3.4.17.14: Zinc D-Ala-D-Ala carboxypeptidase

This is an abbreviated version!
For detailed information about Zinc D-Ala-D-Ala carboxypeptidase, go to the full flat file.

Reaction

cleavage of the bond: (Ac)2-L-lysyl-D-alanyl-/-D-alanine =

Synonyms

D-alanyl-D-alanine carboxypeptidase, D-Alanyl-D-alanine hydrolase, D-Alanyl-D-alanine-cleaving carboxypeptidase, DAP, DD-Carboxypeptidase, DD-Carboxypeptidase-transpeptidase, G enzyme, KM endopeptidase, More, PBP4, PBP4a, PBP4B, penicillin binding protein 4, penicillin-binding protein 4a, zinc D-Ala-D-Ala carboxypeptidase, Zn2+ G peptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.17 Metallocarboxypeptidases

                3.4.17.14 Zinc D-Ala-D-Ala carboxypeptidase

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Results	in table
299	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
2	Crystallization (Commentary)
5	Inhibitors
2	Ki Value [mM]
5	Localization
8	Metals/Ions
4	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
9	Organism
2	Pathway
1	pH Optimum
1	pI Value
2	Protein Variants
3	Purification (Commentary)
1	Reaction
2	Reaction Type
9	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
13	Substrates and Products (Substrate)
3	Subunits
18	Synonyms
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 3.4.17.14 - Zinc D-Ala-D-Ala carboxypeptidase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

Acetyl2-L-Lys-D-Ala-D-Ala + H2O

Acetyl2-L-Lys-D-Ala + D-Ala

3 entries

Nalpha,Nepsilon-diacetyl-Lys-D-Ala-D-Ala + H2O

Nalpha,Nepsilon-diacetyl-Lys-D-Ala + D-Ala

Escherichia coli

-

-

683097

-

-

?

Nalpha-Acetyl-L-Lys-D-Ala-D-Ala + H2O

Nalpha-Acetyl-L-Lys-D-Ala + D-Ala

2 entries

peptidoglycan + H2O

?

Streptomyces albus G

-

hydrolyzes peptidoglycan interpeptide bonds between a D-alanine and another D-amino acid residue in alpha-position to a free carboxylate

668822

-

-

?

additional information

?

-

6 entries

Acetyl2-L-Lys-D-Ala-D-Ala + H2O

Acetyl2-L-Lys-D-Ala + D-Ala

Streptomyces albus

-

-

28885

-

28885

?

Acetyl2-L-Lys-D-Ala-D-Ala + H2O

Acetyl2-L-Lys-D-Ala + D-Ala

Streptomyces sp.

-

-

28888

-

28888

?

Acetyl2-L-Lys-D-Ala-D-Ala + H2O

Acetyl2-L-Lys-D-Ala + D-Ala

Streptomyces sp. R39

-

-

28888

-

28888

?

Nalpha-Acetyl-L-Lys-D-Ala-D-Ala + H2O

Nalpha-Acetyl-L-Lys-D-Ala + D-Ala

Streptomyces sp.

-

-

28888

-

28888

?

Nalpha-Acetyl-L-Lys-D-Ala-D-Ala + H2O

Nalpha-Acetyl-L-Lys-D-Ala + D-Ala

Streptomyces sp. R39

-

-

28888

-

28888

?

additional information

?

-

Brucella abortus

-

DAP contributes to resistance against NO required for the intracellular growth of the bacterium

668670

-

-

?

additional information

?

-

Escherichia coli

-

the DD-carboxypeptidase activity encoded by pbp4B is not essential for the cell growth of Escherichia coli

683097

-

-

?

additional information

?

-

Escherichia coli

-

PBP4B shows penicillin-binding capacity and a low DD-carboxypeptidase activity

683097

-

-

?

additional information

?

-

Streptomyces albus

-

mechanism

28886

-

-

?

additional information

?

-

Streptomyces albus

-

weak beta-lactamase activity hydrolyzing penicillin into penicilloate

28885

-

-

?

additional information

?

-

Streptomyces albus

-

involved in bacterial cell wall metabolism

28886

-

-

?