3.4.17.17: tubulinyl-Tyr carboxypeptidase
This is an abbreviated version!
For detailed information about tubulinyl-Tyr carboxypeptidase, go to the full flat file.
Word Map on EC 3.4.17.17
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3.4.17.17
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neurite
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cytoskeletal
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map2
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dendrite
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tau
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outgrowth
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synaptic
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cone
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hippocampal
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detyrosinated
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neurofilament
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alpha-tubulin
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neuritogenesis
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microtubule-binding
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proline-directed
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microtubule-stabilizing
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somatodendritic
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nf-m
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parthenolide
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medicine
- 3.4.17.17
-
neurite
- cytoskeletal
- map2
- dendrite
- tau
-
outgrowth
- synaptic
- cone
- hippocampal
-
detyrosinated
- neurofilament
- alpha-tubulin
-
neuritogenesis
-
microtubule-binding
-
proline-directed
-
microtubule-stabilizing
-
somatodendritic
- nf-m
- parthenolide
- medicine
Reaction
Cleavage of the -Glu!Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr =
Synonyms
AGBL4, brain I carboxypeptidase, carboxypeptidase, tubulin-tyrosine, carboxypeptidase-tubulin, MAP1B, microtubule-associated protein 1B, nervous system nuclear protein induced by axotomy, Nna1-like peptidase, soluble carboxypeptidase, TCP, TTCPase, tubulin carboxypeptidase, tubulin tyrosine carboxypeptidase, tubulin-tyrosine carboxypeptidase, tubulinyltyrosine carboxypeptidase, tyrosinotubulin carboxypeptidase, tyrosyltubulin carboxypeptidase, vasohibin/SVBP complex
ECTree
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Inhibitors
Inhibitors on EC 3.4.17.17 - tubulinyl-Tyr carboxypeptidase
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parthenolide
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efficiently inhibits. Inhibition of TCP activity is independent of NF-kappaB inhibition; inhibition of tubulin carboxypeptidase could be one of the mechanisms underlying the anticancer properties of parthenolide
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not inhibited by peptides and proteins with COOH-terminal tyrosine
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additional information
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dihydroparthenolide, costunolide and sulindac have no effect on TCP activity. Compounds from Vernonia perrottetii show potent TCP inhibitory activity
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additional information
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neurons lacking MAP1B, when exposed to drugs that reversibly depolymerize microtubules, do not fully recover tyrosinated microtubules upon drug removal. The microtubule-depolymerizing drug nocodazole does not affect MAP1B-TTL interaction. GST-TTL is able to pull down MAP1B, whereas GST itself does not
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