyl)-2-(5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-ylthio)ethanone
-
-
DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid
binding structure analysis
isopropyl 2-(4-benzyl-5-(2-methoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate
-
-
N-(3-chlorophenyl)-4-((5-((3-methoxybenzyl)thio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine
-
-
N-(3-chlorophenyl)-4-((5-((3-methoxybenzyl)thio)-1,3,4-oxadiazol-2-yl)methyl)thiazol-2-amine
-
-
tick carboxypeptidase inhibitor
-
TCI, from the ixodid tick Rhipicephalus bursa, recombinant expression in Escherichia coli, DNA and amino acid sequence determination and analysis, binding structure and inhibition mechanism, overview
-
tick carboxypeptidase inhibitor
TCI, from Rhipicephalus bursa, recombinantly expressd in Escherichia coli strain BL21(DE3) periplasm and purification by cation exchange and adsorption chromatography, binding structure at the active site, overview
-
additional information
-
the enzyme is down-regulates upon feeding, the enzyme expression in the midgut is affected by ingestion of Plasmodium falciparum
-
additional information
no or poor inhibition of the enzyme by potato carboxypeptidase inhibitor, dependent on the pH, in contrast to other carboxypeptidases in the gut
-
additional information
-
no or poor inhibition of the enzyme by potato carboxypeptidase inhibitor, dependent on the pH, in contrast to other carboxypeptidases in the gut
-
