3.4.17.17: tubulinyl-Tyr carboxypeptidase

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For detailed information about tubulinyl-Tyr carboxypeptidase, go to the full flat file.

Reaction

Cleavage of the -Glu!Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr =

Synonyms

AGBL4, brain I carboxypeptidase, carboxypeptidase, tubulin-tyrosine, carboxypeptidase-tubulin, MAP1B, microtubule-associated protein 1B, nervous system nuclear protein induced by axotomy, Nna1-like peptidase, soluble carboxypeptidase, TCP, TTCPase, tubulin carboxypeptidase, tubulin tyrosine carboxypeptidase, tubulin-tyrosine carboxypeptidase, tubulinyltyrosine carboxypeptidase, tyrosinotubulin carboxypeptidase, tyrosyltubulin carboxypeptidase, vasohibin/SVBP complex

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.17 Metallocarboxypeptidases

                3.4.17.17 tubulinyl-Tyr carboxypeptidase

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Results	in table
6	Activating Compound
7	AA Sequence
4	Application
1	CAS Registry Number
3	Cloned(Commentary)
198	Disease/ Diagnostics
1	General Information
2	General Stability
28	Inhibitors
3	Localization
2	Metals/Ions
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
16	Organism
32	PDB ID
1	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
16	Reference
16	Source Tissue
16	Substrates and Products (Substrate)
22	Synonyms

Natural Substrates Products

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Natural Substrates Products on EC 3.4.17.17 - tubulinyl-Tyr carboxypeptidase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

alpha-tubulin + H2O

detyrosinated tubulin + Tyr

Cricetulus griseus

-

the enzyme could be part of the mechanism that regulates the tyrosination state of microtubules

647266

-

-

?