3.4.17.12: carboxypeptidase M
This is an abbreviated version!
For detailed information about carboxypeptidase M, go to the full flat file.
Word Map on EC 3.4.17.12
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3.4.17.12
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pain
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women
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lymphocyte
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contralateral
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children
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postoperative
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prophylactic
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myelinolysis
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mastectomy
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pontine
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knee
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cyclophosphamide
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unilateral
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wave
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rehabilitation
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hyponatremia
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decision
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summation
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session
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flexion
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accelerometer
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myoelectrical
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chlorpheniramine
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preoperative
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arthroplasty
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noxious
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phytohemagglutinin
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3h-thymidine
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maleate
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pressor
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pain-free
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decision-making
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analgesia
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psychophysical
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actigraph
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pokeweed
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moderate-to-vigorous
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3h-tdr
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disomy
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myotomy
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cuff
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physiotherapy
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arthroscopic
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gastroparesis
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suprathreshold
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dysrhythmias
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breast-conserving
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medicine
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trapezius
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manometry
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resting-state
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diagnostics
- 3.4.17.12
- pain
- women
- lymphocyte
-
contralateral
- children
-
postoperative
-
prophylactic
- myelinolysis
-
mastectomy
- pontine
- knee
- cyclophosphamide
-
unilateral
-
wave
-
rehabilitation
- hyponatremia
-
decision
-
summation
-
session
-
flexion
-
accelerometer
-
myoelectrical
-
chlorpheniramine
-
preoperative
-
arthroplasty
-
noxious
- phytohemagglutinin
-
3h-thymidine
- maleate
-
pressor
-
pain-free
-
decision-making
-
analgesia
-
psychophysical
-
actigraph
-
pokeweed
-
moderate-to-vigorous
-
3h-tdr
-
disomy
-
myotomy
-
cuff
-
physiotherapy
-
arthroscopic
-
gastroparesis
-
suprathreshold
- dysrhythmias
-
breast-conserving
- medicine
-
trapezius
-
manometry
-
resting-state
- diagnostics
Reaction
cleavage of C-terminal arginine or lysine residues from polypeptides =
Synonyms
carboxypeptidase M, carboxypeptidase-M, CPM, M14006 (Merops-ID), More
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 3.4.17.12 - carboxypeptidase M
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REACTION DIAGRAM
Ala-Ser-His-Leu-Gly-Leu-Ala-Arg + H2O
Ala-Ser-His-Leu-Gly-Leu-Ala + Arg
human anaphylatoxin C3A fragment 70-77
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-
?
dynorphin A(1-13) + H2O
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu + Lys
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i.e. Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys
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-
?
epidermal growth factor + H2O
dea-Arg53-epidermal growth factor + arginine
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-
-
-
?
Gly-Leu-Ala-Arg + H2O
Gly-Leu-Ala + Arg
human anaphylatoxin C3A fragment 74-77
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-
?
His-Leu-Gly-Leu-Ala-Arg + H2O
His-Leu-Gly-Leu-Ala + Arg
human anaphylatoxin C3A fragment 72-77
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-
?
Leu-Ala-Arg + H2O
Leu-Ala + Arg
human anaphylatoxin C3A fragment 75-77
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-
?
Leu-Gly-Leu-Ala-Arg + H2O
Leu-Gly-Leu-Ala + Arg
human anaphylatoxin C3A fragment 73-77
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-
?
Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine
N-(4-hydroxybenzoyl)-Gly-Arg + H2O
N-(4-hydroxybenzoyl)-Gly + L-arginine
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-
-
?
SDF-1alpha + H2O
des-lys SDF-1alpha + lysine
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stromal cell-derived factor
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-
?
Ser-His-Leu-Gly-Leu-Ala-Arg + H2O
Ser-His-Leu-Gly-Leu-Ala + Arg
human anaphylatoxin C3A fragment 71-77
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-
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine
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bradykinin
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-
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine
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bradykinin
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-
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine
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bradykinin
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-
?
Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine
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kallidin
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-
?
Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + arginine
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kallidin
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-
?
?
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the enzyme may be responsible for control of kinins and epidermal growth factor as well as of EGF-like peptides
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-
?
additional information
?
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carboxypeptidase M does not hydrolyze the peptidyl dipeptidase substrate furylacryloyl-Phe-Gly-Gly or the carboxypeptidase A substrates benzoyl-Gly-phenyllactic acid and furylacryloyl-Phe-Phe
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?
additional information
?
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the enzyme could inactivate or modulate the activity of peptide hormones either before or after their interaction with plasma membrane receptors
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?
additional information
?
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the enzyme controls the activity of kinins in the kidney, is involved in inflammation, and participates in the metabolism of growth factors that contain C-terminal Arg or Lys residues, e.g. the epidermal growth factor, the nerve growth factor, the hypatocyte growth factor, the macrophage-stimulating protein, or erythropoietin
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-
?
additional information
?
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the enzyme might be involved in regulating the biological effects of complement anaphylatoxins at sites of tissue injury
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-
?
additional information
?
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the enzyme regulates peptide hormones and growth factors at the cell surface, and is active in the degradation of extracellular proteins in the membrane
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-
?
additional information
?
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the enzyme regulates peptide hormones and growth factors at the cell surface, and is active in the degradation of extracellular proteins in the membrane
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?
additional information
?
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removing of the C-terminal Arg residue of the intact kinins and related peptides
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-
?
additional information
?
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using small substrates of the form benzoyl-Xaa-Arg CPM has the highest catalytic efficiency for substrates with the nonpolar aliphatic residues Ala and Met and aromatic amino acids (Phe, Tyr, Trp) in the penultimate place and the lowest with branched side chains (Ile)
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-
?
additional information
?
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-
using small substrates of the form benzoyl-Xaa-Arg CPM has the highest catalytic efficiency for substrates with the nonpolar aliphatic residues Ala and Met and aromatic amino acids (Phe, Tyr, Trp) in the penultimate place and the lowest with branched side chains (Ile)
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-
?